Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Cell Death/drug effects"'
Publikováno v:
Acta Clinica Croatica, Vol 56., Iss 1., Pp 48-57 (2017)
Glioblastoma multiforme (GBM) is caused by the central nervous system-derived glial cells, and represents the most common (50%-60%) form of primary brain tumors. The aim of this study was to investigate the in vitro effects of selenium on human GBM c
Externí odkaz:
https://doaj.org/article/fba9229df3194b42b9f0d0bb2f6756e8
Autor:
Daniel Gonsales Spindola, Andre Hinsberger, Valéria Maria de Souza Antunes, Luis Felipe Gomes Michelin, Claudia Bincoletto, Carlos Rocha Oliveira
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018)
ABSTRACT Preservatives are widely used substances that are commonly added to various cosmetic and pharmaceutical products to prevent or inhibit microbial growth. In this study, we compared the in vitro cytotoxicity of different types of currently use
Externí odkaz:
https://doaj.org/article/9e288c8153344efd8721064e87583f22
Autor:
Biancamaria Farina, Carsten Culmsee, Amalia Mihaela Dolga, Luigi Russo, Menotti Ruvo, Nunzianna Doti, Roberto Fattorusso, Fabiola Mascanzoni, Alessandra Monti, Andrea Caporale
Publikováno v:
Journal of Medicinal Chemistry, 64(15), 11445-11459. AMER CHEMICAL SOC
Blocking the interaction between the apoptosis-inducing factor (AIF) and cyclophilin A (CypA) by the AIF fragment AIF(370-394) is protective against glutamate-induced neuronal cell death and brain injury in mice. Starting from AIF(370-394), we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8753f90236e54cb76eea53ccd197d5e8
https://research.rug.nl/en/publications/04f3e107-9064-406a-8ac0-abfc6105b17f
https://research.rug.nl/en/publications/04f3e107-9064-406a-8ac0-abfc6105b17f
Autor:
Liu, Peng, Zhao, Liwei, Pol, Jonathan, Levesque, Sarah, Petrazzuolo, Adriana, Pfirschke, Christina, Engblom, Camilla, Rickelt, Steffen, Yamazaki, Takahiro, Iribarren, Kristina, Senovilla, Laura, Bezu, Lucillia, Vacchelli, Erika, Sica, Valentina, Melis, Andréa, Martin, Tiffany, Lin, Xia, Yang, Heng, Li, Qingqing, Chen, Jinfeng, Durand, Sylvère, Aprahamian, Fanny, Lefevre, Deborah, Broutin, Sophie, Paci, Angelo, Bongers, Amaury, Minard-Colin, Veronique, Tartour, Eric, Zitvogel, Laurence, Apetoh, Lionel, Ma, Yuting, Pittet, Mikael J., Kepp, Oliver, Kroemer, Guido
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.1486. ⟨10.1038/s41467-019-09415-3⟩
Nature Communications, Vol. 10, No 1 (2019) P. 1486
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.1486. ⟨10.1038/s41467-019-09415-3⟩
Nature Communications, Vol. 10, No 1 (2019) P. 1486
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed0d8ca6cf5c1e35474efa37860411f6
http://link.springer.com/article/10.1038/s41467-019-09415-3
http://link.springer.com/article/10.1038/s41467-019-09415-3
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic slippage, due to premature mitotic exit. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65669c7d34d09c189b5e66595f1fe50
https://pubmed.ncbi.nlm.nih.gov/33603057
https://pubmed.ncbi.nlm.nih.gov/33603057
Autor:
Dan Ploug Christensen, Jakob Bondo Hansen, Thomas Mandrup-Poulsen, Seyed Mojtaba Ghiasi, Björn Tyrberg
Publikováno v:
International Journal of Molecular Sciences
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International journal of molecular sciences, vol. 21, no. 12 . https://doi.org/10.3390/ijms21124311
International Journal of Molecular Sciences, Vol 21, Iss 4311, p 4311 (2020)
Ghiasi, S M, Hansen, J B, Christensen, D P, Tyrberg, B & Mandrup-Poulsen, T 2020, ' The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets ', International Journal of Molecular Sciences (Online), vol. 21, no. 12, 4311 . https://doi.org/10.3390/ijms21124311
Volume 21
Issue 12
Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6abcd30245c0405a97103ff0148386
http://europepmc.org/articles/PMC7352593
http://europepmc.org/articles/PMC7352593
Autor:
Emre Guney, Mahmoud H. Elbatreek, Harald H.H.W. Schmidt, Jan Baumbach, Javier Egea, Simon J. Larsen, Vanessa Gómez-Rangel, Ana I. Casas, Pamela W. M. Kleikers, Manuela G. López, Ahmed A. Hassan
Publikováno v:
Casas, A I, Hassan, A A, Larsen, S J, Gomez-Rangel, V, Elbatreek, M, Kleikers, P W M, Guney, E, Egea, J, López, M G, Baumbach, J & Schmidt, H H H W 2019, ' From single drug targets to synergistic network pharmacology in ischemic stroke ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 14, pp. 7129-7136 . https://doi.org/10.1073/pnas.1820799116
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Current one drug–one target–one disease approaches in drug discovery have become increasingly inefficient. Network pharmacology defines disease mechanisms as networks best targeted by multiple, synergistic drugs. Using the high unmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bd3be0432e66a4fc3c69b16682fec9
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf
https://findresearcher.sdu.dk:8443/ws/files/151606865/From_single_drug_targets_to_synergistic_network_pharmacology_in_ischemic_stroke.pdf
Autor:
Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012
Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e45c56c9b3fcde327e5251318035d4
https://escholarship.org/uc/item/0388t0qm
https://escholarship.org/uc/item/0388t0qm
Autor:
Marc Ansari, Denis Marino, Vid Mlakar, John M. Maris, Simona Jurkovic Mlakar, Laurence Lesne, Komal S. Rathi, Fabienne Gumy-Pause
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol. 38, No 1 (2019) P. 69
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research, Vol. 38, No 1 (2019) P. 69
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Background Neuroblastoma is the most common extracranial solid tumor in children. This cancer has a low frequency of TP53 mutations and its downstream pathway is usually intact. This study assessed the efficacy of the p53 activator, PRIMA-1MET, in in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9c2429fecd6322f20a7b36628c56f3
http://europepmc.org/articles/PMC6373164
http://europepmc.org/articles/PMC6373164
Autor:
Andrej Babič, Hans-Paul Juretschke, Paolo Meda, Heiner Glombik, Nathalie Martine Stransky-Heilkron, Norbert Lange, Smaragda Lamprianou, Laurent Vinet, Celine Xayaphoummine, Anke M. Schulte, Marino A. Campo, Xavier Montet
Publikováno v:
Biomaterials
Biomaterials, Vol. 75 (2016) pp. 1-12
Biomaterials, Vol. 75 (2016) pp. 1-12
The monitoring of diabetes mellitus, as it develops and becomes clinically evident, remains a major challenge for diagnostic imaging in clinical practice. Here we present a novel approach to beta-cell imaging by targeting the sulphonylurea receptor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80ba5b71f1ca3601d0b0eaab90bae79
https://doi.org/10.1016/j.biomaterials.2015.10.006
https://doi.org/10.1016/j.biomaterials.2015.10.006