Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions

Autor: Anastasia Tsaalbi-Shtylik, Rossana Aprigliano, Niels de Wind, Daniela C.F. Salvatori, Matthias Bosshard, Marc H.G.P. Raaijmakers, Ronald van Os, Celia Dingemanse-van der Spek, Albertina Dethmers-Ausema, Barbara van Loon, Gerald de Haan, Keiji Hashimoto, Masaaki Moriya, Si Chen, Nima Borhan Fakouri, Seka Lazare, Lene Juel Rasmussen, Ana Martín-Pardillos

Publikováno v: Blood, 130(13), 1523-1534. AMER SOC HEMATOLOGY
Blood, 130(13), 1523-1534
Blood, 130(13), 1523-1534. American Society of Hematology

Endogenous DNA damage is causally associated with the functional decline and transformation of stem cells that characterize aging. DNA lesions that have escaped DNA repair can induce replication stress and genomic breaks that induce senescence and ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303237965cefbec89cd518ec17b7d33
https://research.rug.nl/en/publications/aa9f02d3-22fc-43b4-8020-b72d57383feb

UV exposure inhibits intestinal tumor growth and progression to malignancy in intestine-specific Apc mutant mice kept on low vitamin D diet

Autor: Heggert, Rebel, Celia Dingemanse-van, der Spek, Daniela, Salvatori, Johannes P T M, van Leeuwen, Els C, Robanus-Maandag, Frank R, de Gruijl

Publikováno v: International journal of cancer. 136(2)

Mortality from colorectal cancer increases with latitude and decreases with ambient UV radiation. We investigated whether moderate UV dosages could inhibit intestinal tumor development and whether this corresponded with UV-induced vitamin D. FabplCre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0a9ffc95c58c80a55a34faff20841e3
https://pubmed.ncbi.nlm.nih.gov/24890436