Correction: Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

Autor: Gabriella Assante, Sriram Chandrasekaran, Stanley Ng, Aikaterini Tourna, Carolina H. Chung, Kowsar A. Isse, Jasmine L. Banks, Ugo Soffientini, Celine Filippi, Anil Dhawan, Mo Liu, Steven G. Rozen, Matthew Hoare, Peter Campbell, J. William O. Ballard, Nigel Turner, Margaret J. Morris, Shilpa Chokshi, Neil A. Youngson

Publikováno v: Genome Medicine, Vol 15, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/eb93debd63754739be2c1d678c35747f

Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure.

Autor: Suttiruk Jitraruch, Anil Dhawan, Robin D Hughes, Celine Filippi, Daniel Soong, Christina Philippeos, Sharon C Lehec, Nigel D Heaton, Maria S Longhi, Ragai R Mitry

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113609 (2014)

Intraperitoneal transplantation of alginate-microencapsulated human hepatocytes is an attractive option for the management of acute liver failure (ALF) providing short-term support to allow native liver regeneration. The main aim of this study was to

Externí odkaz: https://doaj.org/article/86118edd787b4c23b6ef49b24624c006

Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation

Autor: Anil Dhawan, Ragai R. Mitry, Celine Filippi, Leanne Glover, Robin D. Hughes, Suttiruk Jitraruch, Sharon C. Lehec

Publikováno v: Cell Transplantation
Cell Transplantation, Vol 26 (2017)
Jitraruch, S, Dhawan, A, Hughes, R D, Filippi, C, Lehec, S C, Glover, L & Mitry, R R 2017, ' Cryopreservation of Hepatocyte Microbeads for Clinical Transplantation ', Cell Transplantation, vol. 26, no. 8, pp. 1341-1354 . https://doi.org/10.1177/0963689717720050

Intraperitoneal transplantation of hepatocyte microbeads is an attractive option for the management of acute liver failure. Encapsulation of hepatocytes in alginate microbeads supports their function and prevents immune attack of the cells. Establish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcb29eaa121eca4a2dff4e4023c836c
http://europepmc.org/articles/PMC5680969

Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure

Autor: David C. Hay, Maesha Deheragoda, Ragai R. Mitry, Valeria Iansante, Sharon C. Lehec, Anil Chandrashekran, Celine Filippi, Emer Fitzpatrick, Tharindu Prema-chandra, Anil Dhawan, C. Starling

Publikováno v: Chandrashekran, A, Mitry, R R, Prema-chandra, T, Starling, C, Lehec, S, Iansante, V, Fitzpatrick, E, Filippi, C, Deheragoda, M, Hay, D & Dhawan, A 2018, ' Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure ', Cell and Gene Therapy Insights, vol. 4, no. 11, pp. 1087-1103 . https://doi.org/10.18609/cgti.2018.111

Much progress has been made in understanding the development of human organs through advanced cellular and molecular techniques. Acute liver failure (ALF) in children is a life-threatening condition that relies on liver or hepatocyte transplantation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca81150672b1cda17675d59c61b5c15
https://www.pure.ed.ac.uk/ws/files/81524061/Chandrasekran.pdf

Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator

Autor: Ragai R. Mitry, Joanne Tang, Siddharth Sinha, Celine Filippi, Charlotte A. Lee, Emer Fitzpatrick, Anil Dhawan, Raquel Fernandez Dacosta, Simon Walker, Valeria Iansante, Maria Koulmanda, Robin D. Hughes

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)

For patients with non-cirrhotic liver-based metabolic disorders, hepatocyte transplantation can be an effective treatment. However, long-term function of transplanted hepatocytes following infusion has not been achieved due to insufficient numbers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7154629909f2a04668dc60aa8819c29
https://pubmed.ncbi.nlm.nih.gov/30820592