Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

Autor: Filipa M Lopes, Celine Grenier, Benjamin W Jarvis, Sara Al Mahdy, Adrian Lène-McKay, Alison M Gurney, William G Newman, Simon N Waddington, Adrian S Woolf, Neil A Roberts

Publikováno v: eLife, Vol 13 (2024)

Rare early-onset lower urinary tract disorders include defects of functional maturation of the bladder. Current treatments do not target the primary pathobiology of these diseases. Some have a monogenic basis, such as urofacial, or Ochoa, syndrome (U

Externí odkaz: https://doaj.org/article/c7e0ce9ab0724cbca7d1f7f2cbe62eae

Neurogenic defects underlie functional bladder outflow tract obstruction associated with biallelic variants inLRIG2

Autor: Celine Grenier, Filipa M. Lopes, Anna M Cueto-González, Eulàlia Rovira-Moreno, Romy Gander, Benjamin W Jarvis, Karen D. McCloskey, Alison M. Gurney, Glenda M. Beaman, William G. Newman, Adrian S. Woolf, Neil A. Roberts

Urinary tract malformations account for half of all children with kidney failure, and some have defined monogenic causes. One such disorder is urofacial, or Ochoa, syndrome (UFS), an autosomal recessive disease featuring a dyssynergic bladder with de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e49d20332dfbc5e75ea504b3170f62
https://doi.org/10.1101/2022.12.06.22283097

High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice

Autor: Hannah M Costello, Georgios Krilis, Celine Grenier, David Severs, Alicja Czopek, Jessica R Ivy, Mark Nixon, Megan C Holmes, Dawn E W Livingstone, Ewout J Hoorn, Neeraj Dhaun, Matthew A Bailey

Publikováno v: Costello, H, Krilis, G, Grenier, C, Severs, D, Czopek, A, Ivy, J R, Nixon, M, Holmes, M C, Livingstone, D E W, Hoorn, E J, Dhaun, N & Bailey, M A 2022, ' High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvac160

Aims High salt intake is common and contributes to poor cardiovascular health. Urinary sodium excretion correlates directly with glucocorticoid excretion in humans and experimental animals. We hypothesized that high salt intake activates the hypothal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96df43a514d5a254e7661b3ca6a200a1
https://pubmed.ncbi.nlm.nih.gov/36368681

Adaptation of C57BL/6J Mice to High Dietary Salt

Autor: Neeraj Dhaun, Celine Grenier, Ailsa F. Ralph, Matthew A. Bailey, Kevin Stewart, Hannah M. Costello

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f962c7607e1cf4ebe873ab1698b07f9d
https://doi.org/10.1096/fasebj.2019.33.1_supplement.866.1

0259 : Neutrophil and thrombospondin-1 implications in flow-mediated remodeling of resistance arteries from mice

Autor: Laurent Loufrani, Tristan Champin, Daniel Henrion, Olivier Blanc-Brude, Celine Grenier

Publikováno v: Archives of Cardiovascular Diseases Supplements. 8(3)

On vascular endothelium, shear stress produces vasorelaxation and outward arterial remodeling. A chronic increase in blood flow induces arterial diameter expansion (normalizing shear stress), and is associated with a compensatory hypertrophy to norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b361cabb9595d02a89cfb3edc0c6da71