Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Celine Dubé"'
Autor:
Shawn McClelland, Gary P Brennan, Celine Dubé, Seeta Rajpara, Shruti Iyer, Cristina Richichi, Christophe Bernard, Tallie Z Baram
Publikováno v:
eLife, Vol 3 (2014)
The mechanisms generating epileptic neuronal networks following insults such as severe seizures are unknown. We have previously shown that interfering with the function of the neuron-restrictive silencer factor (NRSF/REST), an important transcription
Externí odkaz:
https://doaj.org/article/1988140a94ad4323a2aba1f399965d38
Autor:
Natalia Erenburg, Emilio Perucca, Jeff Bechard, Celine Dube, Nina Weishaupt, Robin Sherrington, Meir Bialer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2522 (2024)
The aim of this study was to investigate the comparative antiseizure activity of the l-enantiomers of d,l-fenfluramine and d,l-norfenfluramine and to evaluate the relationship between their concentration in plasma and brain and anticonvulsant activit
Externí odkaz:
https://doaj.org/article/cd237b351e7d4af2890f9817da9d5beb
Autor:
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
Publikováno v:
eLife, Vol 11 (2022)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55
Publikováno v:
Annals of neurology. 53(6)
Excitotoxic cell death is the fundamental process responsible for many human neurodegenerative disorders, yet the basic mechanisms involved are not fully understood. Here, we exploited the fact that the immature brain is remarkably resistant to seizu
Publikováno v:
Hippocampus. 13(3)
Seizures induced by fever (febrile seizures) are the most frequent seizures affecting infants and children; however, their impact on the developing hippocampal formation is not completely understood. Such understanding is highly important because of