Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Cell Biology and Metabolism"'
Autor:
Jean-Baptiste Manneville, Irene Brian, Silvia Pedretti, Patrizia Romani, Arianna Pocaterra, Mattia Forcato, Silvio Bicciato, Samuel Mathieu, Nico Mitro, Sirio Dupont, Matteo Audano, Giulia Santinon
Publikováno v:
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, In press, ⟨10.1038/s41556-018-0270-5⟩
Nature Cell Biology, Nature Publishing Group, In press, ⟨10.1038/s41556-018-0270-5⟩
International audience; Extracellular matrix (ECM) mechanical cues have powerful effects on cell proliferation, differentiation and death. Here, starting from an unbiased metabolomics approach, we identify synthesis of neutral lipids as a general res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac277feffe338407fa39d7570adb9c85
https://doi.org/10.1038/s41556-018-0270-5
https://doi.org/10.1038/s41556-018-0270-5
Autor:
Audrey Rousseau, Laure-Marie Dardaud, Céline Bris, Valérie Desquiret-Dumas, Blandine Boisselier, Emeline Tabouret, Karima Mokhtari, Dominique Figarella-Branger, Vincent Procaccio
Publikováno v:
Neuro Oncol
Young patients (< 40 years-old) with glioblastoma (GB) may carry IDH1/2 mutations or rarely, H3F3A/HIST1H3B mutations. Some instead harbor chromosome (chr) 7 gain, chr 10 loss, and EGFR amplification (amp). IDH1/2 mutations are associated with longer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7555b89d9f5d61974d80d5ca78afdd
https://europepmc.org/articles/PMC6846881/
https://europepmc.org/articles/PMC6846881/
Publikováno v:
Neuro Oncol
Nicotinamide adenine dinucleotide (NAD) metabolic pathways have been shown to be critical targets in many cancers, including brain tumors. However, inhibiting nicotinamide metabolism has had limited efficacy in the clinic to date due to on-target sid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2221a8ef1285975a462c8af0bfba93a
https://europepmc.org/articles/PMC6847852/
https://europepmc.org/articles/PMC6847852/
Autor:
Jessica Swanner, Nitin Tandon, Yoshihiro Otani, Gabriella Hines, Vasanta Putluri, Yoshua Esquenazi, Pedram Honarpisheh, Takeshi Takayasu, Balveen Kaur, Bhanu P. Ganesh, Anthony Patrizz, Nagireddy Putluri, Louise D. McCullough, Soheil Zorofchain, Leomar Y. Ballester
Publikováno v:
Neuro Oncol
Recent studies demonstrate the potential role of the microbiome in immune-oncology, revealing specific microbial taxa can augment the effects of various therapeutic modalities against tumors. Gut dysbiosis, a disequilibrium in the host’s bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cb00004f1138609afe213fa85988df
https://europepmc.org/articles/PMC6847031/
https://europepmc.org/articles/PMC6847031/
Autor:
Georg Karpel-Massler, Maximilian Pruss, Mike-Andrew Westhoff, Markus D. Siegelin, Annika Dwucet, Rainer Wirtz, Richard E. Kast, Michal Hlavac, Marc-Eric Halatsch
Publikováno v:
Neuro Oncol
BACKGROUND Metabolic dysregulation is a common feature of cancers such as primary brain malignancies. In this work we examined whether a rewiring of the metabolome by a multi-targeting approach would induce enhanced anti-neoplastic activity in gliobl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31074a8da1b01a2c1c5ab827ed6932da
https://europepmc.org/articles/PMC6847679/
https://europepmc.org/articles/PMC6847679/
Publikováno v:
Neuro Oncol
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive Schwann cell (SC)-derived sarcomas with strong metastatic proclivity and resistance to radiation and chemotherapy. Molecular events driving SC-to-MPNST transformation are incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1249b05418f279cedf1c9d173310fa7
https://europepmc.org/articles/PMC6847520/
https://europepmc.org/articles/PMC6847520/
Autor:
Frank Brand, Alisa Förster, Marc S. Raab, Michael Weller, Peter Claus, Carina M. Thome, Ruthild G. Weber, Andreas von Deimling, Martin Bucher, Manfred Westphal, Bettina Hentschel, Torsten Pietsch, Anne Kosfeld, Guido Reifenberger
Publikováno v:
Neuro Oncol
In search of novel genes associated with glioma pathogenesis, we have previously shown that KIAA1797/FOCAD is frequently deleted in malignant gliomas and that the encoded focadhesin functions as a tumor suppressor impacting proliferation and migratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4c184ebc96293a0205069a1165f7a4
https://europepmc.org/articles/PMC6847672/
https://europepmc.org/articles/PMC6847672/
Autor:
Zev A. Binder, Marvin Henze, Stephen J Bagley, Lucy F. Stead, Tim Brend, Nina Struve, Konstantin Hoffer, Thorsten Rieckmann, Claire Faulkner, Anna-Sophie Weik, Ulrich Schüller, Susan C Short, Jasmin Burmester, Leonie Ott, Ann Christin Parplys, Cordula Petersen, Malte Kriegs, Kathreena M Kurian, Kai Rothkamm, Justus Müller-Goebel, Jennifer J.D. Morrissette
Publikováno v:
Neuro Oncol
MGMT promoter methylation is the only accepted biomarker with prognostic role in GBM but its routine implementation is limited partly response to TMZ is heterogeneous, but also due to lack of effective alternative treatment options. Therefore, additi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcb41bbdc8267b85159c1536b40c257
https://europepmc.org/articles/PMC6847190/
https://europepmc.org/articles/PMC6847190/
Autor:
Pravin Kesarwani, Ichiro Nakano, Antony Prabhu, Anthony R. Guastella, Prakash Chinnaiyan, Shiva Kant
Publikováno v:
Neuro Oncol
Despite advances in molecularly characterizing glioblastoma, metabolic alterations driving its aggressive phenotype are only beginning to be recognized. Integrative cross-platform analyses coupling global metabolomic and gene expression profiling ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b226cb6027607bfa94d1136d29c3c404
https://europepmc.org/articles/PMC6847795/
https://europepmc.org/articles/PMC6847795/
Autor:
Yutaro Saito, Shinsuke Sando, Anne Marie Gillespie, Peder E. Z. Larson, Peng Cao, Georgios Batsios, Pavithra Viswanath, Hikari A. I. Yoshihara, Sabrina M. Ronen, Chloé Najac, Elavarasan Subramani
Publikováno v:
Neuro Oncol
γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. The enzyme is localized on the outer cell membrane and cleaves glutathione to glutamate and cysteinylglycine. As such, it facilitates upt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d8eff4a1f51defa7019add642a866
https://europepmc.org/articles/PMC6847274/
https://europepmc.org/articles/PMC6847274/