Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Cell Death/physiology"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1008912 (2020)
PLoS Genetics
PLoS Genetics
The mechanism(s) through which mammalian kinase MELK promotes tumorigenesis is not understood. We find that theC. elegansorthologue of MELK, PIG-1, promotes apoptosis by partitioning an anti-apoptotic factor. TheC. elegansNSM neuroblast divides to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e89eb8b227c8d8bb6fd9f36c74a4f95
https://doi.org/10.1101/2020.06.04.133983
https://doi.org/10.1101/2020.06.04.133983
Autor:
Pierre-Emmanuel Rautou, Jihoon Nah, Junichi Sadoshima, Anwu Zhou, Yang Liu, Álvaro F. Fernández, Marion Tanguy, Beth Levine, Ming Chang Hu, Bruce A. Posner, Vanessa Ginet, Guanghua Xiao, Mingjun Shi, Julien Puyal, Valérie Paradis, Zhongju Zou
Publikováno v:
JCI insight, vol. 5, no. 1, pp. e133282
Autosis is a distinct form of cell death that requires both autophagy genes and the Na+,K+-ATPase pump. However, the relationship between the autophagy machinery and Na+,K+-ATPase is unknown. We explored the hypothesis that Na+,K+-ATPase interacts wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e283a34ec502b8fce3946670aad20b5
Autor:
Claudiane Guay, Cécile Jacovetti, Olivier Dumortier, Romano Regazzi, Marc Prentki, Kailun Lee, Clara Sanchez-Parra, D. Ross Laybutt, Marie Line Peyot, Emmanuel Van Obberghen
Publikováno v:
Diabetes, vol. 67, no. 11, pp. 2254-2267
Pancreatic β-cell expansion throughout the neonatal period is essential to generate the appropriate mass of insulin-secreting cells required to maintain blood glucose homeostasis later in life. Hence, defects in this process can predispose to diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab24d0add4dee85f694fb22e0740401e
https://serval.unil.ch/notice/serval:BIB_FD9DD41BF15E
https://serval.unil.ch/notice/serval:BIB_FD9DD41BF15E
Autor:
David M. Suter, Jian-Ping Lu, Baoan Chen, Jiao Zhang, Qun Lu, Karl-Heinz Krause, M. Elizabeth Fini
Publikováno v:
Experimental Cell Research, Vol. 316, No 6 (2010) pp. 1070-1081
Pax6, a mammalian homolog of the Drosophila paired box gene family member expressed in stem and progenitor cells, resides at the top of the genetic hierarchy in controlling cell fates and morphogenesis. While Pax6 activation can lead to mitotic arres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746e2bfe113556d360b29297b79d1c3c
https://doi.org/10.1016/j.yexcr.2010.01.006
https://doi.org/10.1016/j.yexcr.2010.01.006
Publikováno v:
Annals of Neurology, vol. 66, no. 3, pp. 378-389
OBJECTIVE: To evaluate the contributions of autophagic, necrotic, and apoptotic cell death mechanisms after neonatal cerebral ischemia and hence define the most appropriate neuroprotective approach for postischemic therapy. METHODS: Rats were exposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c2427855a3b98cbcd2cc72a27c2a2b
https://doi.org/10.1002/ana.21714
https://doi.org/10.1002/ana.21714
Publikováno v:
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology, Nature Publishing Group, 2006, 7 (7), pp.517-28. ⟨10.1038/nrm1963⟩
Nature Reviews Molecular Cell Biology, Nature Publishing Group, 2006, 7, pp.517-28
Nature Reviews Molecular Cell Biology, Nature Publishing Group, 2006, 7 (7), pp.517-28. ⟨10.1038/nrm1963⟩
Nature Reviews Molecular Cell Biology, Nature Publishing Group, 2006, 7, pp.517-28
1471-0072 (Print) Journal Article Review; The addition to proteins of the negatively charged polymer of ADP-ribose (PAR), which is synthesized by PAR polymerases (PARPs) from NAD(+), is a unique post-translational modification. It regulates not only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c421c65481ba028613268a0c52f35d7
https://doi.org/10.1038/nrm1963
https://doi.org/10.1038/nrm1963
Autor:
Alexander G. Nikonenko, Irina Nikonenko, Dominique Muller, Galina Skibo, T Kovalenko, I. V. Lushnikova, Kirill Voronin, Irina Osadchenko
Publikováno v:
Hippocampus, Vol. 16, No 10 (2006) pp. 814-825
Relatively mild ischemic episode can initiate a chain of events resulting in delayed cell death and significant lesions in the affected brain regions. We studied early synaptic modifications after brief ischemia modeled in rats by transient vessels'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ddf2aac655b2911f29c298911d0814
https://doi.org/10.1002/hipo.20211
https://doi.org/10.1002/hipo.20211
Autor:
Valentina Chiusolo, Denis Martinvalet, Guillaume Jacquemin, Paul R. Walker, Esen Yonca Bassoy, Cristina Riccadonna
Publikováno v:
PLOS ONE, Vol. 11, No 4 (2016) P. e0153433
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0153433 (2016)
PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0153433 (2016)
Glioblastoma multiforme, the most aggressive primary brain tumor, is maintained by a subpopulation of glioma cells with self-renewal properties that are able to recapitulate the entire tumor even after surgical resection or chemo-radiotherapy. This t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4fe4904d75aab72a4cbc9d65e58d43
https://doi.org/10.1371/journal.pone.0153433
https://doi.org/10.1371/journal.pone.0153433
Publikováno v:
PLoS ONE
Plos One, vol. 6, no. 6, pp. e21586
PLoS ONE, Vol 6, Iss 6, p e21586 (2011)
Plos One, vol. 6, no. 6, pp. e21586
PLoS ONE, Vol 6, Iss 6, p e21586 (2011)
BACKGROUND: Glucose is the most important metabolic substrate of the retina and maintenance of normoglycemia is an essential challenge for diabetic patients. Glycemic excursions could lead to cardiovascular disease, nephropathy, neuropathy and retino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37936fa018e71c26c09b6c8f369b0153
http://europepmc.org/articles/PMC3124528
http://europepmc.org/articles/PMC3124528
Autor:
Scorrano, Luca
Publikováno v:
International Journal of Biochemistry & Cell Biology, Vol. 41, No 10 (2009) pp. 1875-1883
Mitochondria are key organelles in the regulation of apoptosis induced by intrinsic stimuli. This is accomplished by the release in the cytoplasm of cytochrome c and of other cofactors that ensure the activation of effector caspases. Multiple changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::a86b314c2f9e6d3db49fd7751b6048a6
https://archive-ouverte.unige.ch/unige:20096
https://archive-ouverte.unige.ch/unige:20096