Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Cellular DNA damage response"'
Autor:
Joshua Dickerson, Tajhal Dayaram, Margaret A. Goodell, Yolanda F. Darlington, Byung-Kwon Choi, Kenichiro Fujiwara, Lawrence A. Donehower
Publikováno v:
Cell Cycle. 19:479-491
The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibit...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ffece6e3ed322917cf91c90bfa18d4
https://doi.org/10.1080/15384101.2020.1717025
https://doi.org/10.1080/15384101.2020.1717025
Autor:
Maria Rita Fabbrizi, Jason L. Parsons
Publikováno v:
Cancer Drug Resistance
Incidences of head and neck squamous cell carcinoma (HNSCC) have been on the rise in the last few decades, with a significant risk factor being human papillomavirus (HPV) type-16/18 infection, particularly in the development of oropharyngeal cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b293b8bada56211d0eb79f4f414016d9
https://pubmed.ncbi.nlm.nih.gov/35582232
https://pubmed.ncbi.nlm.nih.gov/35582232
Autor:
Cise Kizilirmak, Marc-David Ruepp, Silvia C. Lenzken, Francesca Conte, Marco Antonaci, Oliver Mühlemann, Fabio Biella, Alessia Loffreda, Angela Bachi, Antonella Ronchi, Stefan Reber, Brunno R. Levone, Silvia M.L. Barabino, Giuseppe Filosa
RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid-liquid phase separation (LLPS) in vitro. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8180184497f39eed0c89c98f543a5b54
https://doi.org/10.1101/798884
https://doi.org/10.1101/798884
Autor:
Lucia Nobili, Antonino Neri, Katia Todoerti, Elisa Taiana, Domenica Ronchetti, Pierfrancesco Tassone, Nicola Amodio
Publikováno v:
Non-Coding RNA
Non-Coding RNA, Vol 6, Iss 26, p 26 (2020)
Non-Coding RNA, Vol 6, Iss 26, p 26 (2020)
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2205b7e161e3fcf2bf78b2ed054d3274
https://doi.org/10.3390/ncrna6030026
https://doi.org/10.3390/ncrna6030026
Autor:
Susan Ashwell, James W. Janetka
Publikováno v:
Expert Opinion on Therapeutic Patents. 19:165-197
The checkpoint kinases, Chk1 and Chk2 are Ser/Thr protein kinases, which function as key regulatory kinases in cellular DNA damage response pathways limiting cell-cycle progression in the presence of DNA damage. The development of checkpoint kinase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d56ad03e275155c3215458dc957b6b
https://doi.org/10.1517/13543770802653622
https://doi.org/10.1517/13543770802653622
Publikováno v:
Viruses
Viruses, Vol 9, Iss 11, p 323 (2017)
Viruses, Vol 9, Iss 11, p 323 (2017)
Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9081d680517faa2e6a9e7f4d0ec6dc
https://doi.org/10.3390/v9110323
https://doi.org/10.3390/v9110323
Publikováno v:
Cell Cycle Checkpoints ISBN: 9781617792724
Maintenance of genomic integrity is critical for the survival of organisms. Thus, mammalian cells employ a complex DNA damage response that can sense and repair DNA damage. One important aspect of the cellular DNA damage response is the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7e9a6c0c2907b47cc883d53589f77e
https://pubmed.ncbi.nlm.nih.gov/21870295
https://pubmed.ncbi.nlm.nih.gov/21870295
Autor:
Thomas Ludwig, Mario Scarpa, Carlo M. Croce, Rexhep Uka, Timothy Richmond, Foued Amari, Tyler Sheetz, Vincenzo Coppola, Jeffrey D. Parvin, Dario Palmieri, Cindy Lee, Anna Tessari
Publikováno v:
Cancer Research. 75:LB-164
Currently, most of the anti-neoplastic treatments for lung cancer patients are based on DNA-damaging cytotoxic therapies such as platinum-containing compounds and radiotherapy. Therefore, a better understanding of the molecular mechanisms involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291d6dac2b3296700e36832125b43ebc
https://doi.org/10.1158/1538-7445.am2015-lb-164
https://doi.org/10.1158/1538-7445.am2015-lb-164
Autor:
Ryan P. Smith, Gary D. Kao
Publikováno v:
Cancer biologytherapy. 3(7)
An unexpected image made by an invisible beam precipitated the discovery of X-rays in the waning days of the 19th century. The usefulness and dangers of this new discovery soon became clear, emphasizing the importance of DNA damage recognition and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a84a9813947203043e8cbf08cd12f8b
https://pubmed.ncbi.nlm.nih.gov/15153811
https://pubmed.ncbi.nlm.nih.gov/15153811