Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates

Autor: Celine Boschi, Marion Le Bideau, Julien Andreani, Sarah Aherfi, Priscilla Jardot, Jeremy Delerce, Mathieu Gendrot, Bruno Pradines, Philippe Colson, Anthony Levasseur, Bernard La Scola

Publikováno v: Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1493-1502 (2021)

Background: Despite the fact that the clinical efficacy of hydroxychloroquine is still controversial, it has been demonstrated in vitro to control SARS-CoV-2 multiplication on Vero E6 cells. In this study, we tested the possibility that some patients

Externí odkaz: https://doaj.org/article/2649a8f800664f90b9c8dcb7c1915bb3

Isolation of 4000 SARS-CoV-2 shows that contagiousness is associated with viral load, not vaccine or symptomatic status

Autor: Celine Boschi, Sarah Aherfi, Linda Houhamdi, Philippe Colson, Didier Raoult, Bernard La Scola

Publikováno v: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2276-2278 (2021)

Culture inoculation of 6722 nasopharyngeal samples since February 2020 allowed isolation of 3637 SARS-CoV-2 and confirmed that isolation rate is correlated to viral load, regardless symptomatology or vaccination status. Moreover, the delta variant is

Externí odkaz: https://doaj.org/article/faa32a02829a4eb39ab600aec53b5699

High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2

Autor: Rita Jaafar, Celine Boschi, Sarah Aherfi, Audrey Bancod, Marion Le Bideau, Sophie Edouard, Philippe Colson, Henri Chahinian, Didier Raoult, Nouara Yahi, Jacques Fantini, Bernard La Scola

Publikováno v: Viruses, Vol 13, Iss 11, p 2177 (2021)

Background: Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B

Externí odkaz: https://doaj.org/article/7a542ebc8b8d4521b2b7f6f54d66a65b

SARS-CoV-2 Spike Protein Induces Hemagglutination: Implications for COVID-19 Morbidities and Therapeutics and for Vaccine Adverse Effects

Autor: Celine Boschi, David E. Scheim, Audrey Bancod, Muriel Millitello, Marion Le Bideau, Philippe Colson, Jacques Fantini, Bernard La Scola

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (24), pp.15480. ⟨10.3390/ijms232415480⟩
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15480

Experimental findings for SARS-CoV-2 related to the glycan biochemistry of coronaviruses indicate that attachments from spike protein to glycoconjugates on the surfaces of red blood cells (RBCs), other blood cells and endothelial cells are key to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ec5cfb99667c5448157288dd60e3e2
https://doi.org/10.1101/2022.11.24.517882

High individual heterogeneity of neutralizing activities against the original 4 strain and 9 different variants of SARS-CoV-2

Autor: Rita Jaafar, Celine Boschi, Sarah Aherfi, Audrey Bancod, Marion Le Bideau, Sophie Edouard, Philippe Colson, Henri Chahinian, Didier Raoult, Nouara Yahi, Jacques Fantini, Bernard LA SCOLA

Background. Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by variant of B.1.1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15712226048ca82f3a45e2f190f58f50
https://doi.org/10.21203/rs.3.rs-783298/v2