Bench to Bedside Development of [18F]Fluoromethyl-(1,2-2H4)choline ([18F]D4-FCH)

Autor: Amarnath Challapalli, Tara D. Barwick, Suraiya R. Dubash, Marianna Inglese, Matthew Grech-Sollars, Kasia Kozlowski, Henry Tam, Neva H. Patel, Mathias Winkler, Penny Flohr, Azeem Saleem, Amit Bahl, Alison Falconer, Johann S. De Bono, Eric O. Aboagye, Stephen Mangar

Publikováno v: Molecules, Vol 28, Iss 24, p 8018 (2023)

Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imagin

Externí odkaz: https://doaj.org/article/74674289d27f44588c3184f2bea4b18b

Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis

Autor: Henriette Rübsam, Christina Krönauer, Nikolaj B. Abel, Hongtao Ji, Damiano Lironi, Simon B. Hansen, Marcin Nadzieja, Marie V. Kolte, Dörte Abel, Noor de Jong, Lene H. Madsen, Huijun Liu, Jens Stougaard, Simona Radutoiu, Kasper R. Andersen

Publikováno v: Rübsam, H, Krönauer, C, Abel, N B, Ji, H, Lironi, D, Hansen, S B, Nadzieja, M, Kolte, M V, Abel, D, de Jong, N, Madsen, L H, Liu, H, Stougaard, J, Radutoiu, S & Andersen, K R 2023, ' Nanobody-driven signaling reveals the core receptor complex in root nodule symbiosis ', Science (New York, N.Y.), vol. 379, no. 6629, pp. 272-277 . https://doi.org/10.1126/science.ade9204

Understanding the composition and activation of multicomponent receptor complexes is a challenge in biology. To address this, we developed a synthetic approach based on nanobodies to drive assembly and activation of cell surface receptors and apply t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8cf4dbe9b3a3b603a7f52033825f0
https://doi.org/10.1126/science.ade9204

Functional amyloid in a lipid-like environment: a merry dance of many steps

Autor: Daniel Otzen

Publikováno v: Otzen, D E 2022, ' Functional amyloid in a lipid-like environment : a merry dance of many steps ', Essays in Biochemistry, vol. 66, no. 7 . https://doi.org/10.1042/EBC20220062

Functional amyloid, which unlike its pathological counterpart serves a biological purpose, is produced in a carefully orchestrated sequence of events. In bacteria, the major amyloid component is transported over the periplasm and through the outer me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba106d4448d4b0d6b675881aea2b90
https://doi.org/10.1042/ebc20220062

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

Autor: Amit Kumar, Oscar Vadas, Nicolas Dos Santos Pacheco, Xu Zhang, Kin Chao, Nicolas Darvill, Helena Ø Rasmussen, Yingqi Xu, Gloria Meng-Hsuan Lin, Fisentzos A Stylianou, Jan Skov Pedersen, Sarah L Rouse, Marc L Morgan, Dominique Soldati-Favre, Stephen Matthews

Publikováno v: Kumar, A, Vadas, O, Dos Santos Pacheco, N, Zhang, X, Chao, K, Darvill, N, Rasmussen, H Ø, Xu, Y, Lin, G M-H, Stylianou, F A, Pedersen, J S, Rouse, S L, Morgan, M L, Soldati-Favre, D & Matthews, S 2023, ' Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii ', eLife, vol. 12 . https://doi.org/10.7554/eLife.86049

The phylum of Apicomplexa groups intracellular parasites that employ substrate-dependent gliding motility to invade host cells, egress from the infected cells, and cross biological barriers. The glideosome-associated connector (GAC) is a conserved pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bcdeb04e5a4e623d5f3af8c20553026
https://pure.au.dk/portal/da/publications/structural-and-regulatory-insights-into-the-glideosomeassociated-connector-from-toxoplasma-gondii(882484a3-51a4-4027-b7cc-e5abd3338998).html

Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides

Autor: Marc Serulla, Palapuravan Anees, Ali Hallaj, Evgeniya Trofimenko, Tara Kalia, Yamuna Krishnan, Christian Widmann

Publikováno v: European journal of pharmaceutics and biopharmaceutics, vol. 184, pp. 116-124

Cell-penetrating peptides (CPPs) are short (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52827b3735c700165921431aca0a2126
https://serval.unil.ch/notice/serval:BIB_7AEBB57EE86D