Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Celeste B. Greer"'
Autor:
Justin R. Haynes, Clayton A. Whitmore, William J. Behof, Charlotte A. Landman, Henry H. Ong, Andrew P. Feld, Isabelle C. Suero, Celeste B. Greer, John C. Gore, Printha Wijesinghe, Joanne A. Matsubara, Brian E. Wadzinski, Benjamin W. Spiller, Wellington Pham
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The classical amyloid cascade hypothesis postulates that the aggregation of amyloid plaques and the accumulation of intracellular hyperphosphorylated Tau tangles, together, lead to profound neuronal death. However, emerging research has demo
Externí odkaz:
https://doaj.org/article/c762f9905491477abe67360110002bce
Autor:
Wesley L. Cai, Celeste B. Greer, Jocelyn F. Chen, Anna Arnal-Estapé, Jian Cao, Qin Yan, Don X. Nguyen
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Background Few somatic mutations have been linked to breast cancer metastasis, whereas transcriptomic differences among primary tumors correlate with incidence of metastasis, especially to the lungs and brain. However, the epigenomic alterat
Externí odkaz:
https://doaj.org/article/ab87df052f1042da9558ebcc14ccc2e6
Autor:
Shane G. Poplawski, Krassimira A. Garbett, Rebekah L. McMahan, Holly B. Kordasiewicz, Hien Zhao, Andrew J. Kennedy, Slavina B. Goleva, Teresa H. Sanders, S. Timothy Motley, Eric E. Swayze, David J. Ecker, J. David Sweatt, Todd P. Michael, Celeste B. Greer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1399-1412 (2020)
Knockout of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 have potential as therapeutics for disorders affecting memory. Currently available HDAC2 catalytic activity inhibit
Externí odkaz:
https://doaj.org/article/663dff1bf29f4ebeac30337a05a1aae1
Autor:
Lili Liao, Nilda L. Alicea‐Velázquez, Lauren Langbein, Xiaohua Niu, Weijia Cai, Eun‐Ah Cho, Meiling Zhang, Celeste B. Greer, Qin Yan, Michael S. Cosgrove, Haifeng Yang
Publikováno v:
Molecular Oncology, Vol 13, Iss 4, Pp 811-828 (2019)
Polybromo‐1 (PBRM1) is an important tumor suppressor in kidney cancer. It contains six tandem bromodomains (BDs), which are specialized structures that recognize acetyl‐lysine residues. While BD2 has been found to bind acetylated histone H3 lysin
Externí odkaz:
https://doaj.org/article/c57fd6c15dc2484c9410ea2022415536
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Epigenetic modifications such as histone methylation permit change in chromatin structure without accompanying change in the underlying genomic sequence. A number of studies in animal models have shown that dysregulation of various component
Externí odkaz:
https://doaj.org/article/faaad56028474fe78efd312e7914a343
Autor:
Celeste B. Greer, Yoshiaki Tanaka, Yoon Jung Kim, Peng Xie, Michael Q. Zhang, In-Hyun Park, Tae Hoon Kim
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1444-1455 (2015)
Transcription elongation regulates the expression of many genes, including oncogenes. Histone deacetylase (HDAC) inhibitors (HDACIs) block elongation, suggesting that HDACs are involved in gene activation. To understand this, we analyzed nascent tran
Externí odkaz:
https://doaj.org/article/b79d09e8eecf4214ba87d69b410beabd
Autor:
S.P. Moran, A.Y. Jin, J. Wright, Garrett A. Kaas, Andrew J. Kennedy, K.S. Chronister, J.D. Sweatt, Celeste B. Greer, R.M. Lazerenko, J.D. Weiss, Junda Zhu
Publikováno v:
The Journal of Neuroscience
The dynamic regulation of DNA methylation in postmitotic neurons is necessary for memory formation and other adaptive behaviors. Ten-eleven translocation 1 (TET1) plays a part in these processes by oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylc
Autor:
Meaghan Hall, Mark A. Brimble, Andrew M. Davidoff, Brandon J. Walters, Iva B. Zovkic, Timothy A.B. McLean, Celeste B. Greer, Anas Reda, Amanda M. Leonetti, Patrick J. Murphy, Jacqueline M. Zakaria, Jennet Baumbach, Samantha D. Creighton, Gilda Stefanelli, Claire E. Makowski
Publikováno v:
Cell reports
SUMMARY Rapid removal of histone H2A.Z from neuronal chromatin is a key step in learning-induced gene expression and memory formation, but mechanisms underlying learning-induced H2A.Z removal are unclear. Anp32e was recently identified as an H2A.Z-sp
Autor:
Anna Arnal-Estapé, Don X. Nguyen, Qin Yan, Jocelyn F. Chen, Wesley L. Cai, Jian Cao, Celeste B. Greer
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-18 (2020)
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-18 (2020)
Background Few somatic mutations have been linked to breast cancer metastasis, whereas transcriptomic differences among primary tumors correlate with incidence of metastasis, especially to the lungs and brain. However, the epigenomic alterations and
Autor:
Hien T Zhao, S. Timothy Motley, Teresa H. Sanders, Celeste B. Greer, J. David Sweatt, Krassimira A. Garbett, Shane G. Poplawski, Andrew J. Kennedy, Rebekah L. McMahan, Holly B. Kordasiewicz, Slavina B. Goleva, David J. Ecker, Todd P. Michael, Eric E. Swayze
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 19, Iss, Pp 1399-1412 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Knockout of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 have potential as therapeutics for disorders affecting memory. Currently available HDAC2 catalytic activity inhibit