Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Cell Biology/Cell Adhesion"'
Publikováno v:
PLoS ONE
Background Tamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase i
Autor:
Judith M.E.M. Cosemans, Matthew T. Harper, Johan W. M. Heemskerk, Karen Gilio, Alastair W. Poole, Kellie J. Hall
Publikováno v:
PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)
BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0816b62cd637f333d1eaaef3e6ee83
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12766 (2010)
PLoS ONE, Vol 5, Iss 9, p e12766 (2010)
Background: Thymopoiesis requires thymocyte-stroma interactions and proteases that promote cell migration by degrading extracellular matrix and releasing essential cytokines and chemokines. A role for several members of the A Disintegrin and Metallop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe53cefe5b2f0a9afbc6450dd1dc220
https://doi.org/10.1371/journal.pone.0012766
https://doi.org/10.1371/journal.pone.0012766
Autor:
Tünde Szatmári, George N. Tzanakakis, Anders Hjerpe, David Brodin, Katalin Dobra, Ilona Kovalszky, Filip Mundt, László Szilák, Fang Zong, Eleni Fthenou
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 6, p e14816 (2011)
PLoS ONE, Vol 6, Iss 6, p e14816 (2011)
BackgroundSyndecans are proteoglycans whose core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan chains. Syndecans are involved in many important cellular proce
Autor:
William J. Adams, Po-Ling Kuo, Mark-Anthony Bray, Anna Grosberg, Chin-Lin Guo, Kevin Kit Parker, Sean P. Sheehy, Nicholas A. Geisse
Publikováno v:
PLoS computational biology, vol 7, iss 2
PLoS Computational Biology
PLoS Computational Biology, Vol 7, Iss 2, p e1001088 (2011)
PLoS Computational Biology
PLoS Computational Biology, Vol 7, Iss 2, p e1001088 (2011)
The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to physically constrain the muscle c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a03af56dff0d71e89484f1113cfc811a
https://escholarship.org/uc/item/94b8q03m
https://escholarship.org/uc/item/94b8q03m
Autor:
Ellen Knuepfer, Arnab Pain, Steven Howell, Solabomi A. Ogun, Deirdre Cunningham, Anthony A. Holder, Thomas D. Otto, Rita Tewari, Zhengyao Xu
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1001288 (2011)
PLoS Pathogens; Vol 7
PLoS Pathogens
PLoS Pathogens; Vol 7
PLoS Pathogens
Plasmodium yoelii YM asexual blood stage parasites express multiple members of the py235 gene family, part of the super-family of genes including those coding for Plasmodium vivax reticulocyte binding proteins and Plasmodium falciparum RH proteins. W
Autor:
Jeanne F. Loring, Gabriel Nistor, Louise C. Laurent, David Ferguson, Hans S. Keirstead, L. S. Agapova, Magdalene J. Seiler, Nikolay A. Turovets, Gulsah Altun, Julie V. Harness
Publikováno v:
Harness, Julie V.; Turovets, Nikolay A.; Seiler, Magdalene J.; Nistor, Gabriel; Altun, Gulsah; Agapova, Larissa S.; et al.(2011). Equivalence of Conventionally-Derived and Parthenote-Derived Human Embryonic Stem Cells. PLoS ONE, 6(1). UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1t30n65h
PLoS ONE, Vol 6, Iss 1, p e14499 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14499 (2011)
PLoS ONE
Background As human embryonic stem cell (hESC) lines can be derived via multiple means, it is important to determine particular characteristics of individual lines that may dictate the applications to which they are best suited. The objective of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d90fa8f565bb6c1c6bd87380c30f90
http://www.escholarship.org/uc/item/1t30n65h
http://www.escholarship.org/uc/item/1t30n65h
Autor:
Xinran Xiang, Kunio Nagashima, Yen Phung, V. Courtney Broaddus, Mitchell Ho, Jingli Zhang, Mingqian Feng, David J. FitzGerald, Raffit Hassan
Publikováno v:
PloS one, vol 6, iss 1
PLoS ONE, Vol 6, Iss 1, p e14640 (2011)
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14640 (2011)
PLoS ONE
Background Tumor microenvironments present significant barriers to penetration by antibodies and immunoconjugates. Tumor microenvironments, however, are difficult to study in vitro. Cells cultured as monolayers exhibit less resistance to therapy than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376949dc9aa058a43554bac2fc27b682
https://escholarship.org/uc/item/2n59x3zf
https://escholarship.org/uc/item/2n59x3zf
Autor:
Herman H. H. B. M. van Haagen, Antoine de Morrée, Peter A C 't Hoen, Irina Dragan, Paul J. Hensbergen, André M. Deelder, Rune R. Frants, Silvère M. van der Maarel
Publikováno v:
PLoS ONE, 5(11), e13854
PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13854 (2010)
PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13854 (2010)
Dysferlin is critical for repair of muscle membranes after damage. Mutations in dysferlin lead to a progressive muscular dystrophy. Recent studies suggest additional roles for dysferlin. We set out to study dysferlin's protein-protein interactions to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e446d48a3b9fdf1da0f21bf48528be51
http://hdl.handle.net/1887/118967
http://hdl.handle.net/1887/118967
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14348 (2010)
PLoS ONE
PLoS ONE
Background: Dilated cardiomyopathy (DCM) is a severe cardiac condition that causes high mortality. Many genes have been confirmed to be involved in this disease. An ideal system with which to uncover disease mechanisms would be one that can measure t