Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Cell Homeostasis & Autophagy"'
Publikováno v:
Clinical Science (London, England : 1979)
Pulmonary hypertension (PH) is a life-threatening disease characterized by vascular remodeling. Exploring new therapy target is urgent. The purpose of the present study is to investigate whether and how spliced x-box binding protein 1 (xbp1s), a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3e0473ba88f1d03d1774d11b3ea94d
https://doi.org/10.1042/cs20211095
https://doi.org/10.1042/cs20211095
Autor:
Jeff W. Barclay, Claire E. Eyers, Alan Morgan, Kimberley Burrow, Richard Campion, Patricia Thomas, Philip Brownridge, Leanne Bloxam, Campbell W. Gourlay, Daniel R Pentland
Publikováno v:
Biochemical Journal
BIOCHEMICAL JOURNAL
BIOCHEMICAL JOURNAL
Dietary restriction (DR) has been shown to increase lifespan in organisms ranging from yeast to mammals. This suggests that the underlying mechanisms may be evolutionarily conserved. Indeed, upstream signalling pathways, such as TOR, are strongly lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001c2b957e65bce57d990b8e60397836
http://europepmc.org/articles/PMC8786290
http://europepmc.org/articles/PMC8786290
Publikováno v:
Essays in Biochemistry
To date, mechanistic treatments targeting the initial cause of Parkinson's disease (PD) are limited due to the underlying biological cause(s) been unclear. Endosomes and their associated cellular homeostasis processes have emerged to have a significa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a462cb7e4e7c66dd7778e4bbff42ab
https://doi.org/10.1042/ebc20210023
https://doi.org/10.1042/ebc20210023
Publikováno v:
Essays in Biochemistry
PTEN-induced kinase 1 (PINK1) impacts cell health and human pathology through diverse pathways. The strict processing of full-length PINK1 on the outer mitochondrial membrane populates a cytoplasmic pool of cleaved PINK1 (cPINK1) that is constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c94d73c94e30d403438284e9f53a1f
https://doi.org/10.1042/ebc20210036
https://doi.org/10.1042/ebc20210036
Autor:
Pamela J. Shaw, Nikita Soni, Tobias Moll, Jack N G Marshall, Sai Zhang, Johnathan Cooper-Knock
Publikováno v:
Essays in Biochemistry
Age-associated neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD) are an unmet health need, with significant economic and societal implications, and an ever-increasing prevale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49361db2d358a3bd30db78085a64e0a
https://doi.org/10.1042/ebc20210026
https://doi.org/10.1042/ebc20210026
Autor:
Jiwon Park, Carsten G. Hansen
Publikováno v:
Biochemical Society Transactions
Park, J & Hansen, C G 2021, ' Cellular feedback dynamics and multilevel regulation driven by the hippo pathway ', Biochemical Society Transactions, vol. 49, no. 4, pp. 1515-1527 . https://doi.org/10.1042/BST20200253
Park, J & Hansen, C G 2021, ' Cellular feedback dynamics and multilevel regulation driven by the hippo pathway ', Biochemical Society Transactions, vol. 49, no. 4, pp. 1515-1527 . https://doi.org/10.1042/BST20200253
The Hippo pathway is a dynamic cellular signalling nexus that regulates differentiation and controls cell proliferation and death. If the Hippo pathway is not precisely regulated, the functionality of the upstream kinase module is impaired, which inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c062d919c2202bfdecfc3c8b5ba88a
http://europepmc.org/articles/PMC8421037
http://europepmc.org/articles/PMC8421037
Autor:
François Singh, Ian G. Ganley
Publikováno v:
Biochemical Society Transactions
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects around 2% of individuals over 60 years old. It is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, which is thou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a680569216d3da193ee279b0867bdd6b
https://doi.org/10.1042/bst20190236
https://doi.org/10.1042/bst20190236
Publikováno v:
Biochemical Society Transactions
The accumulation of misfolded proteins is associated with numerous degenerative conditions, cancers and genetic diseases. These pathological imbalances in protein homeostasis (termed proteostasis), result from the improper triage and disposal of dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c47cb5f3e24aee7d26054ba57934a1
http://europepmc.org/articles/PMC7924994
http://europepmc.org/articles/PMC7924994
Autor:
Itay Koren, Richard T. Timms
Publikováno v:
Biochemical Society Transactions
Selective protein degradation by the ubiquitin-proteasome system (UPS) is thought to be governed primarily by the recognition of specific motifs — degrons — present in substrate proteins. The ends of proteins — the N- and C-termini – have uni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70dbfd045d71defcd782204b04305be
https://doi.org/10.1042/bst20191094
https://doi.org/10.1042/bst20191094
Autor:
Qingzhang Zhu
Publikováno v:
Clinical Science (London, England : 1979)
Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256e448ebd24275c3113d7bbc9c1e081
https://doi.org/10.1042/cs20200235
https://doi.org/10.1042/cs20200235