Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Celia M, Bisbach"'
Autor:
Celia M. Bisbach, Rachel A. Hutto, Deepak Poria, Whitney M. Cleghorn, Fatima Abbas, Frans Vinberg, Vladimir J. Kefalov, James B. Hurley, Susan E. Brockerhoff
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract Rods and cones use intracellular Ca2+ to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca2+ entry into mitochondria in e
Externí odkaz:
https://doaj.org/article/19fb921ccc8343ada232a66140021e5f
Autor:
Celia M. Bisbach, Daniel T. Hass, Brian M. Robbings, Austin M. Rountree, Martin Sadilek, Ian R. Sweet, James B. Hurley
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: When O2 is plentiful, the mitochondrial electron transport chain uses it as a terminal electron acceptor. However, the mammalian retina thrives in a hypoxic niche in the eye. We find that mitochondria in retinas adapt to their hypoxic enviro
Externí odkaz:
https://doaj.org/article/64842dbbc56043f9a737c66ee85c4247
Autor:
Daniel T. Hass, Elizabeth Giering, Celia M. Bisbach, Brian M. Robbings, Thomas O. Mundinger, James B. Hurley
The posterior eye contains two metabolic microenvironments, each occupied by a distinct tissue type. Retinal pigment epithelium (RPE)-choroid tissue is connected to the circulatory system and receives plentiful O2and nutrients. Tight junctions formed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1d6c8d7a6b2f78e754cf821381acabe
https://doi.org/10.1101/2023.04.10.536306
https://doi.org/10.1101/2023.04.10.536306
PurposeSuccinate is exported by the retina and imported by eyecup tissue. The transporter(s) mediating this process have not yet been identified. Recent studies showed that Monocarboxylate Transporter 1 (MCT1) can transport succinate across plasma me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cb7c05cee160fbc42c884c5fcb3e87
https://doi.org/10.1101/2021.11.19.469314
https://doi.org/10.1101/2021.11.19.469314
Autor:
Edward D Parker, Frans Vinberg, William Ge, Whitney M. Cleghorn, James B. Hurley, Rachel Hutto, Susan E. Brockerhoff, Celia M. Bisbach, Benjamin H Bauer, Daniel C Brock, Fatima Abbas
Publikováno v:
Cell Death & Differentiation. 27:1067-1085
Photoreceptors are specialized neurons that rely on Ca2+ to regulate phototransduction and neurotransmission. Photoreceptor dysfunction and degeneration occur when intracellular Ca2+ homeostasis is disrupted. Ca2+ homeostasis is maintained partly by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a12bbbb35d9190fdd1120ab7bec0fd95
https://doi.org/10.1038/s41418-019-0398-2
https://doi.org/10.1038/s41418-019-0398-2
Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss
Autor:
David J. Marcinek, Jeremy Whitson, Mariya T. Sweetwyne, Celia M. Bisbach, Ian R. Sweet, Whitney M. Cleghorn, Ana P. Valencia, Connor Jankowski, Austin M. Rountree, James B. Hurley, Martin Sadilek, Kristine Tsantilas, Brian M. Robbings, Jonathan D. Linton, Peter S. Rabinovitch, Huiliang Zhang, Campbell, Daniel T. Hass
PurposeCharacterize how metabolic function in the murine retina and retinal pigment epithelium-choroid-sclera (eyecup) complex is impacted by natural aging.MethodsWe examined scotopic and photopic visual function of young (3-6 months) and aged (23-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93d0e0ac6ee2a02761df0e803ff6cf39
https://doi.org/10.1101/2021.04.06.438698
https://doi.org/10.1101/2021.04.06.438698
Autor:
James B. Hurley, Daniel T. Hass, Celia M. Bisbach, Ian R. Sweet, Varun Kamat, Martin Sadilek, Brian M. Robbings
Succinate is central in energy metabolism. It is thought to be made and consumed within mitochondria, and not to cross the plasma membrane. Contrary to the canonical role of succinate, it is produced in the retina and released into the extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8df1b0ddb2557905e591794080d4eb13
https://doi.org/10.1101/2021.02.10.430650
https://doi.org/10.1101/2021.02.10.430650
Autor:
Daniel T. Hass, Celia M. Bisbach, Brian M. Robbings, Martin Sadilek, Ian R. Sweet, James B. Hurley
Publikováno v:
Cell Reports. 39:110917
Fumarate can be a surrogate for O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd85810a0151ba490da637e4e1984a31
https://doi.org/10.1016/j.celrep.2022.110917
https://doi.org/10.1016/j.celrep.2022.110917
Publikováno v:
Investigative Opthalmology & Visual Science. 63:1
Succinate is exported by the retina and imported by eyecup tissue. The transporters mediating this process have not yet been identified. Recent studies showed that monocarboxylate transporter 1 (MCT1) can transport succinate across plasma membranes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aeaa3a46a6632c7a67e351ddcfedd8d
https://doi.org/10.1167/iovs.63.4.1
https://doi.org/10.1167/iovs.63.4.1
Autor:
James B. Hurley, Celia M. Bisbach, Frans Vinberg, Fatima Abbas, Deepak Poria, Rachel Hutto, Whitney M. Cleghorn, Susan E. Brockerhoff, Vladimir J. Kefalov
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Scientific Reports
Scientific Reports
Rods and cones use intracellular Ca2+ to regulate many functions, including phototransduction and neurotransmission. The Mitochondrial Calcium Uniporter (MCU) complex is thought to be the primary pathway for Ca2+ entry into mitochondria in eukaryotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783d27c7f5bdefa710824c919a8abcb1
https://doi.org/10.1038/s41598-020-72708-x
https://doi.org/10.1038/s41598-020-72708-x