HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling

Autor: Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa

Bone remodeling is a continuous process between bone-forming osteoblasts and bone-resorbing osteoclasts, with any imbalance resulting in metabolic bone disease, including osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ded356ccd344b440a123f1de15f65d
http://hdl.handle.net/2445/195231

Generation and validation of a CRISPR platform for rapid and inducible genome editing in human pluripotent stem cells and kidney organoids

Autor: Marco Giménez, Andrés, 1993

Publikováno v: TDX (Tesis Doctorals en Xarxa)
TDR. Tesis Doctorales en Red
instname

Our current knowledge about the function of human genes is mostly based on data from genetic studies using animal models. However, divergence among species may hamper the understanding of genetic mechanisms underlying human specific traits. Nowadays,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::0b74a8613fa386abc1e6bd1d136a8453
http://hdl.handle.net/10803/673798

A microRNA cluster controls fat cell differentiation and adipose tissue expansion by regulating SNCG

Autor: Ruth Rodríguez‐Barrueco, Jessica Latorre, Laura Devis‐Jáuregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll‐Iglesias, Katja Gassner, Meredith L. Davis, José M. Moreno‐Navarrete, Anna Castells‐Nobau, Laura Plata‐Peña, Miki Dalmau‐Pastor, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga‐Rodríguez, Wifredo Ricart, José M. Fernández‐Real, José M. Silva, Francisco J. Ortega, David Llobet‐Navas

Publikováno v: Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Dipòsit Digital de la UB
Universidad de Barcelona

The H19X-encoded miR-424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity, while incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd31ca7603b3f84c28bd2b992ec8e2bb
http://hdl.handle.net/2445/189979

Galectina-3 em Pacientes com Pericardite Constritiva Crônica

Autor: Felix José Alvarez Ramires, Viviane Tiemi Hotta, Fábio Fernandes, Ester Cerdeira Sabino, Ricardo Ribeiro Dias, Carlos Henrique Valente Moreira, Charles Mady, Francis Ribeiro de Souza, Luiz Alberto Benvenutti, Dirceu Thiago Pessoa de Melo, Ana Luiza Carrari Sayegh

Publikováno v: Arquivos Brasileiros de Cardiologia v.114 n.4 2020
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Vol 114, Iss 4, Pp 683-689
Arquivos Brasileiros de Cardiologia, Volume: 114, Issue: 4, Pages: 683-689, Published: 29 MAY 2020

Resumo Fundamento A galectina-3 (Gal-3) é uma molécula pró-inflamatória e pró-fibrótica, envolvida na patogênese da insuficiência cardíaca. O papel da Gal-3 em pacientes com pericardite constritiva crônica (PCC) não está claro. Objetivo O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88916c95c1a0277143a9c1713ef7f97
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2020000400683

Clonagem e análise da expressão do fator de transcrição Scratch2 durante a embriogênese inicial de galinha.

Autor: Vieceli, Felipe Monteleone

Em invertebrados, os genes Scratch (Scrt) codificam fatores de transcrição que promovem a neurogênese durante o desenvolvimento. A função de Scrt em vertebrados é desconhecida, mas em camundongos Scrt1 e Scrt2 são especificamente expressos em

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/42/42134/tde-02022010-112918/