Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Celedon Gonzales"'
Autor:
Jennifer Witcher, Linda M. Rorick-Kehn, Conrad J. Wong, Gemma L. Dickinson, Celedon Gonzales, Randall Stoltz, Robert Bell, Stephen L. Lowe, Sitra Tauscher-Wisniewski, MaryAnn Weller, Jane Royalty
Publikováno v:
The Journal of Clinical Pharmacology. 54:968-978
Accumulating evidence indicates that selective antagonism of kappa opioid receptors may provide therapeutic benefit in the treatment of major depressive disorder, anxiety disorders, and substance use disorders. LY2456302 is a high-affinity, selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9ca0c913986733965edb67a81dab579
https://doi.org/10.1002/jcph.286
https://doi.org/10.1002/jcph.286
Autor:
John A. Tzaferis, Zeshan Ahmed, Ying Yt. Yang, Jirong Lu, Ronald B. DeMattos, John R. Sims, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Celedon Gonzales, Feng Liu, Michael C. Irizarry, Philip Iversent, Michael Hutton, Patrick C. May, Christer Nordstedt, Wesley H. Anderson, Alice Fisher, Justin T. Hole, Herold Oluoch, Leonard N. Boggs, Margaret M. Racke
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cabaa7afeb5f2ff39a1d02150b35b1ca
https://doi.org/10.1016/j.jalz.2016.07.146
https://doi.org/10.1016/j.jalz.2016.07.146
Autor:
Robert J. Konrad, Brian A. Willis, Adam J. Schwarz, Ronald B. DeMattos, Sergey Shcherbinin, Anne Hawdon, Michael C. Irizarry, John R. Sims, Masako Nakano, Mark A. Mintun, Robert A. Dean, Michael D. Devous, Shino Fujimoto, Celedon Gonzales, Stephen L. Lowe, Peng Liu
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e9ab3a636ce6353f854f4a014178d3
https://doi.org/10.1016/j.jalz.2016.06.665
https://doi.org/10.1016/j.jalz.2016.06.665
Autor:
Martin R. Farlow, Ronald B. DeMattos, Robert A. Dean, Steven M. Paul, Christopher H. van Dyck, Stuart Friedrich, Gopalan Sethuraman, Paul S. Aisen, Steven E. Arnold, Eric Siemers, Richard C. Mohs, B. Joy Snider, Celedon Gonzales, Anton P. Porsteinsson
Publikováno v:
Alzheimer's & Dementia. 8:261-271
Objectives To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of 12 weekly infusions of solanezumab, an anti-β-amyloid (Aβ) antibody, in patients with mild-to-moderate Alzheimer's disease. Cognitive measures were also obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a1e3cc862fab716088ab69821d7b4f
https://doi.org/10.1016/j.jalz.2011.09.224
https://doi.org/10.1016/j.jalz.2011.09.224
Autor:
Jill Chappell, Celedon Gonzales, Larry Ereshefsky, Lu Zhang, Philip T Leese, David Hoelscher, Malcolm I. Mitchell, J. T. Callaghan, Mark Leibowitz, M. Derby
Publikováno v:
Journal of Cardiovascular Pharmacology. 49:384-393
The effects of supratherapeutic dosages of duloxetine, a serotonin and norepinephrine reuptake inhibitor, on blood pressure and pulse rate were assessed in a multicenter, double-blind, randomized, placebo-controlled, crossover study in 117 healthy wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4d5797b8d5a84bb5283b50c492b204
https://doi.org/10.1097/fjc.0b013e31804d1cce
https://doi.org/10.1097/fjc.0b013e31804d1cce
Autor:
Philip T Leese, Mary Pat Knadler, Jennie Lin Francis, David Hoelscher, Lu Zhang, J. T. Callaghan, Larry Ereshefsky, David S. Small, Durisala Desaiah, Celedon Gonzales, Jill Chappell, M. Derby, Mark Leibowitz
Publikováno v:
Journal of Cardiovascular Pharmacology. 49:146-153
The electrophysiological effects of duloxetine at supratherapeutic exposures were evaluated to ensure compliance with regulatory criteria and to assess the QT prolongation potential.Electrocardiograms were collected in a multicenter, double-blind, ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e8266cf35a63eff0bc8cfa87bbcff5
https://doi.org/10.1097/fjc.0b013e318030aff7
https://doi.org/10.1097/fjc.0b013e318030aff7
Autor:
Philip Iversent, Jirong Lu, Theresa A. Day, Wesley H. Anderson, Margaret M. Racke, Alice Fisher, Zhixiang Yang, John A. Tzaferis, Dustin J. Mergott, Scott A. Monk, Leonard N. Boggs, Michael C. Irizarry, Patrick C. May, Zeshan Ahmed, Feng Liu, John R. Sims, Justin T. Hole, Michael Hutton, Ying Y.T. Yang, Ronald B. DeMattos, Christer Nordstedt, Celedon Gonzales
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af55a735cd66417c6c43c5638258b69
https://doi.org/10.1016/j.jalz.2015.07.364
https://doi.org/10.1016/j.jalz.2015.07.364
Autor:
Conrad J. Wong, Linda M. Rorick-Kehn, Jeffrey G. Suico, John Hart, Robert Bell, Jennifer Witcher, Michael A. Statnick, Charles H. Mitch, Celedon Gonzales, Anne B. Need, David L. McKinzie, Jamie H. McKinzie, Mary Ann Weller, Stephen L. Lowe, Randall R. Stoltz, Sitra Tauscher-Wisniewski
Publikováno v:
International Journal of Neuropsychopharmacology
Background: Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression. The kappa opioid receptor antagonist, LY2456302, exhibits ~30-fold higher affinity for kappa opioid receptors over mu opioid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701ee8bc7e48965fd37f4aa8612cd2d1
https://doi.org/10.1093/ijnp/pyu036
https://doi.org/10.1093/ijnp/pyu036
Autor:
Brian Michael Mathes, Zhixiang Yang, Dustin J. Mergott, Scott A. Monk, Hykop Gevorkyan, Larry Ereshefsky, Vaught Grant Matthews, Leonard L. Winneroski, Jon A. Erickson, Stephen L. Lowe, Celedon Gonzales, Scott Martin Sheehan, David E. Timm, Brian Morgan Watson, Ferenc Martenyi, David O. Calligaro, Stephanie L. Stout, Theresa A. Day, Richard A. Brier, Patrick J Cocke, Brian A. Willis, Stanford Jhee, Leonard N. Boggs, Robert A. Dean, James E. Audia, Steven F. Komjathy, Anthony R. Borders, Terry D. Lindstrom, Patrick C. May, Douglas E. James, Linglin Li
BACE1 is a key protease controlling the formation of amyloid β, a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD). Therefore, the development of potent and selective inhibitors of BACE1 has been a focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c69adc5fae76e66024d7197aeccfc
https://europepmc.org/articles/PMC6605527/
https://europepmc.org/articles/PMC6605527/
Autor:
Robert A. Dean, Eric Siemers, Martin R. Farlow, Michael H. Skinner, Patrick J. C. May, Daniel K. Ness, Celedon Gonzales, Julie Satterwhite
Publikováno v:
Clinical Neuropharmacology. 28:126-132
Amyloid beta (Abeta) may play a central role in the pathogenesis of Alzheimer disease. A functional gamma-secretase inhibitor, LY450139, was developed that inhibits Abeta formation in whole cell assays, transgenic mice, and beagle dogs. The authors w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b1fa635f614e79820af34bd1ab6585
https://doi.org/10.1097/01.wnf.0000167360.27670.29
https://doi.org/10.1097/01.wnf.0000167360.27670.29