Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Cell Signaling and Signaling Pathways"'
Autor:
Tom Mikkelsen, Susan Irtenkauf, Laura Hasselbach, Ana C de Carvalho, Andrea D. Transou, Artem D. Berezovsky
Publikováno v:
Neuro Oncol
Activated platelet derived growth factor receptor alpha (PDGFRα) is essential for the maintenance of oligodendrocyte progenitors. Differential signaling results from phosphorylation of specific tyrosine residues in the kinase insert (KI) domain pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9836ed85326793dd445ea7cdb17094
https://europepmc.org/articles/PMC7651131/
https://europepmc.org/articles/PMC7651131/
Publikováno v:
Neuro Oncol
Our group found that the inhibitory effect of TRPM7 on proliferation and invasion of human glioma cell is mediated by multiple mechanisms. TRPM7 regulates miR-28-5p expression, which suppresses cell proliferation and invasion in glioma cells by targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b99792a51f928ab87f09481f1be95f
https://europepmc.org/articles/PMC7650375/
https://europepmc.org/articles/PMC7650375/
Autor:
Gary L. Johnson, Ryan Bash, Abigail Shelton, Erin Smithberger, Michael P. East, Steven Angus, C. Ryan Miller, Frank B. Furnari, Madison Butler, Michael E. Berens, Allie Stamper
Publikováno v:
Neuro Oncol
Glioblastoma (GBM) is an aggressive primary brain tumor with poor survival and limited treatment options. However, it is an attractive candidate for precision therapeutic approaches due to the frequency of amplification and/or activating mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba47ea7bf08b0f9c3d807b6c74147983
https://europepmc.org/articles/PMC7650463/
https://europepmc.org/articles/PMC7650463/
Publikováno v:
Neuro Oncol
OBJECTIVES Tumor Treating Fields (TTFields) are approved in combination with temozolomide for newly diagnosed glioblastoma (GBM). TTFields are low-intensity alternating electric fields that are thought to disturb mitotic macromolecules’ assembly. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a901d4b86613e1ca516f683ef11b85d
https://europepmc.org/articles/PMC7650312/
https://europepmc.org/articles/PMC7650312/
Autor:
Rashmi Budhathoki, Claire Peabody, Sandra Camelo-Piragua, Thomas L. Saunders, Philip Chi-En Huang, Ester Calvo Fernandez, Tao Xu, Elizabeth D. Hughes, Brian Magnuson, Jean François Rual, Rork Kuick, Honglai Zhang
Publikováno v:
Neuro Oncol
The NOTCH/RBPJ pathway governs cell proliferation in many biological contexts, including SHH and Group#3medulloblastoma (MB) tumorigenesis. Using our proteomic platform, we discovered an interaction between RBPJ, a key co-factor of NOTCH for the modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e110b90a2bf30a695d79ba08dcdc5c
https://europepmc.org/articles/PMC7650321/
https://europepmc.org/articles/PMC7650321/
Publikováno v:
Neuro Oncol
BMI-1 is a transcriptional repressor and overexpresses in various human cancer tissues, which is also known to involve in the maintenance of “stem cell” features in a cell sub-population within the tumor. Here, we investigate the roles of BMI1 on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab04a7725b7e58dc8f8eece81bad211
https://europepmc.org/articles/PMC7650497/
https://europepmc.org/articles/PMC7650497/
Autor:
Alan Nguyen, Darryl Lau, Arman Jahangiri, Garima Yagnik, Ankush Chandra, Justin Cheng, Manish K. Aghi, Michael Safaee, Sweta Sudhir, Jordan Spatz, Harsh Wadhwa, Sumedh S. Shah, Saket Jain
Publikováno v:
Neuro Oncol
Metastases cause 90% of human cancer deaths. The metastatic cascade involves 5 steps: local invasion, intravasation, extravasation, metastatic site colonization, and proliferation. While individual mediators of these processes have been investigated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda377b1a36a2e9c8a2ca4adaf4beae7
https://europepmc.org/articles/PMC7650478/
https://europepmc.org/articles/PMC7650478/
Publikováno v:
Neuro Oncol
BACKGROUND Alterations in the NF2 tumor suppressor gene lead to meningiomas and schwannomas, but the tumor suppressor functions of the NF2 gene product, Merlin, are incompletely understood. To address this problem, we performed a structure-function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323a41ce91bb86dbc78b7d6f9ea21ae6
https://europepmc.org/articles/PMC7650509/
https://europepmc.org/articles/PMC7650509/
Autor:
Amanda M. Prechtl, Shannon M. Weber, Steven L. Carroll, Stephen Barnes, Nicole Brossier, Stephanie Brosius, Landon Wilson
Publikováno v:
Neuro Oncol
Loss of the Ras GTPase-activating protein neurofibromin promotes the development of aggressive spindle cell neoplasms known as Malignant Peripheral Nerve Sheath Tumors (MPNSTs) in patients with the genetic disorder neurofibromatosis type 1 (NF1). Cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf95a1b6093801ec237f9089f148e4f5
https://europepmc.org/articles/PMC7650503/
https://europepmc.org/articles/PMC7650503/
Publikováno v:
Neuro Oncol
Medulloblastoma, the most common malignant brain tumor in children, is a diverse and heterogeneous disease. Molecular characterization of MB revealed four major subgroups, WNT, SHH, Group 3, and Group 4. Although surgical resection, radiotherapy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2842e5d57537cff14969b862da6c5027
https://europepmc.org/articles/PMC7650512/
https://europepmc.org/articles/PMC7650512/