Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing

Autor: Marco Andrey Cipriani Frade, Lúcia Helena Faccioli, Guilherme Ferreira Caetano, Claudia da Silva Bitencourt, Marcio Fronza, Irmgard Merfort, Francisco Wanderley Garcia Paula-Silva, Marcel Nani Leite, Thiago Antônio Moretti de Andrade

Publikováno v: PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 9, Iss 11, p e112297 (2014)

Hyaluronidases are enzymes that degrade hyaluronan an important constituent of the extracellular matrix. They have been used as a spreading agent, improving the absorption of drugs and facilitating the subcutaneous infusion of fluids. Here, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28eceb11e4d92e31e20eb943d546fa61
http://europepmc.org/articles/PMC4230982

The p21-Activated Kinase (PAK) Family Member PakD Is Required for Chemorepulsion and Proliferation Inhibition by Autocrine Signals in Dictyostelium discoideum

Autor: Richard H. Gomer, Jonathan E. Phillips

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 5, p e96633 (2014)

In Dictyostelium discoideum, the secreted proteins AprA and CfaD function as reporters of cell density and regulate cell number by inhibiting proliferation at high cell densities. AprA also functions to disperse groups of cells at high density by act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7873cf3ffc6a68a5ed7c8b477695663
http://europepmc.org/articles/PMC4010531

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

Autor: Mark O. Collins, Jyoti S. Choudhary, Frank Schwach, David A. Baker, Oliver Billker, Mathieu Brochet, Sarah Sebastian, Eloise Thompson, Terry K. Smith, Julian C. Rayner, Katrin Volkmann, Lia Chappell, Ana Rita Gomes, Matthew Berriman

Publikováno v: PLoS Biology

Chemical genetics and a global comparative analysis of phosphorylation and phospholipids in vivo shows that PKG is the upstream regulator that induces calcium signals that enables Plasmodium to progress through its complex life cycle.
Many criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c792bb6c970837aeed6d45c3e4297437
http://europepmc.org/articles/PMC3942320

The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior

Autor: Katerina D. Fagan-Solis, Jodie M. Fleming, Karen A. Dunphy, Shannon D. Oliver, Denise K. Reaves, David W. Scott

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91747 (2014)
PLoS ONE

The claudin-low molecular subtype of breast cancer is of particular interest for clinically the majority of these tumors are poor prognosis, triple negative, invasive ductal carcinomas. Claudin-low tumors are characterized by cancer stem cell-like fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679c0c2c95c4fbe74d529e8bba25d119
http://europepmc.org/articles/PMC3956714?pdf=render

A new genetically encoded single-chain biosensor for Cdc42 based on FRET, useful for live-cell imaging

Autor: Veronika Miskolci, Dianne Cox, Louis Hodgson, Samer Hanna

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96469 (2014)
PLoS ONE

Cdc42 is critical in a myriad of cellular morphogenic processes, requiring precisely regulated activation dynamics to affect specific cellular events. To facilitate direct observations of Cdc42 activation in live cells, we developed and validated a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327a84a56cf81a407788ffb4f3a3b890
http://europepmc.org/articles/PMC4010534?pdf=render