Zobrazeno 1 - 10
of 891
pro vyhledávání: '"Cellular Physiology"'
Autor:
Florian Siegerist, Felix Kliewe, Elke Hammer, Paul Schakau, Joanne Ern Chi Soh, Claudia Weber, Maja Lindenmeyer, Simone Reichelt-Wurm, Vedran Drenic, Christos Chatziantoniou, Christos E. Chadjichristos, Yiying Zhang, Stefan Simm, Miriam C. Banas, Matthias Nauck, Uwe Völker, Nicole Endlich
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111329- (2024)
Summary: The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized. The role of ILDR2 in podocytes, specialized epithel
Externí odkaz:
https://doaj.org/article/af67c587f3c6454182698827dbc0676d
Autor:
Lei Sheng, Haoran Xu, Yuexing Wang, Jinhao Ni, Taiyang Xiang, Huanhuan Xu, Xiaozhong Zhou, Kang Wei, Jun Dai
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111157- (2024)
Summary: Nucleus pulposus (NP) resides in hypoxic microenvironment and NP cells (NPCs), primarily reply on glycolysis and producing high levels of lactate. Intracellular lactate drives lysine lactylation (Kla) as a newly epigenetic modification. Howe
Externí odkaz:
https://doaj.org/article/9caa1d795551458fa3408e98fe42ef60
Autor:
Lathan Lucas, Larissa Nitschke, Brandon Nguyen, James A. Loehr, George G. Rodney, Thomas A. Cooper
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111104- (2024)
Summary: Skeletal muscle cells (myofibers) are elongated non-mitotic, multinucleated syncytia that have adapted a microtubule lattice. Microtubule-associated proteins (MAPs) play roles in regulating microtubule architecture. The most abundant MAP in
Externí odkaz:
https://doaj.org/article/b97167ad0f6049e7a56278c345d0f1e0
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110882- (2024)
Summary: P16INK4A expression is inversely associated with RB1 expression in cancer cells, and P16INK4A inhibits CDK4-catalyzed RB1 phosphorylation. How P16INK4A and RB1 coordinately express and regulate the cell cycle remains to be studied. In the pr
Externí odkaz:
https://doaj.org/article/399a45d6120041298ec7054121fe3060
Autor:
Cene Skubic, Hana Trček, Petra Nassib, Tinkara Kreft, Andrew Walakira, Katka Pohar, Sara Petek, Tadeja Režen, Alojz Ihan, Damjana Rozman
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110651- (2024)
Summary: Sterols from cholesterol synthesis are crucial for cholesterol production, but also have individual roles difficult to assess in vivo due to essentiality of cholesterol. We developed HepG2 cell models with knockouts (KOs) for three enzymes o
Externí odkaz:
https://doaj.org/article/ebd81049d2e34d6089edf8afcf668a26
Autor:
Ivan Ramirez-Moral, Alex R. Schuurman, Christine C.A. van Linge, Joe M. Butler, Xiao Yu, Karen de Haan, Sarah van Leeuwen, Alex F. de Vos, Menno D. de Jong, Felipe A. Vieira Braga, Tom van der Poll
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110662- (2024)
Summary: Airway epithelial cells represent the first line of defense against respiratory pathogens. Flagellin drives the motility of many mucosal pathogens and has been suggested as an immune enhancing adjunctive therapeutic in infections of the airw
Externí odkaz:
https://doaj.org/article/819ebe64dbea43b881ff22d0a2d42a13
Autor:
Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110604- (2024)
Summary: Glioblastoma (GB) is the most common primary malignant brain tumor, characterized by resistance to therapy. Despite aggressive treatment options, GB remains an incurable disease. Invasiveness and heterogeneity are key GB features that cannot
Externí odkaz:
https://doaj.org/article/2811208931514fd98a2e14598552201e
Autor:
Vivian Y. Chang, Yuwei He, Samantha Grohe, Morgan R. Brady, Aldi Chan, Rucha S. Kadam, Tiancheng Fang, Amara Pang, Katherine Pohl, Evelyn Tran, Michelle Li, Jenny Kan, Yurun Zhang, Josie J. Lu, Joshua P. Sasine, Heather A. Himburg, Peibin Yue, John P. Chute
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110306- (2024)
Summary: Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid sk
Externí odkaz:
https://doaj.org/article/c1457d4f4fb74ff7af820506ba0c3075
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110196- (2024)
Summary: Stress granules (SGs) are membrane-less cellular compartments which are dynamically assembled via biomolecular condensation mechanism when eukaryotic cells encounter environmental stresses. SGs are important for gene expression and cell fate
Externí odkaz:
https://doaj.org/article/f1305a0206564c0480eb5f5ed1de2903
Autor:
Hua Qu, Xiufei Liu, Jiaran Zhu, Niexia He, Qingshan He, Linlin Zhang, Yuren Wang, Xiaoli Gong, Xin Xiong, Jinbo Liu, Chuan Wang, Gangyi Yang, Qingwu Yang, Gang Luo, Zhiming Zhu, Yi Zheng, Hongting Zheng
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109796- (2024)
Summary: Metabolic diseases such as obesity and diabetes induce lipotoxic cardiomyopathy, which is characterized by myocardial lipid accumulation, dysfunction, hypertrophy, fibrosis and mitochondrial dysfunction. Here, we identify that mitochondrial
Externí odkaz:
https://doaj.org/article/542d068c51524cd59aedf10830676b99