Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Celina M. D'Cruz"'
Autor:
Alexandra Borodovsky, Travis J. McQuiston, Daniel Stetson, Ambar Ahmed, David Whitston, Jingwen Zhang, Michael Grondine, Deborah Lawson, Sharon S. Challberg, Michael Zinda, Brian A. Pollok, Brian A. Dougherty, Celina M. D’Cruz
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-7 (2017)
Abstract Efforts to develop effective cancer therapeutics have been hindered by a lack of clinically predictive preclinical models which recapitulate this complex disease. Patient derived xenograft (PDX) models have emerged as valuable tools for tran
Externí odkaz:
https://doaj.org/article/35d4fe6ac1204c65ab4eca774df20d90
Autor:
Emma L. Jenkins, Kenji Tamura, Makoto Kodaira, Justin Lindemann, Michael Zinda, Celina M. D'Cruz, Brendon Ladd, Kelly Jacques, Philippa Dudley, Neil James, Vivien Jacobs, Lyndsey Hanson, Claire Crafter, Armelle Logie, Nin Guan, Barry R. Davies
This file contains the supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88b437d053244183f372efec797de0ef
https://doi.org/10.1158/1535-7163.22506828.v1
https://doi.org/10.1158/1535-7163.22506828.v1
Autor:
Emma L. Jenkins, Kenji Tamura, Makoto Kodaira, Justin Lindemann, Michael Zinda, Celina M. D'Cruz, Brendon Ladd, Kelly Jacques, Philippa Dudley, Neil James, Vivien Jacobs, Lyndsey Hanson, Claire Crafter, Armelle Logie, Nin Guan, Barry R. Davies
Supplementary Figure 1: Expression of signalling proteins in MCF10A-AKT1WT and MCF10A-AKT1E17K cells grown in the presence or absence of doxycycline; Supplementary Figure 2: Colony formation in soft agar using MCF10A cells expressing AKT1E17K, AKT1WT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4a86579c7bb9081f8b8e7bccf696df
https://doi.org/10.1158/1535-7163.22506825.v1
https://doi.org/10.1158/1535-7163.22506825.v1
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Pharmacokinetics modelling of AZD2014 intermittent dosing schedule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aab7bc29f3860fec33ee0af943823b0
https://doi.org/10.1158/1535-7163.22505970.v1
https://doi.org/10.1158/1535-7163.22505970.v1
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
HCC1428-eveR and HCC1428-LTED-eveR cell lines resistant to everolimus remain sensitive to dual mTORC1/2 inhibitor AZD2014.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbbecc1501da9a57ed9b2de4b62242f
https://doi.org/10.1158/1535-7163.22505973
https://doi.org/10.1158/1535-7163.22505973
Autor:
Emma L. Jenkins, Kenji Tamura, Makoto Kodaira, Justin Lindemann, Michael Zinda, Celina M. D'Cruz, Brendon Ladd, Kelly Jacques, Philippa Dudley, Neil James, Vivien Jacobs, Lyndsey Hanson, Claire Crafter, Armelle Logie, Nin Guan, Barry R. Davies
AKT1E17K mutations occur at low frequency in a variety of solid tumors, including those of the breast and urinary bladder. Although this mutation has been shown to transform rodent cells in culture, it was found to be less oncogenic than PIK3CA mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0e51073541b5d806d8c14123aee9a3
https://doi.org/10.1158/1535-7163.c.6538500.v1
https://doi.org/10.1158/1535-7163.c.6538500.v1
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Supplementary data on cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b4e1c79aa3f231a187d9a02f72da17
https://doi.org/10.1158/1535-7163.22505964
https://doi.org/10.1158/1535-7163.22505964
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Pharmacokinetics and PK/PD relationships for AZD2014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98473f6fc21ae8f367d8c0594f8ae037
https://doi.org/10.1158/1535-7163.22505979
https://doi.org/10.1158/1535-7163.22505979
Autor:
Sabina C. Cosulich, Stephen Green, Oona Delpuech, Robert McEwen, Urszula M. Polanska, Christine M. Chresta, Martin Pass, Kurt G. Pike, Teresa Klinowska, Graham Bigley, Barry R. Davies, Zoe Howard, Michael Grondine, James W.T. Yates, Celina M. D'Cruz, Teeru Bihani, Jon Curwen, Sylvie M. Guichard
Supplementary table 1: Biochemical and cellular activity of AZD2014. Supplementary table 2: Biochemical activity of AZD2014. Supplementary table 3: Anti proliferative activity of AZD2014 in a panel of ER+, endocrine resistant and LTED cell lines. Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364da65de5509dc97972c00cb9c5f42b
https://doi.org/10.1158/1535-7163.22505976.v1
https://doi.org/10.1158/1535-7163.22505976.v1
Autor:
Celina M. D'Cruz, Edwin A. Clark, Stephen E. Fawell, Corinne Reimer, Michael Zinda, Ammar Adam, Delphine Nicolle, Olivier Déas, Stefano Cairo, Joanne Wilson, Aaron Smith, Maureen Hattersley, David Linsenmayer, Garry Beran, Melanie M. Frigault, Ryan E. Henry, Rhys D.O. Jones, Evan R. Barry, Alwin G. Schuller
Supplemental Methods. Methods used to generate supplemental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5dd7c471b7c4a1ddffa4e34676c5fd
https://doi.org/10.1158/1078-0432.22460742.v1
https://doi.org/10.1158/1078-0432.22460742.v1