Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

Autor: George S. Vassiliou, Eytan M. Stein, Cyril Quivoron, Ross L. Levine, Lynn Quek, Stéphane de Botton, Paresh Vyas, Bilyana Stoilova, Michael Amatangelo, Alison Kennedy, M. S. Vijayabaskar, Alan Shih, O. Bernard, Virginie Penard-Lacronique, Katharine E. Yen, Véronique Saada, Maël Heiblig, Samar Alsafadi, Marlen Metzner, Kyle J. MacBeth, Muriel D. David, Andy Peniket, Anjan Thakurta, Sam Agresta, Christophe Willekens

Publikováno v: Quek, L, David, M D, Kennedy, A, Metzner, M, Amatangelo, M, Shih, A, Stoilova, B, Quivoron, C, Heiblig, M, Willekens, C, Saada, V, Alsafadi, S, Vijayabaskar, M S, Peniket, A, Bernard, O A, Agresta, S, Yen, K, MacBeth, K, Stein, E, Vassiliou, G S, Levine, R, De Botton, S, Thakurta, A, Penard-Lacronique, V & Vyas, P 2018, ' Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib ', Nature Medicine, vol. 24, no. 8, pp. 1167-1177 . https://doi.org/10.1038/s41591-018-0115-6

Mutations in the gene encoding isocitrate dehydrogenase 2 (IDH2) occur in several types of cancer, including acute myeloid leukemia (AML). In model systems, mutant IDH2 causes hematopoietic differentiation arrest. Enasidenib, a selective small-molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d30ad4500bdf6ee72adaf9de1577627
https://doi.org/10.1038/s41591-018-0115-6

Human Induced Pluripotent Stem Cell-Derived Definitive Endoderm Bulk Culture and Hepatic Differentiation

Autor: Palakkan, Anwar A, Nanda, Jyoti, Ross, James A

Publikováno v: Palakkan, A A, Nanda, J & Ross, J A 2019, ' Human Induced Pluripotent Stem Cell-Derived Definitive Endoderm Bulk Culture and Hepatic Differentiation ', Methods in molecular biology (Clifton, N.J.), vol. 1994, pp. 41-53 . https://doi.org/10.1007/978-1-4939-9477-9_4

We have developed a method to bulk culture definitive endoderm cells generated from human iPSCs which can be stored and differentiated to hepatocytes. Human iPSC-derived definitive endoderm cells were sorted based on the expression of CXCR4. The sort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::6022cb8e8f04d48b63d5cdb46e8e90c4
https://www.pure.ed.ac.uk/ws/files/242765790/Palakkan_180816_.docx

Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery: Converting Waste Materials into Biomaterials

Autor: Alireza Dolatshahi-Pirouz, Gorka Orive, Mohammad-Ali Shahbazi, Ashish Thakur, Akhilesh K. Gaharwar, Mehdi Mehrali, Malgorzata Karolina Pierchala, Julio Alvin Vacacela Cordova, Firoz Babu Kadumudi, Mohammad Mehrali, Cristian Pablo Pennisi

Publikováno v: Mehrali, M, Thakur, A, Kadumudi, F B, Pierchala, M K, Cordova, J A V, Shahbazi, M-A, Mehrali, M, Pennisi, C P, Orive, G, Gaharwar, A K & Dolatshahi-Pirouz, A 2019, ' Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery : Converting Waste Materials into Biomaterials ', ACS Applied Materials & Interfaces, vol. 11, no. 13, pp. 12283-12297 . https://doi.org/10.1021/acsami.9b00154
Acs Applied Materials & Interfaces., 11, 12283-12297
Acs Applied Materials & Interfaces., 11, 13, pp. 12283-12297
ACS applied materials & interfaces, 11(13), 12283-12297. American Chemical Society

The emergence of nontoxic, eco-friendly, and biocompatible polymers derived from natural sources has added a new and exciting dimension to the development of low-cost and scalable biomaterials for tissue engineering applications. Here, we have develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0594ee012ab100a75dc840529708cd2
https://pubmed.ncbi.nlm.nih.gov/30864429

Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis

Autor: Paul R. Thompson, Hidenari Takahara, Laura Cau, Guy Serre, Michel Simon, Marie-Claire Méchin

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (9), pp.1889-1897.e4. ⟨10.1016/j.jid.2019.02.026⟩
J Invest Dermatol

International audience; Deimination, a post-translational modification catalyzed by a family of enzymes called peptidylarginine deiminases (PADs), is the conversion of arginine into citrulline residues in a protein. Deimination has been associated wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f9749a5b19b13328a286eb478c2584
https://ut3-toulouseinp.hal.science/hal-03156447/document

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells

Autor: Halsey Christina, Docherty Marie, McNeill Mhairi, Gilchrist Derek, Le Brocq Michelle, Gibson Brenda, Graham Gerard

Publikováno v: Journal of Hematology & Oncology, Vol 5, Iss 1, p 45 (2012)

Abstract Background Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly

Externí odkaz: https://doaj.org/article/756f2504bf1d4459aae3787011aa915c