SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

Autor: Anne E. Kiltie, Chee Kin Then, Sophie Ellermann, J.A. Newman, Junetha Syed, Ignacio Torrecilla, Iolanda Vendrell, Kristijan Ramadan, Juri Na, Roman Fischer

Publikováno v: Cell Death & Disease
Cell death & disease, 12(2). Nature Publishing Group
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)

The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e55e65e62a3c0343b3c0eabc9e8bfa
https://doi.org/10.1038/s41419-021-03437-w

Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure

Autor: Valentina Melfi, Peter A. Greer, Adam J Reid, Valerio Magnaghi, Nico Mitro, Alessandra Colciago, Veronica Bonalume, Tasnim Mohamed, Alessandro Faroni, Matteo Audano

Publikováno v: Cells, Vol 10, Iss 1840, p 1840 (2021)
Cells
Volume 10
Issue 7
Colciago, A, Audano, M, Bonalume, V, Melfi, V, Mohamed, T, Reid, A J, Faroni, A, Greer, P A, Mitro, N & Magnaghi, V 2021, ' Transcriptomic Profile Reveals Deregulation of Hearing-Loss Related Genes in Vestibular Schwannoma Cells Following Electromagnetic Field Exposure ', Cells, vol. 10, no. 7, 1840 . https://doi.org/10.3390/cells10071840

Hearing loss (HL) is the most common sensory disorder in the world population. One common cause of HL is the presence of vestibular schwannoma (VS), a benign tumor of the VIII cranial nerve, arising from Schwann cell (SC) transformation. In the last

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a0cb440c36120d1a9d95398e2d30d7
https://doi.org/10.3390/cells10071840

Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy

Autor: Olivier Zava, Frédéric Schmitt, Padavattan Govindaswamy, Georg Süss-Fink, Lucienne Juillerat-Jeanneret, Bruno Therrien

Publikováno v: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, vol. 14, no. 1, pp. 101-109

Mononuclear 5-(4-pyridyl)-10,15,20-triphenylporphyrin and 5-(3-pyridyl)-10,15,20-triphenylporphyrin as well as tetranuclear 5,10,15,20-tetra(4-pyridyl)porphyrin (tetra-4-pp) and 5,10,15,20-tetra(3-pyridyl)porphyrin) (tetra-3-pp) arene ruthenium(II) d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e1f65a2d32ce211e6691c9404e3cca
https://doi.org/10.1007/s00775-008-0427-y

Low-frequency pulsed electromagnetic fields significantly improve time of closure and proliferation of human tendon fibroblasts

Autor: Seeliger, Claudine, Falldorf, Karsten, Sachtleben, Jens, Griensven, Martijn van

Publikováno v: European Journal of Medical Research, 19. BioMed Central

BACKGROUND: The promotion of the healing process following musculoskeletal injuries comprises growth factor signalling, migration, proliferation and apoptosis of cells. If these processes could be modulated, the healing of tendon tissue may be marked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b769a66ac2ae7ec27e54fd365984ab7e
https://cris.maastrichtuniversity.nl/en/publications/aeee569f-b88e-4fe5-830c-6d3cdf2ba993

RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells

Autor: Michael A. Grotzer, Christoph Oehler-Jänne, Tarek Shalaby, Martin Pruschy, Alexandre Arcaro, Duncan Stearns, Charles G. Eberhart, Lucia Arnold, André O. von Bueren

Publikováno v: BMC Cancer
BMC cancer, Vol. 9 (2009) P. 10
von Bueren, André O; Shalaby, Tarek; Oehler-Jänne, Christoph; Arnold, Lucia; Stearns, Duncan; Eberhart, Charles G; Arcaro, Alexandre; Pruschy, Martin; Grotzer, Michael A (2009). RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio-and chemotherapy in childhood medulloblastoma cells. BMC cancer, 9, p. 10. London: BioMed Central 10.1186/1471-2407-9-10
BMC Cancer, Vol 9, Iss 1, p 10 (2009)

BackgroundWith current treatment strategies, nearly half of all medulloblastoma (MB) patients die from progressive tumors. Accordingly, the identification of novel therapeutic strategies remains a major goal. Deregulation of c-MYC is evident in numer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6876b3be6926450ad1dd12ea1060409
https://doi.org/10.5167/uzh-28400