Association of EDARV370A with breast density and metabolic syndrome in Latinos.

Autor: Dawn K Coletta, Leslea J Hlusko, G Richard Scott, Luis A Garcia, Celine M Vachon, Aaron D Norman, Janet L Funk, Gabriel Q Shaibi, Valentina Hernandez, Eleanna De Filippis, Lawrence J Mandarino

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0258212 (2021)

The ectodysplasin receptor (EDAR) is a tumor necrosis factor receptor (TNF) superfamily member. A substitution in an exon of EDAR at position 370 (EDARV370A) creates a gain of function mutant present at high frequencies in Asian and Indigenous Americ

Externí odkaz: https://doaj.org/article/98ad19f444354eda9b5ecc5d49f135c6

Mosaic chromosomal alterations (mCAs) in individuals with monoclonal B-cell lymphocytosis (MBL)

Autor: Aswin Sekar, Rosalie Griffin, Sameer A. Parikh, Giulio Genovese, Dennis P. Robinson, Aaron D. Norman, Janet E. Olson, Kari G. Rabe, Mingma S. Hoel, Nicholas J. Boddicker, Paul J. Hampel, Neil E. Kay, James R. Cerhan, Esteban Braggio, Curtis A. Hanson, Celine M. Vachon, Tait D. Shanafelt, Benjamin L. Ebert, Susan L. Slager

Publikováno v: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-8 (2024)

Abstract MBL is a precursor condition to chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cells in blood. Mosaic chromosomal alterations (mCAs) are a form of clonal hematopoiesis that include gains, losses, and copy-neutral loss-of-h

Externí odkaz: https://doaj.org/article/c4ee9d74bb144a50aa27abf28e99a8eb

Using Breast Cancer Risk Associated Polymorphisms to Identify Women for Breast Cancer Chemoprevention.

Autor: Elad Ziv, Jeffrey A Tice, Brian Sprague, Celine M Vachon, Steven R Cummings, Karla Kerlikowske

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0168601 (2017)

BACKGROUNDBreast cancer can be prevented with selective estrogen receptor modifiers (SERMs) and aromatase inhibitors (AIs). The US Preventive Services Task Force recommends that women with a 5-year breast cancer risk ≥3% consider chemoprevention fo

Externí odkaz: https://doaj.org/article/36363851e5b442858032aceb6f426e45

Association of early menarche with breast tumor molecular features and recurrence

Autor: Alexandra R. Harris, Tengteng Wang, Yujing J. Heng, Gabrielle M. Baker, Phuong Anh Le, Jun Wang, Christine Ambrosone, Adam Brufsky, Fergus J. Couch, Francesmary Modugno, Christopher G. Scott, Celine M. Vachon, Susan E. Hankinson, Bernard A. Rosner, Rulla M. Tamimi, Cheng Peng, A. Heather Eliassen

Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-14 (2024)

Abstract Background Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. Methods We profiled transcriptome-wide gene expression in breast tumors (N = 846) and tu

Externí odkaz: https://doaj.org/article/76b5bacfbc8949afa92769f09a2daa34

Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.

Autor: Stefan Nickels, Thérèse Truong, Rebecca Hein, Kristen Stevens, Katharina Buck, Sabine Behrens, Ursula Eilber, Martina Schmidt, Lothar Häberle, Alina Vrieling, Mia Gaudet, Jonine Figueroa, Nils Schoof, Amanda B Spurdle, Anja Rudolph, Peter A Fasching, John L Hopper, Enes Makalic, Daniel F Schmidt, Melissa C Southey, Matthias W Beckmann, Arif B Ekici, Olivia Fletcher, Lorna Gibson, Isabel dos Santos Silva, Julian Peto, Manjeet K Humphreys, Jean Wang, Emilie Cordina-Duverger, Florence Menegaux, Børge G Nordestgaard, Stig E Bojesen, Charlotte Lanng, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina A Clarke, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Hiltrud Brauch, Thomas Brüning, Volker Harth, Genica Network, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, kConFab, AOCS Management Group, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Robert Paridaens, Dieter Flesch-Janys, Nadia Obi, Shan Wang-Gohrke, Fergus J Couch, Janet E Olson, Celine M Vachon, Graham G Giles, Gianluca Severi, Laura Baglietto, Kenneth Offit, Esther M John, Alexander Miron, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Stephen J Chanock, Jolanta Lissowska, Jianjun Liu, Angela Cox, Helen Cramp, Dan Connley, Sabapathy Balasubramanian, Alison M Dunning, Mitul Shah, Amy Trentham-Dietz, Polly Newcomb, Linda Titus, Kathleen Egan, Elizabeth K Cahoon, Preetha Rajaraman, Alice J Sigurdson, Michele M Doody, Pascal Guénel, Paul D P Pharoah, Marjanka K Schmidt, Per Hall, Doug F Easton, Montserrat Garcia-Closas, Roger L Milne, Jenny Chang-Claude

Publikováno v: PLoS Genetics, Vol 9, Iss 3, p e1003284 (2013)

Various common genetic susceptibility loci have been identified for breast cancer; however, it is unclear how they combine with lifestyle/environmental risk factors to influence risk. We undertook an international collaborative study to assess gene-e

Externí odkaz: https://doaj.org/article/20dd238908a94b65824d842f548c2872