Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Celine I. Maeder"'
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2709-2722 (2018)
Summary: The proper assembly of neural circuits depends on the process of synaptogenesis, or the formation of synapses between partner neurons. Using the dopaminergic PDE neurons in C. elegans, we developed an in vivo system to study the earliest ste
Externí odkaz:
https://doaj.org/article/d5455ed65f9549039c516ff82cb6741a
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Microtubule dynamics are essential for axonal transport. InC. elegans, the authors show that dynein heavy chain regulates the spatial distribution of dendritic microtubules which ensures correct transport progression.
Externí odkaz:
https://doaj.org/article/acbd2dc35519436e934590589aaef8f4
SummaryAt a typical synapse, the precise juxtaposition between the active zone and postsynaptic receptors ensures local and precise neurotransmitter release and detection. Dopamine neurons release neurotransmitter more diffusely using volume-transmis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0b460a4c3c4c9fc87094e911547bc7
https://doi.org/10.1101/284042
https://doi.org/10.1101/284042
Autor:
Qi Li, Jun B. Ding, Ji-hyung Kim, Li Z, Shawn Xu X, Konstantin Kaganovsky, Ao Shen, Celine I. Maeder, Kang Shen, Yang Kevin Xiang, Jin Billy Li
SummarySynaptic vesicle and active zone proteins are required for synaptogenesis. The molecular mechanisms for coordinated synthesis of these proteins are not understood. Using forward genetic screens, we identified the conserved THO nuclear export C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635f4095b94991bc0de95f932a9e13ee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does not involve dynein's role as a retrograde motor in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cfe5870841eeae04fac0a7345ba0ce
https://doi.org/10.1038/ncomms15063
https://doi.org/10.1038/ncomms15063
Publikováno v:
Traffic. 15:273-291
During synapse development, synaptic proteins must be targeted to sites of presynaptic release. Directed transport as well as local sequestration of synaptic vesicle precursors (SVPs), membranous organelles containing many synaptic proteins, might co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936943fc2b46d841cee81d8b4caa4832
https://doi.org/10.1111/tra.12142
https://doi.org/10.1111/tra.12142
Autor:
Amanda H. Kahn-Kirby, Kevin G. Hoff, Stephanie Malone, Simon C. Johnson, Matthew B. Klein, Gregory M. Enns, Rosalba Carrozzo, William D. Shrader, Carlo Dionisi-Vici, Joey C. Latham, Virna Kim, Steve Sideris, Lynne A. Wolfe, Yuko Kosaka, Jeffrey K. Trimmer, Kimberly A. Chapman, Celine I. Maeder, Akiko Amagata, Charles R. Holst, Andrew W. Hinman, Enrico Bertini, Diego Martinelli, Russell P. Saneto, Leslie Wang, Euan A. Ashley, Janet J. Mei, Joel J. Bruegger, William A. Gahl, Matthew T. Wheeler
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0214250 (2019)
PLoS ONE, Vol 14, Iss 3, p e0214250 (2019)
Background Mitochondrial disease is a family of genetic disorders characterized by defects in the generation and regulation of energy. Epilepsy is a common symptom of mitochondrial disease, and in the vast majority of cases, refractory to commonly us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d66c44cbd3650832d9a4468e484320
https://doi.org/10.1371/journal.pone.0214250
https://doi.org/10.1371/journal.pone.0214250
Autor:
Celine I. Maeder, Kang Shen
Publikováno v:
Current Opinion in Neurobiology. 21:93-99
Nervous systems are built of a myriad of neurons connected by an even larger number of synapses. While it has been long known that neurons specifically select their synaptic partners among many possible choices during development, we only begin to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754cac6bfdef41045f5e22396e501e05
https://doi.org/10.1016/j.conb.2010.10.004
https://doi.org/10.1016/j.conb.2010.10.004
Autor:
Jun B. Ding, Celine I. Maeder, Sui Wang, Yang Kevin Xiang, Konstantin Kaganovsky, Ao Shen, X.Z. Shawn Xu, Kang Shen, Zhaoyu Li, Qin Li, Jae-Ick Kim, Xing Liang, Jin Billy Li
Publikováno v:
Cell, vol 174, iss 6
Synaptic vesicle and active zone proteins are required for synaptogenesis. The molecular mechanisms for coordinated synthesis of these proteins are not understood. Using forward genetic screens, we identified the conserved THO nuclear export complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0af0e9db7bf04b570da38baa1d38065
https://doi.org/10.1016/j.cell.2018.07.046
https://doi.org/10.1016/j.cell.2018.07.046
Autor:
Kenji Kontani, Emily K. Lehrman, Celine I. Maeder, Miriam B. Goodman, Toshiaki Katada, George Wang, Shohei Mitani, Keiko Gengyo-Ando, Ye E. Wu, Minoru Tada, Kang Shen, Juan G. Cueva, Isei Nakae, Matthew P. Klassen
Publikováno v:
Neuron. 66:710-723
SummaryPresynaptic assembly requires the packaging of requisite proteins into vesicular cargoes in the cell soma, their long-distance microtubule-dependent transport down the axon, and, finally, their reconstitution into functional complexes at presp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966797242160c48d9b2cd5f480cb5fd4
https://doi.org/10.1016/j.neuron.2010.04.033
https://doi.org/10.1016/j.neuron.2010.04.033