Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Celia D'Arienzo"'
Autor:
Lorell N. Discenza, Aaron Balog, Christine Huang, Robin Moore, Asoka Ranasinghe, Tai-An Lin, Celia D'Arienzo, Timothy V. Olah
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1207
BMS-986205 (Linrodostat) is a small molecule inhibitor of Indoleamine 2, 3 dioxygenase (IDO) that is currently being evaluated in clinical trials for the oral treatment of advanced cancer. Initially, there were concerns regarding possible toxicity fo
Autor:
Lisa M. Kopcho, Johnni Gullo-Brown, Shweta Padmanabhan, Pattasseri Shabeerali, Arvind Mathur, Prabhakar Rajanna, Lorell Discenza, Liping Zhang, Zhenqiu Hong, Sarah C. Traeger, Zheng Yang, Cherney Emily Charlotte, Richard Rampulla, David K. Williams, Gopal Dhar, Kimberly A. Foster, James Kempson, Derrick Maley, Mary F. Grubb, Xiao Zhu, Xin Li, Weifang Shan, Robert M. Borzilleri, Diane Delpy, Kevin Stefanski, T. Thanga Mariappan, Gregory D. Vite, Kathy A. Johnston, Audris Huang, Asoka Ranasinghe, Mark Fereshteh, Aravind Anandam, Steven P. Seitz, John T. Hunt, Aaron Balog, Celia D’Arienzo, Anuradha Gupta, Tai-An Lin, Roshan Y. Nimje, Weiwei Guo, Christine Huang, Venkata Murali, Sandeep Mahankali
Publikováno v:
ACS Med Chem Lett
[Image: see text] IDO1 inhibitors have shown promise as immunotherapies for the treatment of a variety of cancers, including metastatic melanoma and renal cell carcinoma. We recently reported the identification of several novel heme-displacing IDO1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f0d7f8a891846e7ad07844b139d549
https://europepmc.org/articles/PMC8274105/
https://europepmc.org/articles/PMC8274105/
Autor:
Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
Publikováno v:
Journal of Medicinal Chemistry. 62:8953-8972
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based
Autor:
Charu Chaudhry, Percy H. Carter, Moslin Ryan M, Celia D’Arienzo, James Lin, Jodi K. Muckelbauer, Luisa Salter-Cid, Tracy L. Taylor, Kim W. McIntyre, Chunjian Liu, James R. Burke, Paul A. Elzinga, Hyunsoo Park, Kathleen M. Gillooly, Chiehying Chang, Dianlin Xie, Jing Chen, Lihong Cheng, David S. Weinstein, Cliff Chen, Jeffrey Tredup, Huadong Sun, Peng Li, Louis J. Lombardo, Adriana Zupa-Fernandez, Joann Strnad, John S. Tokarski, Dauh-Rurng Wu, Nelly Aranibar
Publikováno v:
ACS Medicinal Chemistry Letters. 10:383-388
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically improved metabolic sta
Autor:
Lloyd Lecureux, Elizabeth M. Heimrich, Rochelle Thomas, Lois D. Lehman-McKeeman, Hai-Yun Xiao, Georgia Cornelius, Zheng Yang, Alaric J. Dyckman, Anuradha Gupta, Percy H. Carter, Yu-Wen Li, Paul Levesque, Tracy L. Taylor, Zili Xiao, Mary Ellen Cvijic, Arvind Mathur, John L. Gilmore, Lei Gong, Jenny Xie, Marta Dabros, Ding Ren Shen, Xiaoxia Yang, T. G. Murali Dhar, Xia D. Zhou, Yang Michael G, Bala Pragalathan, Huadong Sun, Anthony M. Marino, Hong Shi, Dauh-Rurng Wu, Richard Rampulla, Kim W. McIntyre, Cliff Chen, Luisa Salter-Cid, Bethanne M. Warrack, Celia D’Arienzo, Virna Borowski
Publikováno v:
Journal of Medicinal Chemistry. 62:2265-2285
Recently, our research group reported the identification of BMS-986104 (2) as a differentiated S1P1 receptor modulator. In comparison to fingolimod (1), a full agonist of S1P1 currently marketed for the treatment of relapse remitting multiple scleros
Autor:
Celia D’Arienzo, Paul Ponath, Serhiy Hnatyshyn, Eugene Ciccimaro, Timothy V Olah, Asoka Ranasinghe
Publikováno v:
Rapid Communications in Mass Spectrometry. 35
Rationale Gangliosides (GS) are attractive targets in biomarker discovery because of their physiological significance in numerous human diseases including certain cancers and developmental and metabolic disorders. The robust strategy described here e
Autor:
Lorell Discenza, Aaron J. Balog, Christine Huang, Robin Moore, Asoka Ranasinghe, Tai-An Lin, Celia D’Arienzo, Timothy V. Olah
Publikováno v:
SSRN Electronic Journal.
Autor:
Steven P. Seitz, Gregory D. Vite, John T. Hunt, Mark Fereshteh, Cherney Emily Charlotte, Joseph Fargnoli, Lorell Discenza, Liping Zhang, Jennifer Brown, Xin Li, Kevin Stefanski, Christine Huang, Asoka Ranasinghe, Lisa M. Kopcho, Xiao Zhu, Aaron Balog, Diane Delpy, Sarah C. Traeger, Jesse Swanson, Mary F. Grubb, Zheng Yang, Theresa Ziemba, Kathy A. Johnston, Kimberly A. Foster, Johnni Gullo-Brown, Celia D’Arienzo, Susheel Jethanand Nara, Robert M. Borzilleri, Derrick Maley, Tai-An Lin
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing dioxygenase enzyme implicated in cancer immune response. This account details the discovery of BMS-986242, a novel IDO1 inhibitor designed for the treatment of a variety of c
Autor:
Soo S. Ko, James Kempson, Yingru Zhang, Tracy L. Taylor, Kim W. McIntyre, James R. Burke, Luisa Salter-Cid, Shiuhang Yip, Celia D’Arienzo, Aberra Fura, Stacey Skala, Joseph A. Tino, Jun Dai, Chunlei Wang, Joel C. Barrish, Michael Galella, Kathleen M. Gillooly, Bei Wang, Dauh-Rurng Wu, Lorell Discenza, Xiaoping Hou, Arvind Mathur, Richard Rampulla, Dawn Sun, Scott H. Watterson, Mary T. Obermeier, Percy H. Carter, Mark A. Pattoli, Anurag S. Srivastava, Lihong Cheng, Rulin Zhao, Peng Li, Claudine Pulicicchio, Joseph Pawluczyk, Rodney Vickery
Publikováno v:
ACS Med Chem Lett
[Image: see text] Bruton’s tyrosine kinase (BTK) has been shown to play a key role in the pathogenesis of autoimmunity. Therefore, the inhibition of the kinase activity of BTK with a small molecule inhibitor could offer a breakthrough in the clinic