BMP7 increases protein synthesis in SW1353 cells and determines rRNA levels in a NKX3-2-dependent manner

Autor: Ellen G. J. Ripmeester, Tim J. M. Welting, Guus G. H. van den Akker, Don A. M. Surtel, Jessica S. J. Steijns, Andy Cremers, Lodewijk W. van Rhijn, Marjolein M. J. Caron

Publikováno v: PLOS ONE, 17(2):e0263430. Public Library of Science
PLoS ONE, Vol 17, Iss 2 (2022)

BMP7 is a morphogen capable of counteracting the OA chondrocyte hypertrophic phenotype via NKX3-2. NKX3-2 represses expression of RUNX2, an important transcription factor for chondrocyte hypertrophy. Since RUNX2 has previously been described as an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b91411d9a3772f259276cff0fffa8e
https://doi.org/10.1371/journal.pone.0263430

Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors

Autor: Henry Beetham, Billie G.C. Griffith, Olga Murina, Alexander E.P. Loftus, David A. Parry, Carolin Temps, Jayne Culley, Morwenna Muir, Asier Unciti-Broceta, Andrew H. Sims, Adam Byron, Valerie G. Brunton

Publikováno v: Beetham, H, Griffith, B, Murina, O, Loftus, A, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2021, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research . https://doi.org/10.1158/0008-5472.CAN-21-0373
Beetham, H, Griffith, B G C, Murina, O, Loftus, A E P, Parry, D A, Temps, C, Culley, J, Muir, M, Unciti-Broceta, A, Sims, A H, Byron, A & Brunton, V G 2022, ' Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors ', Cancer Research, vol. 82, no. 4, pp. 632-647 . https://doi.org/10.1158/0008-5472.CAN-21-0373

SRC is a nonreceptor tyrosine kinase with key roles in breast cancer development and progression. Despite this, SRC tyrosine kinase inhibitors have so far failed to live up to their promise in clinical trials, with poor overall response rates. We aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60490b72d4b6e9896c2cb3f20e716f6
https://www.pure.ed.ac.uk/ws/files/245549967/Loss_of_Integrin_linked_kinase_sensitizes_breast_cancer_to_SRC_inhibitors_published_AAM.pdf

Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma

Autor: Liang, Huan-Chang, Costanza, Mariantonia, Prutsch, Nicole, Zimmerman, Mark W., Gurnhofer, Elisabeth, Montes-Mojarro, Ivonne A., Abraham, Brian J., Prokoph, Nina, Stoiber, Stefan, Tangermann, Simone, Lobello, Cosimo, Oppelt, Jan, Anagnostopoulos, Ioannis, Hielscher, Thomas, Pervez, Shahid, Klapper, Wolfram, Zammarchi, Francesca, Silva, Daniel-Adriano, Garcia, K. Christopher, Baker, David, Janz, Martin, Schleussner, Nikolai, Fend, Falko, Pospíšilová, Šárka, Janiková, Andrea, Wallwitz, Jacqueline, Stoiber, Dagmar, Simonitsch-Klupp, Ingrid, Cerroni, Lorenzo, Pileri, Stefano, de Leval, Laurence, Sibon, David, Fataccioli, Virginie, Gaulard, Philippe, Assaf, Chalid, Knörr, Fabian, Damm-Welk, Christine, Woessmann, Wilhelm, Turner, Suzanne D., Look, A. Thomas, Mathas, Stephan, Kenner, Lukas, Merkel, Olaf

Publikováno v: Nature communications, vol. 12, no. 1, pp. 5577
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Anaplastic large cell lymphoma (ALCL), an aggressive CD30-positive T-cell lymphoma, comprises systemic anaplastic lymphoma kinase (ALK)-positive, and ALK-negative, primary cutaneous and breast implant-associated ALCL. Prognosis of some ALCL subgroups

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2422edb39fce227889a8f8c1af0c166
https://www.repository.cam.ac.uk/handle/1810/328381

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Autor: Georges Khoury, Ashanti Dantanarayana, Rachel D. Pascoe, Ajantha Rhodes, Steven G. Deeks, Damian F. J. Purcell, Jenny L. Anderson, Matthew J. Gartner, Wei Zhao, Michael Roche, Megan Gooey, James H McMahon, Peter Bacchetti, Thomas A Rasmussen, Sharon R Lewin, Jennifer M. Zerbato

Publikováno v: Zerbato, J M, Khoury, G, Zhao, W, Gartner, M J, Pascoe, R D, Rhodes, A, Dantanarayana, A, Gooey, M, Anderson, J, Bacchetti, P, Deeks, S G, McMahon, J, Roche, M, Rasmussen, T A, Purcell, D F & Lewin, S R 2021, ' Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency ', EBioMedicine, vol. 65, pp. 103241 . https://doi.org/10.1016/j.ebiom.2021.103241
EBioMedicine, Vol 65, Iss, Pp 103241-(2021)

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent HIV infection with a latency reversing agent (LRA). Surrogate markers that acc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae31826809e96aa84f2539d37aa4714b
https://pure.au.dk/portal/da/publications/multiply-spliced-hiv-rna-is-a-predictive-measure-of-virus-production-ex-vivo-and-in-vivo-following-reversal-of-hiv-latency(df1ec419-f4f9-4dd7-85af-69b7d90a4d8a).html

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth

Autor: Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Brückner, Vladimir L. Katanaev, Jürgen Behrens, Dominic B. Bernkopf

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nature communications, Vol. 13, No 1 (2022) P. 674

Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe885a2c8672e90aca452bf1e54608d6
https://pubmed.ncbi.nlm.nih.gov/35115535