Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Celia Alda-Catalinas"'
Autor:
Celia Alda-Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Bin Sun, William Pembroke, Sebastian Ullrich, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A
Externí odkaz:
https://doaj.org/article/c304ef90e9444591bb08261355ae7dd1
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100426- (2021)
Summary: CRISPR/Cas9 screens are a powerful approach to identify key regulators of biological processes. By combining pooled CRISPR/Cas9 screening with single-cell RNA-sequencing readout, individual perturbations can be assessed in parallel both comp
Externí odkaz:
https://doaj.org/article/dca591d608bb423db8c449b62ca6d5cf
Autor:
Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for paralle
Externí odkaz:
https://doaj.org/article/ee5160af085446eb92ec31544e77c471
Autor:
Celia Alda Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Drug targets with human genetic evidence are expected to increase clinical success by at least two-fold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of early drug discovery. A key iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18edd229f5eeebe62906e7c14bea9b
https://doi.org/10.1101/2023.05.14.540711
https://doi.org/10.1101/2023.05.14.540711
Autor:
Wolf Reik, Mélanie A. Eckersley-Maslin, Elisa Kreibich, Marloes Blotenburg, Celia Alda-Catalinas, Christel Krueger
Publikováno v:
Genes & Development. 33:194-208
The molecular regulation of zygotic genome activation (ZGA) in mammals remains an exciting area of research. Primed mouse embryonic stem cells contain a rare subset of “2C-like” cells that are epigenetically and transcriptionally similar to the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263e7c2e1122c05673e995a4d3be5c97
https://doi.org/10.1101/gad.321174.118
https://doi.org/10.1101/gad.321174.118
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 2, Pp 100426-(2021)
STAR Protocols, Vol 2, Iss 2, Pp 100426-(2021)
Summary CRISPR/Cas9 screens are a powerful approach to identify key regulators of biological processes. By combining pooled CRISPR/Cas9 screening with single-cell RNA-sequencing readout, individual perturbations can be assessed in parallel both compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf988c3a9350febf23c4cc2a6ab006be
https://doi.org/10.1016/j.xpro.2021.100426
https://doi.org/10.1016/j.xpro.2021.100426
Autor:
Wolf Reik, Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, Fátima Santos, Mélanie A. Eckersley-Maslin, Oana Kubinyecz, Oliver Stegle
Zygotic genome activation (ZGA) is a crucial developmental milestone that remains poorly understood. This first essential transcriptional event in embryonic development coincides with extensive epigenetic reprogramming processes and is orchestrated,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737c50dcc792b18ae8b16f06505c4168
https://doi.org/10.1101/741371
https://doi.org/10.1101/741371
Autor:
Fátima Santos, Oana Kubinyecz, Mélanie A. Eckersley-Maslin, Celia Alda-Catalinas, Wolf Reik, Irene Hernando-Herraez, Danila Bredikhin, Oliver Stegle
Publikováno v:
Cell Systems
Summary Zygotic genome activation (ZGA) is an essential transcriptional event in embryonic development that coincides with extensive epigenetic reprogramming. Complex manipulation techniques and maternal stores of proteins preclude large-scale functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3000ff9941ce38233ad5fcc3f0fe93cd
https://pubmed.ncbi.nlm.nih.gov/32634384
https://pubmed.ncbi.nlm.nih.gov/32634384
Autor:
Mélanie A. Eckersley-Maslin, Marloes Blotenburg, Elisa Kreibich, Celia Alda-Catalinas, Wolf Reik, Christel Krueger
The molecular regulation of zygotic genome activation (ZGA) in mammals remains poorly understood. Primed mouse embryonic stem cells contain a rare subset of “2C-like” cells that are epigenetically and transcriptionally similar to the two cell emb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5ac642a1b0612f3545cce4861c9875
https://doi.org/10.1101/431890
https://doi.org/10.1101/431890
Publikováno v:
Nature reviews. Molecular cell biology. 19(7)
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling, genome spatial reorganization and substantial transcriptional cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6558274852467a81090dc278e149cc
https://pubmed.ncbi.nlm.nih.gov/29686419
https://pubmed.ncbi.nlm.nih.gov/29686419