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The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience

Autor: Jaishree Tripathi, Michal Stoklasa, Sourav Nayak, Kay En Low, Erica Qian Hui Lee, Quang Huy Duong Tien, Laurent Rénia, Benoit Malleret, Zbynek Bozdech

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Recrudescent infections with the human malaria parasite, Plasmodium falciparum, presented traditionally the major setback of artemisinin-based monotherapies. Although the introduction of artemisinin combination therapies (ACT) largely solved

Externí odkaz: https://doaj.org/article/4ffcc484e4134207a43f02335b616f7b

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CD24 induced cellular quiescence-like state and chemoresistance in ovarian cancer cells via miR-130a/301a-dependent CDK19 downregulation

Autor: Yeonsue Jang, Suki Kang, Hyun Ho Han, Baek Gil Kim, Nam Hoon Cho

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)

Abstract Cancer stem-like cell (CSC) is thought to be responsible for ovarian cancer recurrence. CD24 serves as a CSC marker for ovarian cancer and regulates the expression of miRNAs, which are regulators of CSC phenotypes. Therefore, CD24-regulated

Externí odkaz: https://doaj.org/article/dc28a4e90eb04ca1b82caeed691beccc

Author Correction: The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular quiescence/senescence and drug resilience.

Autor: Tripathi J; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore. jtmic@nus.edu.sg.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore. jtmic@nus.edu.sg., Stoklasa M; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., Nayak S; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., En Low K; Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Qian Hui Lee E; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Duong Tien QH; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore., Rénia L; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 636921, Singapore.; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Malleret B; Electron Microscopy Unit, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore.; Department of Microbiology and Immunology, Immunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore., Bozdech Z; School of Biological Sciences, Nanyang Technological University (NTU), Singapore, 637551, Singapore. zbozdech@ntu.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 30; Vol. 15 (1), pp. 8460. Date of Electronic Publication: 2024 Sep 30.