Zobrazeno 1 - 10
of 1 916
pro vyhledávání: '"Cell of origin"'
A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer
Autor:
Mohamed Omar, J. Chuck Harrell, Rulla Tamimi, Luigi Marchionni, Cihat Erdogan, Harikrishna Nakshatri, Tan A. Ince
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-16 (2024)
Abstract Background Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable insights has been challenging. This study introduces breast cancer cell-of-
Externí odkaz:
https://doaj.org/article/8a2eb70994dd4c63a4786f5a0770dfac
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102085- (2024)
Clinical genomic profiling of cell-free nucleic acids (e.g. cell-free DNA or cfDNA) from blood and other body fluids has ushered in a new era in non-invasive diagnostics and treatment monitoring strategies for health conditions and diseases such as c
Externí odkaz:
https://doaj.org/article/465dada5becb4dcab0d927ede25d3f18
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionGlioma, a prevalent and deadly brain tumor, is marked by significant cellular heterogeneity and metabolic alterations. However, the comprehensive cell-of-origin and metabolic landscape in high-grade (Glioblastoma Multiforme, WHO grade IV)
Externí odkaz:
https://doaj.org/article/cd38dbf2ad854c519aa93157fe8773e2
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundCancer stem cells (CSCs) have emerged as pivotal players in tumorigenesis, disease progression, and resistance to therapies.ObjectiveThis comprehensive review delves into the intricate relationship between CSCs and the cell-of-origin in div
Externí odkaz:
https://doaj.org/article/8a10a6b28dcc4bffb5094e53088237b0
Autor:
Helge Waldum, Geir Slupphaug
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Malignancy manifests itself by deregulated growth and the ability to invade surrounding tissues or metastasize to other organs. These properties are due to genetic and/or epigenetic changes, most often mutations. Many aspects of carcinogenesis are kn
Externí odkaz:
https://doaj.org/article/041b208cc64b43449737c4d2e97884e7
Publikováno v:
Cell Regeneration, Vol 12, Iss 1, Pp 1-12 (2023)
Abstract Nervous system cancers are the 10th leading cause of death worldwide, many of which are difficult to diagnose and exhibit varying degrees of treatment resistance. The limitations of existing cancer models, such as patient-derived xenograft (
Externí odkaz:
https://doaj.org/article/a2a184ae13854266a89f5d00f6def978
Autor:
Nicholas Dcunha, Dhananjayan Sakhti, Elanthendral Sigamani, Jagan Chandramohan, Anu Korula, Biju George, Marie Therese Manipadam, Rekha Pai
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 66, Iss 4, Pp 714-719 (2023)
Classifying diffuse large B cell lymphomas, not otherwise specified (DLBCL, NOS), is based on their cell-of-origin (COO) which is included in the WHO classification (2016), is essential to characterize them better in context of prognostication. While
Externí odkaz:
https://doaj.org/article/ceb78ba6d9cf46dc915d12d7c86bc54e
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-19 (2023)
Abstract Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are devastating primary liver cancers with increasing prevalence in many parts of the world. Despite intense investigation, many aspects of their biology are still largely obscure.
Externí odkaz:
https://doaj.org/article/e59b2d2697c644ed8accd742163dcd89
Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses
Autor:
Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-22 (2022)
Abstract Keratinocyte cancers (KC) are the most prevalent malignancies in fair‐skinned populations, posing a significant medical and economic burden to health systems. KC originate in the epidermis and mainly comprise basal cell carcinoma (BCC) and
Externí odkaz:
https://doaj.org/article/f1877efb7d4b4f92a9c149e53c79c250
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
We have established a pseudotemporal ordering for the transcriptional signatures of distinct microregions within reactive lymphoid tissues, namely germinal center dark zones (DZ), germinal center light zones (LZ), and peri-follicular areas (Peri). By
Externí odkaz:
https://doaj.org/article/e042b52e459442c6b80bfa9002208b4d