Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Celia A Schiffer"'
Autor:
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selectiv
Externí odkaz:
https://doaj.org/article/c3903556c3ab42faabeedc9cf418281c
Publikováno v:
Viruses, Vol 16, Iss 9, p 1419 (2024)
Enterovirus-D68 (EV68) has emerged as a global health concern over the last decade with severe symptomatic infections resulting in long-lasting neurological deficits and death. Unfortunately, there are currently no FDA-approved antiviral drugs for EV
Externí odkaz:
https://doaj.org/article/b304b3b4b5dd451dbbc5d39452e58a8a
Autor:
Atanu Maiti, Adam K. Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan K. Watts, Celia A. Schiffer, Hiroshi Matsuo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Here, the enzymatic activity of APOBEC3G resulting in conversion of 2′-deoxy-zebularine into a hydration product allowed the authors to capture the transition state, which provides a blueprint for designing a new class of transition state-mimicking
Externí odkaz:
https://doaj.org/article/9b59b40269cb4ef4b61dc593fa6d83f7
Publikováno v:
Journal of cellular biochemistry [J Cell Biochem] 2016 Mar; Vol. 117 (3), pp. 806.
Autor:
Ala M. Shaqra, Sarah N. Zvornicanin, Qiu Yu J. Huang, Gordon J. Lockbaum, Mark Knapp, Laura Tandeske, David T. Bakan, Julia Flynn, Daniel N. A. Bolon, Stephanie Moquin, Dustin Dovala, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors determined crystal structures of the main protease (Mpro) of SARS-CoV-2 bound to substrate peptides. These structures define the substrate envelope and enable identification of sites that may be susceptible to drug resistance.
Externí odkaz:
https://doaj.org/article/9bf0515b0c364d1eb5c19629a361ea7c
Autor:
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Publikováno v:
eLife, Vol 12 (2023)
Darunavir (DRV) is exceptional among potent HIV-1 protease inhibitors (PIs) in high drug concentrations that are achieved in vivo. Little is known about the de novo resistance pathway for DRV. We selected for resistance to high drug concentrations ag
Externí odkaz:
https://doaj.org/article/63dc44fcc5244ba9ab0bca60d287bf74
Autor:
Qi Li, Fiachra Humphries, Roxie C. Girardin, Aaron Wallace, Monir Ejemel, Alla Amcheslavsky, Conor T. McMahon, Zachary A. Schiller, Zepei Ma, John Cruz, Alan P. Dupuis, Anne F. Payne, Arooma Maryam, Nese Kurt Yilmaz, Kathleen A. McDonough, Brian G. Pierce, Celia A. Schiffer, Andrew C. Kruse, Mark S. Klempner, Lisa A. Cavacini, Katherine A. Fitzgerald, Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Anti-COVID antibody therapeutics have been developed but not widely used due to their high cost and escape of neutralization from the emerging variants. Here, we describe the development of VHH-IgA1.1, a nanobody IgA fusion molecule as an inhalable,
Externí odkaz:
https://doaj.org/article/daf01ec763884ddfa115d5def03c2186
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Autor:
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Publikováno v:
eLife, Vol 11 (2022)
With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. The SARS-Co
Externí odkaz:
https://doaj.org/article/1d6d9ed5a9a3431a897dfc2f4cfe6b4b
Autor:
Sarah N. Zvornicanin, Ala M. Shaqra, Qiuyu J. Huang, Elizabeth Ornelas, Mallika Moghe, Mark Knapp, Stephanie Moquin, Dustin Dovala, Celia A. Schiffer, Nese Kurt Yilmaz
Publikováno v:
Viruses, Vol 15, Iss 3, p 781 (2023)
With the spread of SARS-CoV-2 throughout the globe causing the COVID-19 pandemic, the threat of zoonotic transmissions of coronaviruses (CoV) has become even more evident. As human infections have been caused by alpha- and beta-CoVs, structural chara
Externí odkaz:
https://doaj.org/article/9ffbfdbf549b423f93c1b2a6fa8578c1
Autor:
Wayne D. Harshbarger, Derrick Deming, Gordon J. Lockbaum, Nattapol Attatippaholkun, Maliwan Kamkaew, Shurong Hou, Mohan Somasundaran, Jennifer P. Wang, Robert W. Finberg, Quan Karen Zhu, Celia A. Schiffer, Wayne A. Marasco
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Previously, a broadly neutralizing antibody, 3I14, active against groups 1 and 2 influenza A viruses was isolated from human memory B cells and showed protection in mice from lethal viral challenge. Here, Harshbarger and Deming et al. provide the cry
Externí odkaz:
https://doaj.org/article/246479680d0d43448f6a2d4b305f320c