Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats

Autor: Elena Hernández-Hernández, Sandra Ledesma-Corvi, Fernando Yáñez-Gómez, Celia Garau, Laura Gálvez-Melero, Andrea Bagán, Carmen Escolano, M. Julia García-Fuster

In searching for novel targets to design antidepressants, among the characterized imidazoline receptors (IR), I2 receptors are an innovative therapeutical approach since they are dysregulated in major depressive disorder and by classical antidepressa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6faa6e54902bda8a87c14aaf9e4dce
http://hdl.handle.net/2445/197543

Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed rats

Autor: Celia Garau, Gonzalo P. Urcelay, Jessica Hayes, Giulia Chiacchierini, John Apergis-Schoute, James E. McCutcheon

In anticipation of palatable food, rats can learn to restrict consumption of a less rewarding food type resulting in a binge on the preferred food when it is made available. This construct is known as anticipatory negative contrast (ANC) and can help

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cb53d720fa108b2bf61726c515f75ca
https://doi.org/10.1101/2021.05.20.444943

Ingested non-essential amino acids recruit brain orexin cells to suppress eating in mice

Autor: Paulius Viskaitis, Myrtha Arnold, Celia Garau, Lise T. Jensen, Lars Fugger, Daria Peleg-Raibstein, Denis Burdakov

Publikováno v: Viskaitis, P, Arnold, M, Garau, C, Jensen, L T, Fugger, L, Peleg-Raibstein, D & Burdakov, D 2022, ' Ingested non-essential amino acids recruit brain orexin cells to suppress eating in mice ', Current biology : CB, vol. 32, no. 8, pp. 1812-1821.e4 . https://doi.org/10.1016/j.cub.2022.02.067

Ingested nutrients are proposed to control mammalian behavior by modulating the activity of hypothalamic orexin/hypocretin neurons (HONs). Previous in vitro studies showed that nutrients ubiquitous in mammalian diets, such as non-essential amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a60d63abe9ed32f0ad5049914bc253
https://doi.org/10.1016/j.cub.2022.02.067

Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals

Autor: Celia Garau, Craig Blomeley, Denis Burdakov

Publikováno v: Nature Neuroscience. 21:29-32

Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472ab6553a3a7f2d65002b919de133fc
https://doi.org/10.1038/s41593-017-0023-y

Neuropeptide S precursor knockout mice display memory and arousal deficits

Autor: Hans-Christian Pape, Rainer K. Reinscheid, Celia Garau, Kay Jüngling, Wei Si, Stefan Schulz, Xiaobin Liu

Publikováno v: The European journal of neuroscience. 46(1)

Activation of neuropeptide S (NPS) signaling has been found to produce arousal, wakefulness, anxiolytic-like behaviors, and enhanced memory formation. In order to further study physiological functions of the NPS system, we generated NPS precursor kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f571604395bb693500f3dad3413aa
https://pubmed.ncbi.nlm.nih.gov/28548278