Výsledky vyhledávání - "Celia F. Brosnan"

Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion

Autor: Sarah E. Lutz, Venkatesh Jeganathan, Nicholas E.S. Sibinga, Prameladevi Chinnasamy, Dario F. Riascos-Bernal, Celia F. Brosnan, Isabel Casimiro

Publikováno v: Molecular Medicine. 21:233-241

Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS), is mediated by myelin-specific autoreactive T cells that cause inflammation and demyelination in the central nervous system (CNS), with significant con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851061fd6585b7e098ec349a96e2095c
https://doi.org/10.2119/molmed.2014.00264

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The astrocyte in multiple sclerosis revisited

Autor: Celia F. Brosnan, Cedric S. Raine

Publikováno v: Glia. 61:453-465

Among the constituent cell types of the multiple sclerosis (MS) plaque, the astrocyte has been the least considered as a player in the pathogenesis of the lesion. Traditionally, it has been assigned a secondary scarring role with little or no role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298f25449d7f25352ba142d1ad9c148c
https://doi.org/10.1002/glia.22443

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Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice

Autor: Sarah E. Lutz, Cedric S. Raine, Celia F. Brosnan

Publikováno v: Journal of Neuroimmunology. 245:8-14

We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination. In this study we tested the hypothesis that loss of astrocytic gap junction proteins leads to exacerbation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d13275780645b62d98f46b2386c68e5
https://doi.org/10.1016/j.jneuroim.2012.01.007

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TLR3 and TLR4 are innate antiviral immune receptors in human microglia: Role of IRF3 in modulating antiviral and inflammatory response in the CNS

Autor: Sunhee C. Lee, Hyeon-Sook Suh, Meng-Liang Zhao, Namjong Choi, Thomas J. Belbin, Celia F. Brosnan

Publikováno v: Virology. 392:246-259

In the CNS, microglia are the primary targets of HIV infection. In this study, we investigated the effect of activation of the innate antiviral receptors TLR3 and TLR4 on HIV infection of primary human microglia, as well as microglial cell signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedbcd6a753d9b85f0be0b17cf021ab6
https://doi.org/10.1016/j.virol.2009.07.001

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Deletion of Astrocyte Connexins 43 and 30 Leads to a Dysmyelinating Phenotype and Hippocampal CA1 Vacuolation

Autor: Yongmei Zhao, Sunhee C. Lee, Maria Gulinello, Cedric S. Raine, Celia F. Brosnan, Sarah E. Lutz

Publikováno v: Journal of Neuroscience. 29:7743-7752

Astrocytes are coupled via gap junctions (GJs) comprising connexin 43 (Cx43) (Gja1) and Cx30 (Gjb6), which facilitate intercellular exchange of ions. Astrocyte connexins also form heterotypic GJs with oligodendrocytic somata and lamellae. Loss of oli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9070b0b55db846c35367ebc030ad978f
https://doi.org/10.1523/jneurosci.0341-09.2009

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EAE Tolerance Induction with Hsp70-Peptide Complexes Depends on H60 and NKG2D Activity

Autor: Cedric S. Raine, Celia F. Brosnan, Krzysztof Selmaj, Anna Jurewicz, Wojciech Orlowski, Grazyna Galazka, Mariusz Stasiołek

Publikováno v: The Journal of Immunology. 179:4503-4512

Inflammation leads to induction of tissue stress conditions that might contribute to the generation of mechanisms limiting ongoing immune responses. We have shown previously that peptides derived from brain tissue of mice with experimental autoimmune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6332c40dd3c3312f1e9992102064f4
https://doi.org/10.4049/jimmunol.179.7.4503

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The TLR3 ligand polyI:C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF-κB and PI3 kinase pathways

Autor: Eliana Scemes, Yongmei Zhao, Sarah E. Lutz, Celia F. Brosnan, Mark A. Rivieccio

Publikováno v: Glia. 54:775-785

Toll-like receptor 3 (TLR3) is a component of the innate immune response that responds to dsRNA viruses and virus replication intermediates. In this study we show that activation of astrocytes with the dsRNA mimetic polyinosinic-cytidylic acid (pI:C)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a592dd301d7d3d1bd9c965474138284f
https://doi.org/10.1002/glia.20418

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Interleukin-11 Potentiates Oligodendrocyte Survival and Maturation, and Myelin Formation

Autor: Gareth R. John, Cedric S. Raine, Carla Taveggia, Yueting Zhang, Steven Einheber, James L. Salzer, Celia F. Brosnan, Carmen V. Melendez-Vasquez

Publikováno v: The Journal of Neuroscience. 26:12174-12185

Mechanisms that regulate oligodendrocyte survival and myelin formation are an intense focus of research into myelin repair in the lesions of multiple sclerosis (MS). Although demyelination and oligodendrocyte loss are pathological hallmarks of the di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d1d54697784a67e836673b61ff0bf4
https://doi.org/10.1523/jneurosci.2289-06.2006

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