Výsledky vyhledávání - "Cell Respiration/physiology"

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

Autor: Vladimir V. Sharoyko, Peter Spégel, Claes B. Wollheim, Cecilia Nagorny, Lotta Andersson, Geoffrey W. G. Sharp, Thomas Koeck, Siri Malmgren, Isabel Goehring, Anders P. H. Danielsson, Hindrik Mulder, Susanne G. Straub

Publikováno v: Biochemical Journal, Vol. 450, No 3 (2013) pp. 595-605

Insulin secretion is coupled with changes in β-cell metabolism. To define this process, 195 putative metabolites, mitochondrial respiration, NADP+, NADPH and insulin secretion were measured within 15 min of stimulation of clonal INS-1 832/13 β-cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce6ae2ded1ff94d7f983733cfab63ef
https://archive-ouverte.unige.ch/unige:33559

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Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

Autor: Helene Perreten, Patrick A. Keller, Pedro Luis Herrera, Claes B. Wollheim, Asllan Gjinovci, Nathalie Davis-Lameloise, Nathalie Produit-Zengaffinen, Françoise Assimacopoulos-Jeannet, Patrick Muzzin, Dominique Becard

Publikováno v: Diabetologia, Vol. 50, No 1 (2007) pp. 84-93

AIMS/HYPOTHESIS: Levels of uncoupling protein-2 (UCP2) are regulated in the pancreatic beta cells and an increase in the protein level has been associated with mitochondrial uncoupling and alteration in glucose-stimulated insulin secretion. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25464da8da228b0d3ba3c3cfada59ece
https://pubmed.ncbi.nlm.nih.gov/17131143

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