Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Celine M Laffont"'
Autor:
Laurence M Moss, Marijke Hyke Algera, Robert Dobbins, Frank Gray, Stephanie Strafford, Amy Heath, Monique van Velzen, Jules A A C Heuberger, Marieke Niesters, Erik Olofsen, Celine M Laffont, Albert Dahan, Geert Jan Groeneveld
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0256752 (2022)
BackgroundOpioid-induced respiratory depression driven by ligand binding to mu-opioid receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist, binds with high affinity to mu-opioid receptors but displays partial re
Externí odkaz:
https://doaj.org/article/eb0051078bd44d70bf246c8aab572e7d
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
IntroductionUsing a validated translational model that quantitatively predicts opioid-induced respiratory depression and cardiac arrest, we compared cardiac arrest events caused by synthetic opioids (fentanyl, carfentanil) following rescue by intrana
Externí odkaz:
https://doaj.org/article/6680e0efae9f45fa90e216c8d4945fcf
Publikováno v:
Harm Reduction Journal, Vol 20, Iss 1, Pp 1-13 (2023)
Abstract Background BUP-XR (SUBLOCADE®) is the first buprenorphine extended-release subcutaneous injection approved in the USA for monthly treatment of moderate-to-severe opioid use disorder (OUD). Among patients with OUD, those who inject or use hi
Externí odkaz:
https://doaj.org/article/c923bb74f49c412ea6b467cd77d997da
Autor:
Celine M. Laffont, Eliford Ngaimisi, Mathangi Gopalakrishnan, Vijay Ivaturi, Malcolm Young, Mark K. Greenwald, Christian Heidbreder
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The severity of the ongoing opioid crisis, recently exacerbated by the COVID-19 pandemic, emphasizes the importance for individuals suffering from opioid use disorder (OUD) to have access to and receive efficacious, evidence-based treatments. Optimal
Externí odkaz:
https://doaj.org/article/f20f95ba52094210b8eddc063199a43d
Autor:
Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L. Dobbins, Geert J. Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M. Laffont
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
BACKGROUND Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression. Treatment with the high-affinity mu-opioid receptor partial agonist buprenorphine may preven
Externí odkaz:
https://doaj.org/article/faf5c86fc2f348318525716d62bbc243
Autor:
Anne Le Moigne, Richard C. Crist, Emily E. Hartwell, Anne C Andorn, Kevin G. Lynch, Celine M Laffont, Henry R. Kranzler
Publikováno v:
International Journal of Neuropsychopharmacology
Background Buprenorphine treatment is not equally effective in all patients with opioid use disorder (OUD). Two retrospective studies showed that, among African Americans (AAs), rs678849, a polymorphism in the delta-opioid receptor gene, moderated th
Autor:
Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L. Dobbins, Geert J. Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M. Laffont
Publikováno v:
JCI Insight, 7(9). AMER SOC CLINICAL INVESTIGATION INC
BACKGROUND. Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression. Treatment with the high-affinity mu-opioid receptor partial agonist buprenorphine may preve
Autor:
Laurence M. Moss, Marijke Hyke Algera, Robert Dobbins, Frank Gray, Stephanie Strafford, Amy Heath, Monique van Velzen, Jules A. A. C. Heuberger, Marieke Niesters, Erik Olofsen, Celine M. Laffont, Albert Dahan, Geert Jan Groeneveld
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0256752 (2022)
PLoS ONE, 17(1). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 17, Iss 1, p e0256752 (2022)
PLoS ONE, 17(1). PUBLIC LIBRARY SCIENCE
BackgroundOpioid-induced respiratory depression driven by ligand binding to mu-opioid receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial agonist, binds with high affinity to mu-opioid receptors but displays partial re
Autor:
Laurence M Moss, Jules A. A. C. Heuberger, Robert L. Dobbins, Marieke Niesters, Celine M. Laffont, Erik Olofsen, Marijke Hyke Algera, Albert Dahan, Monique van Velzen, Geert Jan Groeneveld
Publikováno v:
Clinical Pharmacology and Therapeutics
Clinical Pharmacology & Therapeutics, 109(3), 637-645. WILEY
Clinical Pharmacology & Therapeutics, 109(3), 637-645. WILEY
Chronic opioid consumption is associated with addiction, physical dependence, and tolerance. Tolerance results in dose escalation to maintain the desired opioid effect. Intake of high-dose or potent opioids may cause life-threatening respiratory depr
Autor:
Ruihua Dong, Hongyun Wang, Dandan Li, Liwei Lang, Frank Gray, Yongzhen Liu, Celine M. Laffont, Malcolm Young, Ji Jiang, Zeyuan Liu, Susan M. Learned
Publikováno v:
Drugs in R&D, Vol 19, Iss 3, Pp 255-265 (2019)
Abstract Background Two phase I studies assessed the pharmacokinetics of buprenorphine, its metabolite norbuprenorphine, and naloxone following administration of buprenorphine/naloxone sublingual tablets in Chinese participants. Methods In the first
Externí odkaz:
https://doaj.org/article/79bde2a917974800ab91d5b4112163f5