SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation

Autor: Linh Le, Elena V. Sviderskaya, Ariel J Lefkovith, Emily Latteri, Elena Oancea, Michael S. Marks, Kirk D. Haltaufderhyde, Megan K Dennis, Iliana E. Escobar, Tina Ho, Dorothy C. Bennett, Lynn Plowright

Publikováno v: Molecular Biology of the Cell

SLC45A2 encodes a putative transporter expressed primarily in pigment cells. SLC45A2 mutations cause oculocutaneous albinism type 4 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function, and regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0cae089f8c3c71a2747668a8d619ad
https://doi.org/10.1091/mbc.e20-03-0200

XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome

Autor: Jae-Sook Park, Aaron M. Neiman

Publikováno v: Molecular Biology of the Cell

Vps13 is a highly conserved lipid transfer protein found at multiple interorganelle membrane contact sites where it mediates distinct processes. In yeast, recruitment of Vps13 to different contact sites occurs via various partner proteins. In humans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2587de6c3db0d7d1924ac7ead8e3660a
https://doi.org/10.1091/mbc.e19-08-0439-t

Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation

Autor: Yoonji Lee, Yuh Min Chook, Rosa Lapalombella, Binita Shakya, Chad A. Brautigam, Nick V. Grishin, Jordan M. Baumhardt, Janek S. Walker

Publikováno v: Molecular Biology of the Cell

The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorigenesis is unclear. Glu571 of CRM1 is located in its nuclear export signal (NES)-binding groove, suggesting that binding of select NESs may be altered. We gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ceca88c37fe6a1865a39b7df108886
http://europepmc.org/articles/PMC7525811

Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance

Autor: Hellicar, John, Stevenson, Nicola L., Stephens, David J., Lowe, Martin

Publikováno v: Hellicar, J, Stevenson, N L, Stephens, D J & Lowe, M 2022, ' Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance ', Journal of Cell Science, vol. 135, no. 1, jcs258879 . https://doi.org/10.1242/jcs.258879
Hellicar, J, Stevenson, N L, Stephens, D J & Lowe, M 2022, ' Supply chain logistics-the role of the Golgi complex in extracellular matrix production and maintenance ', Journal of Cell Science, vol. 135, no. 1, jcs258879 . https://doi.org/10.1242/jcs.258879
Journal of Cell Science
article-version (VoR) Version of Record

The biomechanical and biochemical properties of connective tissues are determined by the composition and quality of their extracellular matrix. This, in turn, is highly dependent on the function and organisation of the secretory pathway. The Golgi co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e85e8ff6d3d3f012e8c0956463848c
https://doi.org/10.1242/jcs.258879

Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1

Autor: Shinya Tashiro, Chie Motono, Kenichiro Imai, Waka Kojima, Kouhei Tsumoto, Mayumi Kimura, Jose M. M. Caaveiro, Noriyuki Matsuda, Chisato Udagawa, Bruno B. Queliconi, Takatsugu Hirokawa, Keiji Tanaka, Koji Yamano

Publikováno v: Journal of Cell Science
article-version (VoR) Version of Record

Diverse genes associated with familial Parkinson's disease (familial Parkinsonism) have been implicated in mitochondrial quality control. One such gene, PARK7 encodes the protein DJ-1, pathogenic mutations of which trigger its translocation from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b7c26a90bd3f495b8f8e5e41c67d9b
https://doi.org/10.1242/jcs.258653