New insights into alterations in pl proteins affecting their binding to dna after exposure of mytilus galloprovincialis to mercury—a possible risk to sperm chromatin structure?

Autor: Antonella Giarra, Caterina Manna, Rosaria Notariale, Marco Trifuoggi, Marina Piscopo, Nadia Carusone, Gennaro Lettieri

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5893, p 5893 (2021)

Mercury (Hg) is a highly toxic and widespread pollutant. We previously reported that the exposure of Mytilus galloprovincialis for 24 h to doses of HgCl2 similar to those found in seawater (range 1–100 pM) produced alterations in the properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974dd6ddd6eff0bce83b6c47e0d7752c
http://hdl.handle.net/11588/854822

Mechanotransduction, nuclear architecture and epigenetics in Emery Dreifuss Muscular Dystrophy: tous pour un, un pour tous

Autor: Chiara Lanzuolo, Andrea Bianchi, Federica Lucini, Pierluigi Giuseppe Manti

Publikováno v: Nucleus

The alteration of the several roles that Lamin A/C plays in the mammalian cell leads to a broad spectrum of pathologies that – all together – are named laminopathies. Among those, the Emery Dreifuss Muscular Dystrophy (EDMD) is of particular inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbfa9991f51b3b96177c1ce8b75796c
http://europepmc.org/articles/PMC5973142

A Beckwith–Wiedemann-Associated CDKN1C Mutation Allows the Identification of a Novel Nuclear Localization Signal in Human p57Kip2

Autor: Adriana Borriello, Emanuela Stampone, Debora Bencivenga, Clementina Barone, Fulvio Della Ragione, Marilena Di Finizio

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7428, p 7428 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14

p57Kip2 protein is a member of the CIP/Kip family, mainly localized in the nucleus where it exerts its Cyclin/CDKs inhibitory function. In addition, the protein plays key roles in embryogenesis, differentiation, and carcinogenesis depending on its ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3215ca63354a26bd0341389a9f34062a
https://doi.org/10.3390/ijms22147428

The centrosomal/basal body protein OFD1 is required for microtubule organization and cell cycle progression

Autor: Gaetano Calì, Gerard W. Dougherty, Lucio Nitsch, Lucia Perone, Brunella Franco, Daniela Iaconis, Roberta Tammaro, Antonella Ragnini-Wilson, Mariaevelina Alfieri

Publikováno v: Tissuecell. 64

Oral-Facial-Digital type I (OFD1) is a rare inherited form of renal cystic disease associated with ciliary dysfunction. This disorder is due to mutations in the OFD1 gene that encodes a protein localized to centrosomes and basal bodies in different c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49ac0aadeddf7d53e793f7d4d948f51
https://pubmed.ncbi.nlm.nih.gov/32473706

Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage

Autor: Roberta Fiume, Irene Faenza, Antonio Enrico Zaurito, Nullin Divecha, Shidqiyyah Abdul-Hamid, Alessandro Poli

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2080 (2019)

Phosphatidylinositol (PI)-related signaling plays a pivotal role in many cellular aspects, including survival, cell proliferation, differentiation, DNA damage, and trafficking. PI is the core of a network of proteins represented by kinases, phosphata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbc30bbd19d2f9c831503be9cf4a0a2
http://europepmc.org/articles/PMC6539119