Výsledky vyhledávání - "Cellular Microenvironment / immunology"

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement

Autor: Riddhima Banga, Khalid Ohmiti, Matthieu Perreau, Kalliopi Ioannidou, Laurence de Leval, Francesco A. Procopio, Caterina Rebecchini, Alessandra Noto, Matthias Cavassini, Olivia Munoz, Giuseppe Pantaleo, Craig Fenwick, Jean-Marc Corpataux

Publikováno v: PLoS pathogens, vol. 15, no. 7, pp. e1007918
PLoS Pathogens, Vol 15, Iss 7, p e1007918 (2019)
PLoS Pathogens

T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a75d9b74797de056653603fd5facae8
https://serval.unil.ch/resource/serval:BIB_1FF4BBBC8958.P001/REF.pdf

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Macrophages Down-Regulate Gene Expression of Intervertebral Disc Degenerative Markers Under a Pro-inflammatory Microenvironment

Autor: Ana J. Silva, Joana R. Ferreira, Carla Cunha, João V. Corte-Real, Mafalda Bessa-Gonçalves, Mario A. Barbosa, Susana G. Santos, Raquel M. Gonçalves

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)

Low back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition. Accumulating evidence suggests that inflammation plays a crucial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9ad1bbccd2d526fadbdb46572c9c2f
https://pubmed.ncbi.nlm.nih.gov/31333653

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High proportion of PD-1-expressing CD4 + T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence

Autor: Guillaume Pourcher, Abderaouf Damouche, Benoit Favier, Jean Jacques Lataillade, Bruno Vaslin, Valérie Pourcher, Christine Bourgeois, Elodie Busson, Olivier Lambotte, Mélanie Le Van, Stéphane Benoist, Thierry Lazure, Julien Adam, Michaela Müller-Trutwin

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2017, 47 (12), pp.2113-2123. ⟨10.1002/eji.201747060⟩
European Journal of Immunology, Wiley-VCH Verlag, 2017, 47 (12), pp.2113-2123. ⟨10.1002/eji.201747060⟩

We and others have demonstrated that adipose tissue is a reservoir for HIV. Evaluation of the mechanisms responsible for viral persistence may lead to ways of reducing these reservoirs. Here, we evaluated the immune characteristics of adipose tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfca3eda57bdcf8b871126b640f92b28
https://doi.org/10.1002/eji.201747060

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Environmental and T Cell–Intrinsic Factors Limit the Expansion of Neonatal Follicular T Helper Cells but May Be Circumvented by Specific Adjuvants

Autor: Anne-Françoise Rochat, Paul-Henri Lambert, Fabienne Tacchini-Cottier, Floriane Auderset, Elodie Belnoue, Arun T. Kamath, Béatris Mastelic, Christophe Combescure, Paola Fontannaz, Chantal Tougne, Claire-Anne Siegrist

Publikováno v: J Immunol
Journal of immunology (Baltimore Md. : 1950)
Journal of Immunology, Vol. 189, No 12 (2012) pp. 5764-72

Follicular Th (TFH) cells have emerged as a new Th subset providing help to B cells and supporting their differentiation into long-lived plasma cells or memory B cells. Their differentiation had not yet been investigated following neonatal immunizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a928fe9cebcbb61e4fbd3cc8b17aeb
http://www.jimmunol.org/content/189/12/5764.long

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