Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a Gα; i/o; protein inhibitor

Autor: Alessandra Porcu, Miriam Melis, Bernhard Bettler, Rostislav Turecek, Ignazia Mocci, Gian Luigi Gessa, Celine Ullrich, M. Paola Castelli

Publikováno v: Neuropharmacology 133 (2018): 107–120. doi:10.1016/j.neuropharm.2018.01.024
info:cnr-pdr/source/autori:Porcu A, Melis M, Turecek R, Ullrich C, Mocci I, Bettler B, Gessa GL, Castelli MP./titolo:Rimonabant, a potent CB1 cannabinoid receptor antagonist, is a G?(i%2Fo) protein inhibitor/doi:10.1016%2Fj.neuropharm.2018.01.024/rivista:Neuropharmacology/anno:2018/pagina_da:107/pagina_a:120/intervallo_pagine:107–120/volume:133

Rimonabant is a potent and selective cannabinoid CB1 receptor antagonist widely used in animal and clinical studies. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd14ef8453f3c0ffb9727e91fdb52a9a

Homocysteine has anti-inflammatory properties in a hypercholesterolemic rat model in vivo

Autor: Michael Pirchl, Christian Humpel, Celine Ullrich, Barbara Sperner-Unterweger

Publikováno v: Molecular and Cellular Neuroscience; Vol 49
Molecular and Cellular Neurosciences

Inflammation is a hallmark in many neurodegenerative diseases like Alzheimer's disease or vascular dementia. Cholesterol and homocysteine are both vascular risk factors which have been associated with dementia, inflammation and blood-brain barrier dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bb8eb8c9fd26ccca6011562b2a67e3
https://doi.org/10.1016/j.mcn.2012.03.001

Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices

Autor: Barbara Sperner-Unterweger, Celine Ullrich, Tanja Hochstrasser, Christian Humpel

Publikováno v: Neuroscience; Vol 184

Neuroinflammation results in dysregulation of serotonergic neurons in the dorsal raphe nucleus (doR) and is considered to play an important role in the pathophysiology of depression. The aim of the present study was to induce neuroinflammation in a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b8b997657765403a0387d52df920e1
https://doi.org/10.1016/j.neuroscience.2011.03.070

Differential effects of short- and long-term hyperhomocysteinaemia on cholinergic neurons, spatial memory and microbleedings in vivo in rats

Autor: Christian Humpel, Michael Pirchl, Celine Ullrich

Publikováno v: European Journal of Neuroscience. 32:1516-1527

Hyperhomocysteinaemia (HHcy) has been identified as a cardiovascular risk factor for neurodegenerative brain diseases. The aim of the present study was to investigate the effects of short (5 months) or long (15 months) HHcy in Sprague–Dawley rats i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bdd59c2dfbc095fa5ea6eccb1ee37a4
https://doi.org/10.1111/j.1460-9568.2010.07434.x

Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficits

Autor: Michael Pirchl, Celine Ullrich, Christian Humpel

Publikováno v: Molecular and Cellular Neurosciences

Alzheimer's disease (AD) is a chronic brain disorder characterized by cognitive impairment, cholinergic dysfunction, inflammation, tau and beta-amyloid pathology and vascular damage. Recent studies have shown, that high cholesterol levels are linked

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc2554780ae9b6a00aa862219320c4f
http://europepmc.org/articles/PMC2977849