Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Cell Proliferation/drug effects"'
Publikováno v:
Acta Clinica Croatica, Vol 56., Iss 1., Pp 48-57 (2017)
Glioblastoma multiforme (GBM) is caused by the central nervous system-derived glial cells, and represents the most common (50%-60%) form of primary brain tumors. The aim of this study was to investigate the in vitro effects of selenium on human GBM c
Externí odkaz:
https://doaj.org/article/fba9229df3194b42b9f0d0bb2f6756e8
Autor:
Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron
Publikováno v:
PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)
PLoS ONE, Vol 17, Iss 2 (2022)
BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in
Autor:
Nikola Sobočan, Marta Himelreich-Perić, Ana Katušić-Bojanac, Jure Krasić, Nino Sinčić, Željka Majić, Gordana Jurić-Lekić, Ljiljana Šerman, Andreja Marić, Davor Ježek, Floriana Bulić-Jakuš
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 603
International Journal of Molecular Sciences, Vol 23, Iss 603, p 603 (2022)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 603, p 603 (2022)
International Journal of Molecular Sciences
Antioxidant N-tert-Butyl-α-phenylnitron (PBN) partly protected embryos from the negative effects of a DNA demethylating drug 5-azacytidine during pregnancy. Our aim was to investigate PBN’s impact on the placenta. Fischer rat dams were treated on
Autor:
Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton
Publikováno v:
Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373
SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf
Autor:
Marina Ivanišević, Heidi Miedl, Ursula Weiss-Fuchs, Désirée Forstner, Gernot Desoye, Djelmis J, Julia Bandres-Meriz, Ursula Hiden, Denise Hoch, Alejandro Majali-Martinez, Martin Gauster
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10989, p 10989 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy, but a contributing role of the placenta has remained elusive. Thus, we investigated whether T1DM alters placental development in the first trimester. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b45fcbea321d46b42ca47bb60f0114
https://doi.org/10.3390/ijms222010989
https://doi.org/10.3390/ijms222010989
Autor:
Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf
Publikováno v:
Nature communications, vol. 12, no. 1, pp. 5577
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2422edb39fce227889a8f8c1af0c166
https://www.repository.cam.ac.uk/handle/1810/328381
https://www.repository.cam.ac.uk/handle/1810/328381
Autor:
Martinez Sanz, Paula, van Rees, Dieke J, van Zogchel, Lieke M J, Klein, Bart, Bouti, Panagiota, Olsman, Hugo, Schornagel, Karin, Kok, Ivana, Sunak, Ali, Leeuwenburg, Kira, Timmerman, Ilse, Dierselhuis, Miranda P, Kholosy, Waleed M, Molenaar, Jan J, van Bruggen, Robin, van den Berg, Timo K, Kuijpers, Taco W, Matlung, Hanke L, Tytgat, Godelieve A M, Franke, Katka, Afd Pharmaceutics, Pharmaceutics
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central
Journal for immunotherapy of cancer, 9(5):e002259. BioMed Central Ltd.
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 9(5), 1. BioMed Central
Journal for immunotherapy of cancer, 9(5):e002259. BioMed Central Ltd.
BackgroundCurrent immunotherapy for patients with high-risk neuroblastoma involves the therapeutic antibody dinutuximab that targets GD2, a ganglioside expressed on the majority of neuroblastoma tumors. Opsonized tumor cells are killed through antibo
Autor:
Muriel Cuendet, Laila El Bouzidi, Philippe Christen, Jean-Marc Nuzillard, Widad Ben Bakrim, Khalid Bekkouche, Sylvian Cretton, Aymeric Monteillier, Noémie Saraux
Publikováno v:
Pharmaceutical Biology
Pharmaceutical Biology, Taylor & Francis, 2018, 56 (1), pp.505-510. ⟨10.1080/13880209.2018.1499781⟩
Pharmaceutical Biology, Vol 56, Iss 1, Pp 505-510 (2018)
Pharmaceutical Biology, Vol. 56, No 1 (2018) pp. 505-510
Pharmaceutical Biology, Taylor & Francis, 2018, 56 (1), pp.505-510. ⟨10.1080/13880209.2018.1499781⟩
Pharmaceutical Biology, Vol 56, Iss 1, Pp 505-510 (2018)
Pharmaceutical Biology, Vol. 56, No 1 (2018) pp. 505-510
Context:Withania (Solanaceae) species are known to be a rich source of withanolides, which have shown several biological properties. Objective: To identify the compounds responsible for Withania adpressa Coss. antioxidant activity and further test th
Autor:
Zaineb Abdelkafi-Koubaa, Mohamed El Ayeb, Erij Messadi, Najet Srairi Abid, Maram Morjen, Jed Jebali, Houcemeddine Othman, José Luis, Naziha Marrakchi
Publikováno v:
International Journal of Biological Macromolecules
International Journal of Biological Macromolecules, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International Journal of Biological Macromolecules, Elsevier, 2018, 117, pp.790-799. ⟨10.1016/j.ijbiomac.2018.05.230⟩
International audience; Through the recent development of knowledge in biotechnology and bioinformatics, snake venoms are widely used to develop new drugs to treat diseases such as hypertension and cancer. We have previously reported that Lebetin 2 i
Autor:
Jean-Luc Wolfender, Constant Anatole Pieme, Vladimir L. Katanaev, Tatiana V. Petrova, Artem Blagodatski, Emerson Ferreira Queiroz, Kamal Ahmed, Alexey Koval, Simone Ragusa
Publikováno v:
Cancer Letters, Vol. 435 (2018) pp. 110-120
Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required