Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Celeste Owen"'
Autor:
Andrew Wang, Luciene R. Carraro-Lacroix, Celeste Owen, Bowen Gao, Paul N. Corey, Pascal Tyrrell, John H. Brumell, Irina Voronov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mT
Externí odkaz:
https://doaj.org/article/48c316c68a3b41edb20300c3142b91c4
Autor:
Bret A. Moore, Brian C. Leonard, Lionel Sebbag, Sydney G. Edwards, Ann Cooper, Denise M. Imai, Ewan Straiton, Luis Santos, Christopher Reilly, Stephen M. Griffey, Lynette Bower, David Clary, Jeremy Mason, Michel J. Roux, Hamid Meziane, Yann Herault, International Mouse Phenotyping Consortium, Colin McKerlie, Ann M. Flenniken, Lauryl M. J. Nutter, Zorana Berberovic, Celeste Owen, Susan Newbigging, Hibret Adissu, Mohammed Eskandarian, Chih-Wei Hsu, Sowmya Kalaga, Uchechukwu Udensi, Chinwe Asomugha, Ritu Bohat, Juan J. Gallegos, John R. Seavitt, Jason D. Heaney, Arthur L. Beaudet, Mary E. Dickinson, Monica J. Justice, Vivek Philip, Vivek Kumar, Karen L. Svenson, Robert E. Braun, Sara Wells, Heather Cater, Michelle Stewart, Sharon Clementson-Mobbs, Russell Joynson, Xiang Gao, Tomohiro Suzuki, Shigeharu Wakana, Damian Smedley, J. K. Seong, Glauco Tocchini-Valentini, Mark Moore, Colin Fletcher, Natasha Karp, Ramiro Ramirez-Solis, Jacqueline K. White, Martin Hrabe de Angelis, Wolfgang Wurst, Sara M. Thomasy, Paul Flicek, Helen Parkinson, Steve D. M. Brown, Terrence F. Meehan, Patsy M. Nishina, Stephen A. Murray, Mark P. Krebs, Ann-Marie Mallon, K. C. Kent Lloyd, Christopher J. Murphy, Ala Moshiri
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-2 (2019)
In the original published version of the article, Valerie Vancollie was mistakenly omitted from the list of members of the International Mouse Phenotyping Consortium. In addition, recognition of funding from Wellcome Trust grant WT098051 was mistaken
Externí odkaz:
https://doaj.org/article/8d8550fc215047fe947e147fb5638498
Autor:
Irina Voronov, Bowen Gao, Paul Corey, John H. Brumell, Luciene R. Carraro-Lacroix, Pascal N. Tyrrell, Andrew Wang, Celeste Owen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mTORC1 is l
Autor:
Elena Bajenova, Andrew Wang, John H. Brumell, Yingwei Hu, Celeste Owen, Irina Voronov, Paul Corey, Luciene R. Carraro-Lacroix
Publikováno v:
Journal of Cellular Biochemistry. 117:413-425
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in the regulation of cell growth. It has been shown to play an important role in osteoclast differentiation, particularly at the earlier stages of osteoclastogenesis. mTOR act
Autor:
Irina Voronov, Danielle E Johnson, Lisa Johnson, Bernhard Ganss, Ralph A Zirngibl, Grace Bradley, Andrew Wang, Celeste Owen
Publikováno v:
Journal of cellular biochemistry. 118(10)
Vacuolar H+ -ATPases (V-ATPases) are ubiquitous multisubunit proton pumps responsible for organellar pH maintenance. Mutations in the a3 subunit of V-ATPases cause autosomal recessive osteopetrosis, a rare disease due to impaired bone resorption. Pat
Publikováno v:
Journal of Cellular Biochemistry. 114:2823-2833
Vacuolar-type H(+)-ATPases (V-ATPases) are located in lysosomes and at the ruffled border in osteoclasts. We showed previously that the R740S mutation is dominant negative for V-ATPase activity, uncouples proton transport from ATP hydrolysis and caus
Autor:
Morris F. Manolson, Celeste Owen, Irina Voronov, Jane E. Aubin, Noelle Ochotny, Valentin Jaumouillé
Publikováno v:
Journal of Bone and Mineral Research. 28:108-118
Vacuolar H+-ATPase (V-ATPase), a multisubunit enzyme located at the ruffled border and in lysosomes of osteoclasts, is necessary for bone resorption. We previously showed that heterozygous mice with an R740S mutation in the a3 subunit of V-ATPase (+/
Autor:
Marc D. Grynpas, Tayyab S Khan, William L. Stanford, Christina Holmes, Nadia Ciliberti, Celeste Owen
Publikováno v:
Journal of Bone and Mineral Research. 22:1373-1386
We performed a longitudinal analysis of bone quality in Sca-1-null mice. A tight temporal, site-specific association between Sca-1-deficient BMD deficiency and reduced mesenchymal progenitor fre- quency was observed. Defects in trabecular microarchit
Publikováno v:
Journal of cellular biochemistry. 114(12)
Vacuolar-type H(+)-ATPases (V-ATPases) are located in lysosomes and at the ruffled border in osteoclasts. We showed previously that the R740S mutation is dominant negative for V-ATPase activity, uncouples proton transport from ATP hydrolysis and caus
Autor:
Ann M. Flenniken, Jane E. Aubin, Lucy R. Osborne, Frieda Chen, S. Lee Adamson, Janet Rossant, Shoji Ichikawa, Celeste Owen
Publikováno v:
Journal of cellular biochemistry. 113(7)
X-linked hypophosphatemic rickets (XLH) is a dominantly inherited disease characterized by renal phosphate wasting, aberrant vitamin D metabolism, and defective bone mineralization. It is known that XLH in humans and in certain mouse models is caused