Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects

Autor: Hong Li, Tiziano Pramparo, Yong Ha Youn, Shinji Hirotsune, Nicholas J. Schork, Anthony Wynshaw-Boris, Sonia Jain, Ondrej Libiger

Publikováno v: PLoS Genetics, Vol 7, Iss 3, p e1001331 (2011)
PLoS Genetics

Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly. LIS1 is part of a protein complex including NDEL1 and 14-3-3ε tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75b7c48399937998223257000c6a37d
http://europepmc.org/articles/PMC3053345?pdf=render

Equivalence of Conventionally-Derived and Parthenote-Derived Human Embryonic Stem Cells

Autor: Jeanne F. Loring, Gabriel Nistor, Louise C. Laurent, David Ferguson, Hans S. Keirstead, L. S. Agapova, Magdalene J. Seiler, Nikolay A. Turovets, Gulsah Altun, Julie V. Harness

Publikováno v: Harness, Julie V.; Turovets, Nikolay A.; Seiler, Magdalene J.; Nistor, Gabriel; Altun, Gulsah; Agapova, Larissa S.; et al.(2011). Equivalence of Conventionally-Derived and Parthenote-Derived Human Embryonic Stem Cells. PLoS ONE, 6(1). UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1t30n65h
PLoS ONE, Vol 6, Iss 1, p e14499 (2011)
PLoS ONE

Background As human embryonic stem cell (hESC) lines can be derived via multiple means, it is important to determine particular characteristics of individual lines that may dictate the applications to which they are best suited. The objective of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d90fa8f565bb6c1c6bd87380c30f90
http://www.escholarship.org/uc/item/1t30n65h

A Novel zf-MYND Protein, CHB-3, Mediates Guanylyl Cyclase Localization to Sensory Cilia and Controls Body Size of Caenorhabditis elegans

Autor: Victor L. Jensen, Laurie L. Molday, Phuong Anh T. Nguyen, Robert S. Molday, Katarzyna Kida, Oliver E. Blacque, Sharon L. Bishop-Hurley, Nathan J. Bialas, Donald L. Riddle, Michel R. Leroux

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001199 (2010)
PLoS Genetics

In harsh conditions, Caenorhabditis elegans arrests development to enter a non-aging, resistant diapause state called the dauer larva. Olfactory sensation modulates the TGF-β and insulin signaling pathways to control this developmental decision. Fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b889904becb45477d4e908fe463eaa64
http://europepmc.org/articles/PMC2991253?pdf=render

Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery

Autor: Eyal D. Schejter, Shaul Yogev, Ben-Zion Shilo

Publikováno v: PLoS Biology, Vol 8, Iss 10 (2010)
PLoS Biology

Trafficking within the endoplasmic reticulum and specialized localization of the intra-membrane protease Rhomboid regulate EGF ligand-dependent signaling in Drosophila photoreceptor axon termini.
The release of signaling molecules from neurons m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39958677ea178144776f8be11a613c09
http://europepmc.org/articles/PMC2950126?pdf=render

Familial CJD associated PrP mutants within transmembrane region induced Ctm-PrP retention in ER and triggered apoptosis by ER stress in SH-SY5Y cells

Autor: Qi Shi, Xin Wang, Cao Chen, Xiao-Ping Dong, Kun Xu, Jun Han, Chen Gao, Xiaoli Li, Gui-Rong Wang, Chan Tian

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14602 (2011)

BackgroundGenetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C)) to the pathogenic one (PrP(Sc)). The pathogenic mechanisms and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ace49b42d9c9c0dba2431d14d73ae0
https://pubmed.ncbi.nlm.nih.gov/21298055