Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Autor: Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter

Publikováno v: Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, 't Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Slieker, R C, Donnelly, L A, Akalestou, E, Lopez-Noriega, L, Melhem, R, Güneş, A, Abou Azar, F, Efanov, A, Georgiadou, E, Muniangi-Muhitu, H, Sheikh, M, Giordano, G N, Åkerlund, M, Ahlqvist, E, Ali, A, Banasik, K, Brunak, S R, Barovic, M, Bouland, G A, Burdet, F, Canouil, M, Dragan, I, Elders, P J M, Fernandez, C, Festa, A, Fitipaldi, H, Froguel, P, Gudmundsdottir, V, Gudnason, V, Gerl, M J, van der Heijden, A A, Jennings, L L, Hansen, M K, Kim, M, Leclerc, I, Klose, C, Kuznetsov, D, Mansour Aly, D, Mehl, F, Marek, D, Melander, O, Niknejad, A, Ottosson, F, Pavo, I, Duffin, K, Syed, S K, Shaw, J L, Cabrera, O, Pullen, T J, Simons, K, Solimena, M, Suvitaival, T, Wretlind, A, Rossing, P, Lyssenko, V, Legido Quigley, C, Groop, L, Thorens, B, Franks, P W, Lim, G E, Estall, J, Ibberson, M, Beulens, J W J, ’t Hart, L M, Pearson, E R & Rutter, G A 2023, ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ', Nature Communications, vol. 14, no. 1, 2533 . https://doi.org/10.1038/s41467-023-38148-7
Nature Communications, 14(1):2533. Nature Publishing Group UK

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacylglycerol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1654ea5cf5cf5976c8684f5b8cb7ed
https://curis.ku.dk/portal/da/publications/identification-of-biomarkers-for-glycaemic-deterioration-in-type-2-diabetes(32aaa1f9-fa85-4d91-83f7-6715b74bca9e).html

SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering

Autor: Ka Wan Li, Fatima Farzana, Frank Koopmans, August B. Smit, Jessie W. Brunner, Silvia Oldani, Matthijs Verhage, Marinka Brouwer, Ruud F. Toonen, Ning Chen, Jan R.T. van Weering

Publikováno v: Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R T, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289 . https://doi.org/10.15252/embj.2018101289
EMBO Journal, 38(17):e101289, 1-20. Nature Publishing Group
EMBO Journal, 38(17):e101289. Wiley-Blackwell
Brouwer, M, Farzana, F, Koopmans, F, Chen, N, Brunner, J W, Oldani, S, Li, K W, van Weering, J R, Smit, A B, Toonen, R F & Verhage, M 2019, ' SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering ', EMBO Journal, vol. 38, no. 17, e101289, pp. 1-20 . https://doi.org/10.15252/embj.2018101289
The EMBO Journal

Synapse development requires spatiotemporally regulated recruitment of synaptic proteins. In this study, we describe a novel presynaptic mechanism of cis‐regulated oligomerization of adhesion molecules that controls synaptogenesis. We identified sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccd74ba8c64f4a684dea731fcb80231
https://doi.org/10.15252/embj.2018101289

The effect of helminths on granulocyte activation : a cluster-randomized placebo-controlled trial in Indonesia

Autor: Erliyani Sartono, Leo Koenderman, Thomas B. Nutman, Karin de Ruiter, Johannes W. A. Smit, Taniawati Supali, Maria Yazdanbakhsh, Dicky L. Tahapary

Publikováno v: Journal of Infectious Diseases, 219(9), 1474. Oxford University Press
The Journal of Infectious Diseases, 219, 1474-1482
The Journal of Infectious Diseases, 219, 9, pp. 1474-1482
Journal of Infectious Diseases, 219(9), 1474-1482. OXFORD UNIV PRESS INC

Item does not contain fulltext BACKGROUND: Eosinophils are a prominent cell type in the host response to helminths, and some evidence suggests that neutrophils might also play a role. However, little is known about the activation status of these gran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e63a3d16b4bbe4dccb832ca424c31f0
https://dspace.library.uu.nl/handle/1874/390519

A high mucosal blocking score is associated with HIV protection

Autor: Mario Clerici, Bernard Verrier, Norma Rallón, Blandine Chanut, Jorge del Romero, Alexandre Girard, Christian Genin, Stéphane Paul, Mara Biasin, Frédéric Lucht, Fabienne Jospin, José M. Benito, Jean Jacques Pin, Fahd Benjelloun, Carmen Rodríguez

Publikováno v: AIDS
AIDS, Lippincott, Williams & Wilkins, 2019, 33 (3), pp.411-423. ⟨10.1097/QAD.0000000000002099⟩
AIDS. Official journal of the international AIDS Society
AIDS. Official journal of the international AIDS Society, 2019, 33 (3), pp.411-423. ⟨10.1097/QAD.0000000000002099⟩

International audience; BACKGROUND:Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as α4β7 and the C-type lectins DC-SIGN and langerin. Previously Env-specific B-cell responses have been reported in hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e526359b0fc46cf5230fb418fcd34f
https://hal.archives-ouvertes.fr/hal-02351387

H3K9MTase G9a is essential for the differentiation and growth of tenocytes in vitro

Autor: Wada, S., Ideno, H., Shimada, A., Kamiunten, T., Nakamura, Y., Nakashima, K., Kimura, Hiroshi, Shinkai, Y., Tachibana, M., Nifuji, A.

Publikováno v: Histochemistry and Cell Biology. 144:13-20

Cell differentiation is controlled by specific transcription factors. The functions and expression levels of these transcription factors are regulated by epigenetic modifications, such as histone modifications and cytosine methylation of the genome.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca23016b0b66d867d785cfbdbb154ea
https://doi.org/10.1007/s00418-015-1318-2