Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Cell line models"'
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 3, Pp 297-320 (2022)
The development of endocrine resistance is a common reason for the failure of endocrine therapies in hormone receptor-positive breast cancer. This review provides an overview of the different types of in vitro models that have been developed as tools
Externí odkaz:
https://doaj.org/article/9fda8b6e94c341e9848e2e33c8f69877
Autor:
Ioannis A. Voutsadakis
Publikováno v:
Medicina, Vol 58, Iss 10, p 1498 (2022)
Background: Colorectal cancer represents a common malignancy and remains incurable in the metastatic stage. Identification of molecular alterations that are present in colorectal cancer has led to the introduction of targeted therapies that improve o
Externí odkaz:
https://doaj.org/article/5ae1770a07d348098bea87f25898cefb
Autor:
Amélia M. Silva, Carlos Martins-Gomes, Tânia L. Silva, Tiago E. Coutinho, Eliana B. Souto, Tatiana Andreani
Publikováno v:
Toxics, Vol 10, Iss 7, p 378 (2022)
In this work, three pesticides of different physicochemical properties, namely, glyphosate (herbicide), imidacloprid (insecticide) and imazalil (fungicide), were selected to assess their cytotoxicity against distinct cell models (Caco-2, HepG2, A431,
Externí odkaz:
https://doaj.org/article/e2fc2f8e9f3d413d93627288f395113f
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Antiapoptotic members of B-cell leukemia/lymphoma-2 (BCL-2) family proteins are one of the overexpressed proteins in cancer cells that are oncogenic targets. As such, targeting of BCL-2 family proteins raises hopes for new therapeutic discoveries. Th
Externí odkaz:
https://doaj.org/article/d6d913ea9c3143c1a13f3237452571d3
Autor:
Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty, Celina M. D’Cruz
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-7 (2017)
Abstract Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have emerged as valuable tools for tran
Externí odkaz:
https://doaj.org/article/35d4fe6ac1204c65ab4eca774df20d90
Publikováno v:
Cells, Vol 10, Iss 2, p 354 (2021)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are first-line drugs for lung cancers with activating EGFR mutations. Although first- and second-generation EGFR-TKIs were standard first-line treatments, acquired resistance (
Externí odkaz:
https://doaj.org/article/a5f9a0e89ddd45508e0c9c3a22fb0b6f
Akademický článek
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Akademický článek
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Autor:
Murat Iskar, Georg Zeller, Peter Blattmann, Monica Campillos, Michael Kuhn, Katarzyna H Kaminska, Heiko Runz, Anne‐Claude Gavin, Rainer Pepperkok, Vera van Noort, Peer Bork
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-13 (2013)
Abstract In pharmacology, it is crucial to understand the complex biological responses that drugs elicit in the human organism and how well they can be inferred from model organisms. We therefore identified a large set of drug‐induced transcription
Externí odkaz:
https://doaj.org/article/9478002f54924c62a01731099796f2c2
Akademický článek
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