The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

Autor: Kobialka, Piotr, Sabata, Helena, Vilalta, Odena, Gouveia, Leonor, Angulo-Urarte, Ana, Muixí, Laia, Zanoncello, Jasmina, Muñoz-Aznar, Oscar, Olaciregui, Nagore G., Fanlo, Lucia, Esteve-Codina, Anna, Lavarino, Cinzia, Javierre, B. M, Celis, Verónica Paola, Rovira, Cinzia, López-Fernández, Susana, Baselga Torres, Eulàlia, Mora, J., Castillo, Sandra D., Graupera, Mariona, Universitat Autònoma de Barcelona. Departament de Cirurgia

Publikováno v: EMBO Molecular Medicine
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu

Low-flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs. These diseases are caused by oncogenic mutations in the endothelium, which result in

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http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485842