Zobrazeno 1 - 10
of 1 092
pro vyhledávání: '"Cell Biology/Cell Signaling"'
Publikováno v:
PLoS Biology
Chromatin organizer SATB1 and Wnt transducer β-catenin form a complex and regulate expression of GATA3 and TH2 cytokines in Wnt-dependent manner and orchestrate TH2 lineage commitment.
In vertebrates, the conserved Wnt signalling cascade promot
In vertebrates, the conserved Wnt signalling cascade promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3b62f0f2ce8508e6158ff34ff23a558
https://pubmed.ncbi.nlm.nih.gov/20126258
https://pubmed.ncbi.nlm.nih.gov/20126258
Publikováno v:
PLoS ONE
Background Tamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb56cd5561eea2a831a09b12f9594d05
https://pubmed.ncbi.nlm.nih.gov/18270579
https://pubmed.ncbi.nlm.nih.gov/18270579
Publikováno v:
PLoS ONE
Background We recently reported that colon tumor cells stimulate macrophages to release IL-1β, which in turn inactivates GSK3β and enhances Wnt signaling in colon cancer cells, generating a self-amplifying loop that promotes the growth of tumor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b80e1913c0408a5cd94160854b896023
https://pubmed.ncbi.nlm.nih.gov/20661477
https://pubmed.ncbi.nlm.nih.gov/20661477
Autor:
Ayşe Mine Yılmaz, Ömer Birkan Ağrali, Leyla Kuru, Buse Oncu, Betul Karademir, Elif Çiğdem Altunok
Publikováno v:
Volume: 10, Issue: 4 473-473
Clinical and Experimental Health Sciences
Volume: 10, Issue: 2 153-162
Clinical and Experimental Health Sciences
Volume: 10, Issue: 2 153-162
Objective: Tideglusib is a GSK-3 inhibitor activating Wnt/β-catenin signaling pathway which has significant importance in regenerative response.The aim of this study was to evaluate the cytotoxicity and protein expression impacts of Tideglusib on hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c17244f6ef5f4023dcd951dcbaafb0
https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/59063/840278
https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/59063/840278
Autor:
Malgorzata S. Martin-Gronert, Heidi Storgaard, Susan E. Ozanne, Christine B. Jensen, Sten Madsbad, Allan Vaag
Publikováno v:
PLoS ONE
PLoS ONE, Vol 3, Iss 11, p e3738 (2008)
PLoS ONE, Vol 3, Iss 11, p e3738 (2008)
BACKGROUND: Low birth weight (LBW) is associated with increased future risk of insulin resistance and type 2 diabetes mellitus. The underlying molecular mechanisms remain poorly understood. We have previously shown that young LBW men have reduced ske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c190e1a8415620c23110c28fc63a4ac
Autor:
Judith M.E.M. Cosemans, Matthew T. Harper, Johan W. M. Heemskerk, Karen Gilio, Alastair W. Poole, Kellie J. Hall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)
BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0816b62cd637f333d1eaaef3e6ee83
Autor:
Bertrand Tavitian
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228838 (2020)
PLoS ONE
PLoS ONE
The hope of success of therapeutic interventions largely relies on the possibility to distinguish between even close tumor types with high accuracy. Indeed, in the last ten years a major challenge to predict the responsiveness to a given therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf50c1a586893ef5cf68bcba2822a18
https://doaj.org/article/8f5e55c0be424f858b21094d42e1782d
https://doaj.org/article/8f5e55c0be424f858b21094d42e1782d
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e10159 (2010)
PLoS ONE, Vol 5, Iss 4, p e10159 (2010)
Background: Migration of mammalian cells is a complex cell type and environment specific process. Migrating hematopoietic cells assume a rapid amoeboid like movement when exposed to gradients of chemoattractants. The underlying signaling mechanisms r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32fe56b65208ee23787b09752c7cd35f
http://doc.rero.ch/record/324654/files/volpe_plosone_2010.pdf
http://doc.rero.ch/record/324654/files/volpe_plosone_2010.pdf
Publikováno v:
PLoS ONE
Background Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14463bf8c28ebea46d88501b705c6243
https://pubmed.ncbi.nlm.nih.gov/20352118
https://pubmed.ncbi.nlm.nih.gov/20352118
Autor:
Merel Gijsen, Peter King, Tim Perera, Peter J. Parker, Adrian L. Harris, Banafshé Larijani, Anthony Kong
Publikováno v:
King's College London
PLoS Biology
PLoS Biology, Vol 8, Iss 12, p e1000563 (2010)
PLoS Biology
PLoS Biology, Vol 8, Iss 12, p e1000563 (2010)
A feedback loop maintains HER2 receptor signalling and cell survival in response to Herceptin treatment in HER2-positive breast cancers, but this Herceptin resistance may be bypassed by pan-HER inhibitors.
Herceptin (trastuzumab) is used in pati
Herceptin (trastuzumab) is used in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cce95d5e3b2533160dd248a7c7433b
https://ora.ox.ac.uk/objects/uuid:a5855cb1-2290-484e-a521-ce4d4c329dae
https://ora.ox.ac.uk/objects/uuid:a5855cb1-2290-484e-a521-ce4d4c329dae