Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Cellular Protein Chemistry"'
Autor:
Hillenaar, Tamara, Beekman, Jeffrey, van der Sluijs, Peter, Braakman, Ineke, Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15170
International Journal of Molecular Sciences, 23(23). MDPI AG
International Journal of Molecular Sciences, 23(23). MDPI AG
Mutations in CFTR cause misfolding and decreased or absent ion-channel function, resulting in the disease Cystic Fibrosis. Fortunately, a triple-modulator combination therapy (Trikafta) has been FDA approved for 178 mutations, including all patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eafa0ff3a7018cd35886ddb0ce0638
https://dspace.library.uu.nl/handle/1874/426183
https://dspace.library.uu.nl/handle/1874/426183
Autor:
Koopman, Margreet B., Ferrari, Luca, Rüdiger, Stefan G.D., Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Trends in Neurosciences, 45(4), 257. Elsevier Limited
Protein aggregates are hallmarks of neurodegenerative diseases. The protein quality control (PQC) system normally prevents proteins from misfolding and accumulation; however, proteins somehow escape this control on disease. Here we review advances in
Autor:
McCaul, Nicholas, Quandte, Matthias, Bontjer, Ilja, van Zadelhoff, Guus, Land, Aafke, Crooks, Ema T., Binley, James M., Sanders, Rogier W., Braakman, Ineke, Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Cell Reports
Cell Reports, 36(9), 1. Elsevier Saunders
Cell reports, 36(9):109646. Cell Press
Cell Reports, 36(9), 1. Elsevier Saunders
Cell reports, 36(9):109646. Cell Press
SummaryRemoval of the membrane-tethering signal peptides that target secretory proteins to the endoplasmic reticulum is a prerequisite for proper folding. While generally thought to be removed well before translation termination, we here report two n
Autor:
Schildknegt, Danny, Lodder, Naomi, Pandey, Abhinav, Egmond, Maarten, Pena, Florentina, Braakman, Ineke, van der Sluijs, Peter, Sub Cellular Protein Chemistry, Sub Membrane Biochemistry & Biophysics, Cellular Protein Chemistry, Membrane Biochemistry and Biophysics
Publikováno v:
Protein Science, 28(7), 1276. Cold Spring Harbor Laboratory Press
Protein Science : A Publication of the Protein Society
Protein Science : A Publication of the Protein Society
The Canopy (CNPY) family consists of four members predicted to be soluble proteins localized to the endoplasmic reticulum (ER). They are involved in a wide array of processes, including angiogenesis, cell adhesion, and host defense. CNPYs are thought
Alzheimer Cells on Their Way to Derailment Show Selective Changes in Protein Quality Control Network
Autor:
Koopman, Margreet B., Rüdiger, Stefan G.D., Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, 7, 1. Frontiers Media S.A.
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences, 7, 1. Frontiers Media S.A.
Frontiers in Molecular Biosciences, Vol 7 (2020)
Alzheimer’s Disease is driven by protein aggregation and is characterised by accumulation of Tau protein into neurofibrillary tangles. In healthy neurons the cellular protein quality control is successfully in charge of protein folding, which raise
Autor:
Molenkamp, Jelle, den Outer, Anna, van Schijndel, Vera, Sinnige, Tessa, Sub Cellular Protein Chemistry, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Cellular Protein Chemistry
Publikováno v:
Journal of visualized experiments : JoVE, 178, 1. MYJoVE Corporation
Protein aggregation into insoluble inclusions is a hallmark of a variety of human diseases, many of which are age-related. The nematode Caenorhabditis elegans is a well-established model organism that has been widely used in the field to study protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb87cb4b94bf79158a46e1aff847908f
https://dspace.library.uu.nl/handle/1874/419327
https://dspace.library.uu.nl/handle/1874/419327
Autor:
Kleizen, Bertrand, Hunt, John F., Callebaut, Isabelle, Hwang, Tzyh Chang, Sermet-Gaudelus, Isabelle, Hafkemeyer, Sylvia, Sheppard, David N., Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Kleizen, B, Hunt, J, Callebaut, I, Hwang, T-C, Sermet-Gaudelus, I, Hafkemeyer, S & Sheppard, D N 2020, ' CFTR : New insights into structure and function and implications for modulation by small molecules ', Journal of Cystic Fibrosis, vol. 19, no. Supplement 1, pp. S19-S24 . https://doi.org/10.1016/j.jcf.2019.10.021
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, 2020, 19 (S1), pp.S19-S24. ⟨10.1016/j.jcf.2019.10.021⟩
Journal of Cystic Fibrosis, Elsevier, 2020, 19 (S1), pp.S19-S24. ⟨10.1016/j.jcf.2019.10.021⟩
Journal of Cystic Fibrosis, 19(suppl. 1), s19. Elsevier bedrijfsinformatie b.v.
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis, 2020, 19 (S1), pp.S19-S24. ⟨10.1016/j.jcf.2019.10.021⟩
Journal of Cystic Fibrosis, Elsevier, 2020, 19 (S1), pp.S19-S24. ⟨10.1016/j.jcf.2019.10.021⟩
Journal of Cystic Fibrosis, 19(suppl. 1), s19. Elsevier bedrijfsinformatie b.v.
International audience; Structural biology and functional studies are a powerful combination to elucidate fundamental knowledge about the cystic fibrosis transmembrane conductance regulator (CFTR). Here, we discuss the latest findings, including how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116512453739f03c45a8cf7ed7562216
https://research-information.bris.ac.uk/en/publications/28d184f5-f7d2-4cb8-adaf-150fabe8d048
https://research-information.bris.ac.uk/en/publications/28d184f5-f7d2-4cb8-adaf-150fabe8d048
Autor:
Ferrari, Luca, Stucchi, Riccardo, Konstantoulea, Katerina, van de Kamp, Gerarda, Kos, Renate, Geerts, Willie J C, van Bezouwen, Laura S, Förster, Friedrich G, Altelaar, Maarten, Hoogenraad, Casper C, Rüdiger, Stefan G D, Cryo-EM, Cellular Protein Chemistry, Biomolecular Mass Spectrometry and Proteomics, Celbiologie, Sub Cellular Protein Chemistry, Sub Cell Biology, Sub Cryo - EM, Afd Biomol.Mass Spect. and Proteomics
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications, 11(1):571. Nature Publishing Group
Nature Communications, 11(1), 1. Nature Publishing Group
Nature Communications
Nature communications, 11(1):571. Nature Publishing Group
Nature Communications, 11(1), 1. Nature Publishing Group
Aggregation of the Tau protein into fibrils defines progression of neurodegenerative diseases, including Alzheimer’s Disease. The molecular basis for potentially toxic reactions of Tau aggregates is poorly understood. Here we show that π-stacking
Autor:
Oliver, Kathryn E, Rauscher, Robert, Mijnders, Marjolein, Wang, Wei, Wolpert, Matthew J, Maya, Jessica, Sabusap, Carleen M, Kesterson, Robert A, Kirk, Kevin L, Rab, Andras, Braakman, Ineke, Hong, Jeong S, Hartman, John L, Ignatova, Zoya, Sorscher, Eric J, Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Journal of Clinical Investigation, 129(12), 5236. The American Society for Clinical Investigation
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), with approximately 90% of patients harboring at least one copy of the disease-associated variant F508del. We utilized a yeast phenomic system to identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8df353f61ddb2aceb14c2505c1c858
https://dspace.library.uu.nl/handle/1874/387704
https://dspace.library.uu.nl/handle/1874/387704
Autor:
Jarosińska, Olga D, Rüdiger, Stefan G D, Sub Developmental Biology, Sub Cellular Protein Chemistry, Cellular Protein Chemistry
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, 8, 1. Frontiers Media S.A.
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, 8, 1. Frontiers Media S.A.
Huntington’s disease (HD) is a neurodegenerative disorder caused by the aggregation of the mutant huntingtin (mHTT) protein in nerve cells. mHTT self-aggregates to form soluble oligomers and insoluble fibrils, which interfere in a number of key cel