Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Cell Membrane/drug effects"'
Autor:
Shukla, Rhythm, Lavore, Francesca, Maity, Sourav, Derks, Maik G.N., Jones, Chelsea R., Vermeulen, Bram J.A., Melcrová, Adéla, Morris, Michael A., Becker, Lea Marie, Wang, Xiaoqi, Kumar, Raj, Medeiros-Silva, João, van Beekveld, Roy A.M., Bonvin, Alexandre M.J.J., Lorent, Joseph H., Lelli, Moreno, Nowick, James S., MacGillavry, Harold D., Peoples, Aaron J., Spoering, Amy L., Ling, Losee L., Hughes, Dallas E., Roos, Wouter H., Breukink, Eefjan, Lewis, Kim, Weingarth, Markus, Sub NMR Spectroscopy, Sub Membrane Biochemistry & Biophysics, Sub Cell Biology, NMR Spectroscopy, Celbiologie, Membrane Biochemistry and Biophysics
Publikováno v:
Nature, 608(7922), 390. Nature Research
Nature
Nature, 608(7922), 390-396. Nature Publishing Group
Nature
Nature, 608(7922), 390-396. Nature Publishing Group
Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance1–3. Teixobactin4 represents a new class of antibiotics with a unique chemical scaffold and lack of detectable resistance. Teixobactin targets lipid II, a precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a758c21eadc4b4daf2806d5db5df77
https://doi.org/10.1038/s41586-022-05019-y
https://doi.org/10.1038/s41586-022-05019-y
Autor:
Matthew S. P. Boyles, Martin Himly, Ulrike Tischler, Jiayuan Zhao, Eva Hornig, Víctor F. Puntes, Michael Riediker, Albert Duschl, Eudald Casals, Gertie Janneke Oostingh, Paul Schlinkert, Ngoc Tran
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Nanobiotechnology
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Journal of Nanobiotechnology, vol. 13, no. 1, pp. 1
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Journal of Nanobiotechnology
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Journal of Nanobiotechnology, vol. 13, no. 1, pp. 1
Background Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1697bc84770ff9922a3f96e3998c32
http://hdl.handle.net/2072/435898
http://hdl.handle.net/2072/435898
Autor:
Stéphane Baeriswyl, Sacha Javor, Christian van Delden, Ivan Di Bonaventura, Giovanni Di Bonaventura, Thissa N. Siriwardena, Jean-Louis Reymond, Alice Capecchi, Arianna Pompilio, Xian Jin, Thilo Köhler, Runze He, Bee Ha Gan
Publikováno v:
Chemical Communications, Vol. 54, No 40 (2018) pp. 5130-5133
We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0b4aac96c748dbde6321aa6ef5f831
https://doi.org/10.1039/c8cc02412j
https://doi.org/10.1039/c8cc02412j
Autor:
Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012
Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e45c56c9b3fcde327e5251318035d4
https://escholarship.org/uc/item/0388t0qm
https://escholarship.org/uc/item/0388t0qm
Autor:
Aakash Patel, Hala Guedouari, Elzbieta Janda, Karine Reybier, Istvan Gacsalyi, Vishalgiri Goswami, Jean A. Boutin, Adeline Giganti, Mathias Antoine, Monivan Chhour, Marie-Claude Viaud-Massuard, Hervé Da Costa, Marc Bertrand, Pierre Ducrot, Jérôme Paysant, Patrick P. Michel, Gilles Ferry, Thierry Le Diguarher, Daniel A. Kane, Françoise Nepveu, Frédéric Bouillaud, Karen Brebner, Gérald Guillaumet, Etienne C. Hirsch, Philippe Dupuis, Johann Stojko
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
Molecular Pharmacology, 2019, 95 (3), pp.269-285. ⟨10.1124/mol.118.114231⟩
International audience; Quinone reductase 2 (QR2, E.C. 1.10.5.1) is an enzyme with a feature that has attracted attention for several decades: in standard conditions, instead of recognizing NAD(P)H as an electron donor, it recognizes putative metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c332ae7dd4579c5014783569d4574301
https://www.hal.inserm.fr/inserm-02334766
https://www.hal.inserm.fr/inserm-02334766
Publikováno v:
Royal, A A, Tinker, A & Harmer, S C 2017, ' Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking ', PLoS ONE, vol. 12, no. 10, e0186293 . https://doi.org/10.1371/journal.pone.0186293
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186293 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186293 (2017)
The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9934a78462ca46553876bde14dd757dd
https://research-information.bris.ac.uk/en/publications/e514aac4-3f9f-4fe8-bf0c-8fe083982c1b
https://research-information.bris.ac.uk/en/publications/e514aac4-3f9f-4fe8-bf0c-8fe083982c1b
Autor:
James R. Sellers, Francisco Mesquita, Cláudia Brito, Christopher K. E. Bleck, Didier Cabanes, Sandra Maria Zákia Lian Sousa
Publikováno v:
Toxins
Toxins, Vol 11, Iss 7, p 419 (2019)
Volume 11
Issue 7
Toxins, Vol 11, Iss 7, p 419 (2019)
Volume 11
Issue 7
Clostridium perfringens produces an arsenal of toxins that act together to cause severe infections in humans and livestock animals. Perfringolysin O (PFO) is a cholesterol-dependent pore-forming toxin encoded in the chromosome of virtually all C. per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501bbe193609018b897d54a8602ff834
https://doi.org/10.3390/toxins11070419
https://doi.org/10.3390/toxins11070419
Autor:
Nils J. Færgeman, Xun Shi, Jennifer L. Watts, Juan Li, Joel Greggain, Bin Liang, Steven Vestergaard Rødkær, Xiaoju Zou
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2504-2514 (2013)
Journal of Lipid Research
Shi, X, Li, J, Zou, X, Greggain, J, Rodkaer, S V, Færgeman, N J, Liang, B & Watts, J L 2013, ' Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase ', Journal of Lipid Research, vol. 54, pp. 2504-2514 . https://doi.org/10.1194/jlr.M039669
Journal of Lipid Research
Shi, X, Li, J, Zou, X, Greggain, J, Rodkaer, S V, Færgeman, N J, Liang, B & Watts, J L 2013, ' Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase ', Journal of Lipid Research, vol. 54, pp. 2504-2514 . https://doi.org/10.1194/jlr.M039669
Fatty acid desaturation regulates membrane function and fat storage in animals. To determine the contribution of stearoyl-CoA desaturase (SCD) activity on fat storage and development in the nematode Caenorhabditis elegans , we analyzed the lipid comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0050fc0b77717ead80576110da07e95e
http://www.sciencedirect.com/science/article/pii/S0022227520351397
http://www.sciencedirect.com/science/article/pii/S0022227520351397
Autor:
Rosane Souza da Silva, Fabiano Peres Menezes, Luiza Reali Nazario, Luiza Wilges Kist, Lidiane Fazenda, Angela T. S. Wyse, Maurício Reis Bogo, Katiucia Marques Capiotti, Carla Denise Bonan
Publikováno v:
International Journal of Developmental Neuroscience, 31(1), 75-81. Elsevier-Pergamon
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Hyperargininemia is an inborn error of metabolism (IEM) characterized by tissue accumulation of arginine (Arg). Mental retardation and other neurological features are common symptoms in hyperargininemic patients. Considering purinergic signaling has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1cfc77c633b088e799ced9b6836732
https://doi.org/10.1016/j.ijdevneu.2012.09.002
https://doi.org/10.1016/j.ijdevneu.2012.09.002
Autor:
Thomas P. Davis, William J Stanley, Emily H. Pilkington, Aleksandr Kakinen, Pu Chun Ke, Esteban Nicolas Gurzov, Sara A Litwak
Publikováno v:
Scientific Reports
Scientific reports, 6
Scientific reports, 6
Aggregation of human islet amyloid polypeptide (hIAPP) into fibrils and plaques is associated with pancreatic β-cell loss in type 2 diabetes (T2D). However, due to the rapidness of hIAPP conversion in aqueous phase, exactly which hIAPP species is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c50dc79658d06ec54dbc479241eab4
https://doi.org/10.1038/srep21274
https://doi.org/10.1038/srep21274