Výsledky vyhledávání - "Cell Cycle Checkpoints/drug effects/genetics"

Overexpression of the human antigen R suppresses the immediate paradoxical proliferation of melanoma cell subpopulations in response to suboptimal BRAF inhibition

Autor: Christoph Schwärzler, Sylvain Lemeille, Wolf-Henning Boehncke, Hedwig Sutterlüty-Fall, Marylise Fernandez, Rastine Merat

Publikováno v: Cancer Medicine, Vol. 6, No 7 (2017) pp. 1652-1664
Cancer Medicine

Tumor plasticity and the heterogeneous response of melanoma cells to targeted therapies are major limits for the long‐term efficacy of this line of therapy. Targeting tumor plasticity is theoretically possible through the modulation of the expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39db6c1f4fd5a65b4195357047cb1e95
https://archive-ouverte.unige.ch/unige:106964

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Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional

Autor: G Lossaint, Emilie Besnard, Daniel Fisher, Jacques Piette, Vjekoslav Dulic

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2011, 30 (41), pp.4261--74. ⟨10.1038/onc.2011.135⟩

In the presence of sustained DNA damage occurring in S-phase or G2, normal cells arrest before mitosis and eventually become senescent. The checkpoint kinases Chk1/Chk2 and the CDK inhibitor p21 are known to have important complementary roles in this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d676aed23cbb7b053282ee72b12f2b
https://hal.archives-ouvertes.fr/hal-02193324

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