Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Celia R Berkers"'
Autor:
Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards
Publikováno v:
eLife, Vol 9 (2020)
The dependency of cancer cells on glutamine may be exploited therapeutically as a new strategy for treating cancers that lack druggable driver genes. Here we found that human liver cancer was dependent on extracellular glutamine. However, targeting g
Externí odkaz:
https://doaj.org/article/67844f9e629f4631a5c877af93e2e1e6
Autor:
Xiangli Jiang, Ali Hyder Baig, Giuliana Palazzo, Rossella Del Pizzo, Toman Bortecen, Sven Groessl, Esther A. Zaal, Cinthia Claudia Amaya Ramirez, Alexander Kowar, Daniela Aviles-Huerta, Celia R. Berkers, Wilhelm Palm, Darjus Tschaharganeh, Jeroen Krijgsveld, Fabricio Loayza-Puch
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), wh
Externí odkaz:
https://doaj.org/article/a98264621b174e53a5059a5de6ea1f66
Autor:
Fenne W. M. Verheijen, Thi N. M. Tran, Jung‐Chin Chang, Femke Broere, Esther A. Zaal, Celia R. Berkers
Publikováno v:
Molecular Oncology, Vol 18, Iss 7, Pp 1759-1776 (2024)
Metabolism plays a crucial role in regulating the function of immune cells in both health and disease, with altered metabolism contributing to the pathogenesis of cancer and many inflammatory diseases. The local microenvironment has a profound impact
Externí odkaz:
https://doaj.org/article/6e98aaaa530640dd8cf3a64c24ef9490
Autor:
Sander de Kivit, Mark Mensink, Sarantos Kostidis, Rico J.E. Derks, Esther A. Zaal, Marieke Heijink, Lotte J. Verleng, Evert de Vries, Ellen Schrama, Niek Blomberg, Celia R. Berkers, Martin Giera, Jannie Borst
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114681- (2024)
Summary: Regulatory T cells (Tregs) suppress pro-inflammatory conventional T cell (Tconv) responses. As lipids impact cell signaling and function, we compare the lipid composition of CD4+ thymus-derived (t)Tregs and Tconvs. Lipidomics reveal constitu
Externí odkaz:
https://doaj.org/article/de51d349abac4044b71dadce296bbfdb
Autor:
Xiaogang Zhang, Patrick F. Greve, Thi Tran Ngoc Minh, Richard Wubbolts, Ayşe Y. Demir, Esther A. Zaal, Celia R. Berkers, Marianne Boes, Willem Stoorvogel
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Seminal plasma induces immune tolerance towards paternal allogenic antigens within the female reproductive tract and during foetal development. Recent evidence suggests a role for extracellular vesicles in seminal plasma (spEVs). We isolated
Externí odkaz:
https://doaj.org/article/4d4b609f02e4428a9d78160e31d76a35
Autor:
Rens Peeters, Jorge Cuenca-Escalona, Esther A. Zaal, Anna T. Hoekstra, Anouk C. G. Balvert, Marcos Vidal-Manrique, Niek Blomberg, Sjoerd J. van Deventer, Rinke Stienstra, Julia Jellusova, Martin Giera, Luciana Hannibal, Ute Spiekerkoetter, Martin ter Beest, Celia R. Berkers, Annemiek B. van Spriel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tetraspanin CD37 deficiency has been reported as a prognostic marker for aggressive B-cell lymphoma. Here, the authors show that CD37 interacts with the fatty acid transporter 1 to inhibit palmitate uptake and its deficiency leads to increased fatty
Externí odkaz:
https://doaj.org/article/06b391ff93194e52ab905cd0ab30f079
Autor:
Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Daniela Annibali, Frédéric Amant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Metabolic reprogramming is associated with cancer development and therapy resistance. Here, the authors show that downregulation of the serine biosynthesis enzyme PHGDH in a fraction of patients is associated with relapse in platinum-treated ovarian
Externí odkaz:
https://doaj.org/article/ea6155ed60d848d191feda4d57429fb3
Autor:
María Matamala Montoya, Gijs J. J. van Slobbe, Jung-Chin Chang, Esther A. Zaal, Celia R. Berkers
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the majority of patients experiencing multiple relapses from different drugs. The MM tumor microen
Externí odkaz:
https://doaj.org/article/ba54417d87c24cbeb40cd7ca6d4cb4e2
Autor:
Pilar González-García, María Elena Díaz-Casado, Agustín Hidalgo-Gutiérrez, Laura Jiménez-Sánchez, Mohammed Bakkali, Eliana Barriocanal-Casado, Germaine Escames, Riccardo Zenezini Chiozzi, Franziska Völlmy, Esther A. Zaal, Celia R. Berkers, Albert J.R. Heck, Luis C. López
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102403- (2022)
Defects in Coenzyme Q (CoQ) metabolism have been associated with primary mitochondrial disorders, neurodegenerative diseases and metabolic conditions. The consequences of CoQ deficiency have not been fully addressed, and effective treatment remains c
Externí odkaz:
https://doaj.org/article/a2808f9af5f749cfa28f555ecb1b8d8d
Autor:
Albert van Dijk, Jennifer Anten, Anne Bakker, Noah Evers, Anna T. Hoekstra, Jung-Chin Chang, Maaike R. Scheenstra, Edwin J. A. Veldhuizen, Mihai G. Netea, Celia R. Berkers, Henk P. Haagsman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection
Externí odkaz:
https://doaj.org/article/d37d6ebc82eb4e7eac6d602f7bf731cf