Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Celia Payen"'
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006339 (2016)
High-throughput sequencing has enabled genetic screens that can rapidly identify mutations that occur during experimental evolution. The presence of a mutation in an evolved lineage does not, however, constitute proof that the mutation is adaptive, g
Externí odkaz:
https://doaj.org/article/e2b0a83de3084ae9bd0933834c27638b
Autor:
Bonita J Brewer, Celia Payen, Sara C Di Rienzi, Megan M Higgins, Giang Ong, Maitreya J Dunham, M K Raghuraman
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005699 (2015)
DNA replication errors are a major driver of evolution--from single nucleotide polymorphisms to large-scale copy number variations (CNVs). Here we test a specific replication-based model to explain the generation of interstitial, inverted triplicatio
Externí odkaz:
https://doaj.org/article/c31b5a7f3f8b49608fa44c43471b7a27
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002155 (2015)
Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell's proliferative ability, or cellular fitness, has remained elusive. In this study, we have combined a detailed analysis of aneuploid clones isolat
Externí odkaz:
https://doaj.org/article/97db6a30f658485f991773357087ab1f
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002016 (2011)
Externí odkaz:
https://doaj.org/article/9ddd6de4a9054b1e8821cdd6257304c3
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000175 (2008)
The propensity of segmental duplications (SDs) to promote genomic instability is of increasing interest since their involvement in numerous human genomic diseases and cancers was revealed. However, the mechanism(s) responsible for their appearance re
Externí odkaz:
https://doaj.org/article/7c250aa4b18e46f0aada660b5525390d
Autor:
Remington E Hoerr, Alex Eng, Celia Payen, Sara C Di Rienzi, M K Raghuraman, Maitreya J Dunham, Bonita J Brewer, Katherine L Friedman
Publikováno v:
GENETICS. 224
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation (CNV). In humans, CNV may be inconsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f18188ce73e54d05eb860a33ba2ae1
https://doi.org/10.1093/genetics/iyad010
https://doi.org/10.1093/genetics/iyad010
Autor:
Remington E. Hoerr, Alex Eng, Celia Payen, Sara C. Di Rienzi, M. K. Raghuraman, Maitreya J. Dunham, Bonita J. Brewer, Katherine L. Friedman
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation. In humans, copy number variation may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f01d7894fa01806a081c5bc2420639c
https://doi.org/10.1101/2022.06.12.495855
https://doi.org/10.1101/2022.06.12.495855
Autor:
Monica R. Sanchez, Adam P. Arkin, Maitreya J. Dunham, Jeffrey M. Skerker, Sarah Bissonnette, Celia Payen, Frances Cheong, Amy A. Caudy, Blake T. Hovde, Rachel B. Brem
Publikováno v:
Genome research, vol 29, iss 3
To understand how complex genetic networks perform and regulate diverse cellular processes, the function of each individual component must be defined. Comprehensive phenotypic studies of mutant alleles have been successful in model organisms in deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe9097379cda541dab184548b6c86c9
https://europepmc.org/articles/PMC6396416/
https://europepmc.org/articles/PMC6396416/
Autor:
Alan F. Rubin, Stanley Fields, Monica R. Sanchez, Matthew S. Rich, Giang T. Ong, Nozomu Yachie, Maitreya J. Dunham, Celia Payen
Publikováno v:
Genetics. 203:191-202
In the yeast Saccharomyces cerevisiae, beneficial mutations selected during sulfate-limited growth are typically amplifications of the SUL1 gene, which encodes the high-affinity sulfate transporter, resulting in fitness increases of >35% . Cis-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccfca1a16c79e9207a124dbb85defbf
https://doi.org/10.1534/genetics.116.188037
https://doi.org/10.1534/genetics.116.188037
With two genomes in the same organism, interspecific hybrids have unique opportunities and costs. In both plants and yeasts, wild, pathogenic, and domesticated hybrids may eliminate portions of one parental genome, a phenomenon known as loss of heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dbf83e2f1e669ab502d20f717b63a0
https://doi.org/10.1101/452748
https://doi.org/10.1101/452748