Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Cell Surface/metabolism"'
Autor:
Nathaniel John Himmel, Richard Benton
Publikováno v:
PLoS biology, vol. 20, no. 7, pp. e3001705
Gustatory receptors (Grs) are well known for their functions in sensory neurons in detecting food and toxins. An intriguing new study in PLOS Biology provides evidence for a role for Grs in Drosophila epithelia in protecting stressed cells from prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021c1b1da13046ac6db576bc90ff254b
https://serval.unil.ch/resource/serval:BIB_30CC35FC55DE.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_30CC35FC55DE.P001/REF.pdf
Autor:
Marc Hoylaerts, Marleen Lox, Laurens Liesenborghs, Thomas Vanassche, Christophe Vandenbriele, Elizabeth A. V. Jones, Maarten Criel, Peter Verhamme, Katrien Cludts, Soetkin Van kerckhoven, Benedetta Izzi
Publikováno v:
Thrombosis Research, 146, 76-83. Elsevier Science
Background Platelet Endothelial Aggregation Receptor-1 (PEAR1) is a transmembrane platelet receptor that amplifies the activation of the platelet fibrinogen receptor (αIIbβ3) during platelet aggregation. In man, Pear1 polymorphisms are associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17807d10dc9577782487e704d1576e8c
https://doi.org/10.1016/j.thromres.2016.08.026
https://doi.org/10.1016/j.thromres.2016.08.026
Autor:
Gregory G. Putzel, David Artis, Jesper B. Moeller, Irina Leonardi, Iliyan D. Iliev, Christine Elise Schøler Jepsen, Ernst-Martin Füchtbauer, Nicholas J. Bessman, Karsten Skjødt, Anders Schlosser, Mark Hammond, Grith Lykke Sørensen, Theresa Thomsen, Uffe Holmskov, Anne-Laure Flamar, Donna L. Farber
Publikováno v:
Moeller, J B, Leonardi, I, Schlosser, A, Flamar, A-L, Bessman, N J, Putzel, G G, Thomsen, T, Hammond, M, Jepsen, C S, Skjødt, K, Füchtbauer, E-M, Farber, D L, Sorensen, G L, Iliev, I D, Holmskov, U & Artis, D 2019, ' Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 ', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700 . https://doi.org/10.1084/jem.20182244
The Journal of Experimental Medicine
Moeller, J B, Leonardi, I, Schlosser, A, Flamar, A L, Bessman, N J, Putzel, G G, Thomsen, T, Hammond, M, Jepsen, C S, Skjødt, K, Füchtbauer, E M, Farber, D L, Sorensen, G L, Iliev, I D, Holmskov, U & Artis, D 2019, ' Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 ', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700 . https://doi.org/10.1084/jem.20182244
The Journal of Experimental Medicine
Moeller, J B, Leonardi, I, Schlosser, A, Flamar, A L, Bessman, N J, Putzel, G G, Thomsen, T, Hammond, M, Jepsen, C S, Skjødt, K, Füchtbauer, E M, Farber, D L, Sorensen, G L, Iliev, I D, Holmskov, U & Artis, D 2019, ' Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1 ', The Journal of Experimental Medicine, vol. 216, no. 12, pp. 2689-2700 . https://doi.org/10.1084/jem.20182244
In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85339131815355f437b5bc445395583b
https://findresearcher.sdu.dk:8443/ws/files/169995901/Open_Access_version
https://findresearcher.sdu.dk:8443/ws/files/169995901/Open_Access_version
Autor:
Coert Margadant, Martijn A. Nolte
Publikováno v:
Blood. 135(1)
Integrins are a large family of heterodimeric cell surface receptors that bind prototypic ligands on neighboring cells or in the extracellular matrix. Numerous studies have revealed key roles for platelet and leukocyte integrins in adhesion and migra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a596194dd88301aba8e6644cd13dfae
https://pubmed.ncbi.nlm.nih.gov/31730155
https://pubmed.ncbi.nlm.nih.gov/31730155
Publikováno v:
Juul, C B, Fedosov, S, Nexø, E & Heegaard, C W 2019, ' Kinetic analysis of transcellular passage of the cobalamin-transcobalamin complex in Caco-2 monolayers ', Molecular Biology of the Cell, vol. 30, no. 4, pp. 467-477 . https://doi.org/10.1091/mbc.E18-09-0571
Molecular Biology of the Cell
Molecular Biology of the Cell
We suggest a novel kinetic approach to quantifying receptor–ligand interactions via the cellular transport and/or accumulation of the ligand. The system of cobalamin (Cbl, vitamin B12) transport was used as a model, because Cbl is an obligatory cof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0eb2368b39d46c47e7821fcaa60d524
https://pure.au.dk/portal/da/publications/kinetic-analysis-of-transcellular-passage-of-the-cobalamintranscobalamin-complex-in-caco2-monolayers(eee8dcbb-80ad-4c99-846c-1c35fb04936c).html
https://pure.au.dk/portal/da/publications/kinetic-analysis-of-transcellular-passage-of-the-cobalamintranscobalamin-complex-in-caco2-monolayers(eee8dcbb-80ad-4c99-846c-1c35fb04936c).html
Autor:
Van Der Klaauw, AA, Croizier, S, De Oliveira, E, Stadler, LKJ, Park, S, Kong, Y, Banton, MC, Tandon, P, Hendricks, AE, Keogh, JM, Riley, SE, Papadia, S, Henning, E, Bounds, R, Bochukova, EG, Mistry, V, O'Rahilly, S, Simerly, RB, Interval, Consortium, Uk10K, Minchin, JEN, Barroso, I, Jones, EY, Bouret, SG, Farooqi, IS
Publikováno v:
Cell
Cell, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Van Der Klaauw, A A, Croizier, S, Mendes De Oliveira, E, Stadler, L K J, Park, S, Kong, Y, Banton, M C, Tandon, P, Hendricks, A E, Keogh, J M, Riley, S E, Papadia, S, Henning, E, Bounds, R, Bochukova, E G, Mistry, V, O’rahilly, S, Simerly, R B, Minchin, J E N, Barroso, I & Jones, E Y & Bouret, S G & Farooqi, I S 2019, ' Human semaphorin 3 variants link melanocortin circuit development and energy balance ', Cell, vol. 176, no. 4, pp. 729-742 . https://doi.org/10.1016/j.cell.2018.12.009
Cell, Elsevier, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Cell, vol. 176, no. 4, pp. 729-742.e18
Cell, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Van Der Klaauw, A A, Croizier, S, Mendes De Oliveira, E, Stadler, L K J, Park, S, Kong, Y, Banton, M C, Tandon, P, Hendricks, A E, Keogh, J M, Riley, S E, Papadia, S, Henning, E, Bounds, R, Bochukova, E G, Mistry, V, O’rahilly, S, Simerly, R B, Minchin, J E N, Barroso, I & Jones, E Y & Bouret, S G & Farooqi, I S 2019, ' Human semaphorin 3 variants link melanocortin circuit development and energy balance ', Cell, vol. 176, no. 4, pp. 729-742 . https://doi.org/10.1016/j.cell.2018.12.009
Cell, Elsevier, 2019, 176 (4), pp.729-742.e18. ⟨10.1016/j.cell.2018.12.009⟩
Cell, vol. 176, no. 4, pp. 729-742.e18
Summary Hypothalamic melanocortin neurons play a pivotal role in weight regulation. Here, we examined the contribution of Semaphorin 3 (SEMA3) signaling to the development of these circuits. In genetic studies, we found 40 rare variants in SEMA3A-G a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80eb92bc3fd4ba670283a473e22557d3
https://hal.science/hal-02375383/file/S0092867418316234.pdf
https://hal.science/hal-02375383/file/S0092867418316234.pdf
Autor:
François Couderc, Camille Alric, Christophe Dardenne, Bettina Couderc, Bruno Ségui, José Bernad, Lise Lefèvre, Mélissa Prat, Bernard Pipy, Etienne Meunier, Agnès Coste, Patricia Balard, Laurent Alric, Hélène Authier, Véréna Poinsot, Mohamad Alaeddine, Valérie Gouazé-Andersson
Publikováno v:
Cancer Immunology Research
Cancer Immunology Research, American Association for Cancer Research, 2019, ⟨10.1158/2326-6066.CIR-18-0213⟩
Cancer Immunology Research, 2019, ⟨10.1158/2326-6066.CIR-18-0213⟩
Cancer Immunology Research, American Association for Cancer Research, 2019, ⟨10.1158/2326-6066.CIR-18-0213⟩
Cancer Immunology Research, 2019, ⟨10.1158/2326-6066.CIR-18-0213⟩
Macrophage-mediated cytotoxicity is controlled by surface receptor expression and activation. Despite the numerous studies documenting the role of macrophage C-type lectin receptors (CLR) in pathogen elimination, little is known about their contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597fe2b756836ba339dd007adcd2a9c5
https://hal.archives-ouvertes.fr/hal-02194445
https://hal.archives-ouvertes.fr/hal-02194445
Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment
Autor:
Albert E. Jergens, Cameron J. Nowell, Lina Maria Martinez Lopez, Wayne G. Kimpton, Caroline S Mansfield, Andrew Stent, Karin Allenspach, Julien R.S. Dandrieux, Simon M. Firestone
Publikováno v:
Innate Immunity
Dandrieux, J R, Martinez Lopez, L M, Stent, A, Jergens, A, Allenspach, K, Nowell, C J, Firestone, S M, Kimpton, W & Mansfield, C S 2018, ' Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment ', Innate Immunity, vol. 24, no. 7, pp. 400-410 . https://doi.org/10.1177/1753425918799865
Dandrieux, J R, Martinez Lopez, L M, Stent, A, Jergens, A, Allenspach, K, Nowell, C J, Firestone, S M, Kimpton, W & Mansfield, C S 2018, ' Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment ', Innate Immunity, vol. 24, no. 7, pp. 400-410 . https://doi.org/10.1177/1753425918799865
Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) – the latter most resembling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bbebd05acc0035ca6fa6a50e277887
https://pubmed.ncbi.nlm.nih.gov/30223681
https://pubmed.ncbi.nlm.nih.gov/30223681
Autor:
Wenbin Wang, Nathanael S. Gray, Adam J. Pearson, William Vermi, Zhengui Xia, Katherine G. Finegan, Jinhua Wang, Ilaria Russo, Silvia Lonardi, Cathy Tournier, Qiuping Xu, Brian A. Telfer, Emanuele Giurisato
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Giurisato, E, Xu, Q, Lonardi, S, Telfer, B, Russo, I, Pearson, A, Finegan, K, Wang, W, Wang, J, Gray, N S, Vermi, W, Xia, Z & Tournier, C 2018, ' Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition ', Proceedings of the National Academy of Sciences, vol. 115, no. 12, pp. E2801-E2810 . https://doi.org/10.1073/pnas.1707929115
Giurisato, E, Xu, Q, Lonardi, S, Telfer, B, Russo, I, Pearson, A, Finegan, K, Wang, W, Wang, J, Gray, N S, Vermi, W, Xia, Z & Tournier, C 2018, ' Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition ', Proceedings of the National Academy of Sciences, vol. 115, no. 12, pp. E2801-E2810 . https://doi.org/10.1073/pnas.1707929115
Significance Macrophages can be functionally reprogrammed by the tumor microenvironment to further tumor growth and malignancy. In this study, we have discovered that this pathological process is dependent on the ERK5 MAPK. Accordingly, we demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d62af4140b663639014d420c46470
http://hdl.handle.net/11379/537884
http://hdl.handle.net/11379/537884
Autor:
Roth, Ronelle, Chiapello, Marco, Montero, Héctor, Gehrig, Peter, Grossmann, Jonas, O’Holleran, Kevin, Hartken, Denise, Walters, Fergus, Yang, Shu-Yi, Hillmer, Stefan, Schumacher, Karin, Bowden, Sarah, Craze, Melanie, Wallington, Emma J., Miyao, Akio, Sawers, Ruairidh, Martinoia, Enrico, Paszkowski, Uta
Publikováno v:
Nature Communications, 9 (1)
Nature communications, vol. 9, no. 1, pp. 4677
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature communications, vol. 9, no. 1, pp. 4677
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
In terrestrial ecosystems most plant species live in mutualistic symbioses with nutrient-delivering arbuscular mycorrhizal (AM) fungi. Establishment of AM symbioses includes transient, intracellular formation of fungal feeding structures, the arbuscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c764082fb099f71a3ec448f522bb4b7b